ID   SDHD_PSEAE              Reviewed;         448 AA.
AC   Q9HYN9;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Probable D-serine dehydratase {ECO:0000255|HAMAP-Rule:MF_01030};
DE            EC=4.3.1.18 {ECO:0000255|HAMAP-Rule:MF_01030};
DE   AltName: Full=D-serine deaminase {ECO:0000255|HAMAP-Rule:MF_01030};
DE            Short=DSD {ECO:0000255|HAMAP-Rule:MF_01030};
GN   Name=dsdA {ECO:0000255|HAMAP-Rule:MF_01030}; OrderedLocusNames=PA3357;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC   -!- SIMILARITY: Belongs to the serine/threonine dehydratase family. DsdA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01030}.
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DR   EMBL; AE004091; AAG06745.1; -; Genomic_DNA.
DR   PIR; D83225; D83225.
DR   RefSeq; NP_252047.1; NC_002516.2.
DR   RefSeq; WP_003113132.1; NZ_QZGE01000017.1.
DR   AlphaFoldDB; Q9HYN9; -.
DR   SMR; Q9HYN9; -.
DR   STRING; 287.DR97_4570; -.
DR   PaxDb; Q9HYN9; -.
DR   PRIDE; Q9HYN9; -.
DR   DNASU; 882524; -.
DR   EnsemblBacteria; AAG06745; AAG06745; PA3357.
DR   GeneID; 882524; -.
DR   KEGG; pae:PA3357; -.
DR   PATRIC; fig|208964.12.peg.3516; -.
DR   PseudoCAP; PA3357; -.
DR   HOGENOM; CLU_035707_0_0_6; -.
DR   InParanoid; Q9HYN9; -.
DR   OMA; ESDPNCF; -.
DR   PhylomeDB; Q9HYN9; -.
DR   BioCyc; PAER208964:G1FZ6-3421-MON; -.
DR   BRENDA; 4.3.1.18; 5087.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0008721; F:D-serine ammonia-lyase activity; IDA:PseudoCAP.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0036088; P:D-serine catabolic process; IBA:GO_Central.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   HAMAP; MF_01030; D_Ser_dehydrat; 1.
DR   InterPro; IPR011780; D_Ser_am_lyase.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   PANTHER; PTHR48078:SF9; PTHR48078:SF9; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR02035; D_Ser_am_lyase; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   3: Inferred from homology;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..448
FT                   /note="Probable D-serine dehydratase"
FT                   /id="PRO_0000185618"
FT   MOD_RES         119
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01030"
SQ   SEQUENCE   448 AA;  48219 MW;  CA32EFE786EDEB48 CRC64;
     MILGTPKADW LAEFPRLADL IALRPSEWFN PAIAPSAEAL ADVGLGAADV ADASARLQRF
     APLIARLFPE TAASGGIIES DLVEVATFHD ALRQHYAAEL PGRLWLKRDS HLPISGSIKA
     RGGIYEVLAH AERLALEHGL VGLDDDYSRL AEADCRAFFA RHRIAVGSTG NLGLSIGIIG
     AALGFQASVH MSADARQWKK DKLRAHGVTV VEYASDYSVA VEQGRREAAG DPYTHFVDDE
     NSRDLFLGYA VAAERLRGQL DAAGIRVDSE HPLFVHLPCG VGGGPGGVAF GLKLAFGDAV
     HCLFAEPTHS PCMFLGVYTG RHEQVSVQDF GIDNRTAADG LAVGRPSGFV GRAMQRLLDG
     YYTVDDDELF RLLALLERSQ GIRLEPSALA GATGIARVTR EPQGYRERMG LTSARLANAT
     HLVWATGGGM VPETEMRAYL ERGRSLLD