BEX5_HUMAN
ID BEX5_HUMAN Reviewed; 111 AA.
AC Q5H9J7; Q569J0; Q56A74;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein BEX5;
DE AltName: Full=Brain-expressed X-linked protein 5;
DE AltName: Full=NGFRAP1-like protein 1;
DE AltName: Full=Nerve growth factor receptor-associated protein 2;
GN Name=BEX5; Synonyms=NADE2, NGFRAP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEGRADATION BY THE
RP PROTEASOME.
RX PubMed=15958283; DOI=10.1016/j.gene.2005.05.012;
RA Alvarez E., Zhou W., Witta S.E., Freed C.R.;
RT "Characterization of the Bex gene family in humans, mice, and rats.";
RL Gene 357:18-28(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5H9J7; Q13515: BFSP2; NbExp=3; IntAct=EBI-10243741, EBI-10229433;
CC Q5H9J7; Q9H9Q2: COPS7B; NbExp=3; IntAct=EBI-10243741, EBI-2510162;
CC Q5H9J7; G5E9A7: DMWD; NbExp=3; IntAct=EBI-10243741, EBI-10976677;
CC Q5H9J7; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-10243741, EBI-21603100;
CC Q5H9J7; Q9Y6C2: EMILIN1; NbExp=4; IntAct=EBI-10243741, EBI-744586;
CC Q5H9J7; O95363: FARS2; NbExp=3; IntAct=EBI-10243741, EBI-2513774;
CC Q5H9J7; P22607: FGFR3; NbExp=3; IntAct=EBI-10243741, EBI-348399;
CC Q5H9J7; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-10243741, EBI-10226858;
CC Q5H9J7; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-10243741, EBI-11961494;
CC Q5H9J7; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-10243741, EBI-11427343;
CC Q5H9J7; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-10243741, EBI-10181260;
CC Q5H9J7; P06396: GSN; NbExp=3; IntAct=EBI-10243741, EBI-351506;
CC Q5H9J7; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-10243741, EBI-1054873;
CC Q5H9J7; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-10243741, EBI-10263367;
CC Q5H9J7; O15116: LSM1; NbExp=3; IntAct=EBI-10243741, EBI-347619;
CC Q5H9J7; P43361: MAGEA8; NbExp=7; IntAct=EBI-10243741, EBI-10182930;
CC Q5H9J7; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-10243741, EBI-10288852;
CC Q5H9J7; Q15014: MORF4L2; NbExp=3; IntAct=EBI-10243741, EBI-399257;
CC Q5H9J7; O14561: NDUFAB1; NbExp=3; IntAct=EBI-10243741, EBI-1246261;
CC Q5H9J7; P35240-4: NF2; NbExp=3; IntAct=EBI-10243741, EBI-1014514;
CC Q5H9J7; Q8N7B6-2: PACRGL; NbExp=3; IntAct=EBI-10243741, EBI-10694433;
CC Q5H9J7; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10243741, EBI-5235340;
CC Q5H9J7; Q13148: TARDBP; NbExp=6; IntAct=EBI-10243741, EBI-372899;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15958283}.
CC -!- PTM: Ubiquitinated (Probable). Degraded by the proteasome.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: The mouse orthologous protein seems not to exist. Koo et
CC al (PubMed:15861462) have described a sequence that they named Bex5,
CC but it probably represents a pseudogene.
CC -!- SIMILARITY: Belongs to the BEX family. {ECO:0000305}.
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DR EMBL; AY833564; AAX40682.1; -; mRNA.
DR EMBL; Z70719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042818; AAH42818.1; -; mRNA.
DR EMBL; BC092450; AAH92450.1; -; mRNA.
DR EMBL; BC106955; AAI06956.1; -; mRNA.
DR CCDS; CCDS35350.1; -.
DR RefSeq; NP_001012996.1; NM_001012978.2.
DR RefSeq; NP_001153032.1; NM_001159560.1.
DR AlphaFoldDB; Q5H9J7; -.
DR SMR; Q5H9J7; -.
DR BioGRID; 131069; 28.
DR IntAct; Q5H9J7; 25.
DR STRING; 9606.ENSP00000446054; -.
DR iPTMnet; Q5H9J7; -.
DR PhosphoSitePlus; Q5H9J7; -.
DR BioMuta; BEX5; -.
DR DMDM; 74755456; -.
DR MassIVE; Q5H9J7; -.
DR PaxDb; Q5H9J7; -.
DR PeptideAtlas; Q5H9J7; -.
DR PRIDE; Q5H9J7; -.
DR ProteomicsDB; 62890; -.
DR Antibodypedia; 28852; 37 antibodies from 9 providers.
DR DNASU; 340542; -.
DR Ensembl; ENST00000333643.4; ENSP00000328030.3; ENSG00000184515.11.
DR Ensembl; ENST00000543160.5; ENSP00000446054.1; ENSG00000184515.11.
DR GeneID; 340542; -.
DR KEGG; hsa:340542; -.
DR MANE-Select; ENST00000333643.4; ENSP00000328030.3; NM_001012978.3; NP_001012996.1.
DR UCSC; uc004eir.4; human.
DR CTD; 340542; -.
DR DisGeNET; 340542; -.
DR GeneCards; BEX5; -.
DR HGNC; HGNC:27990; BEX5.
DR HPA; ENSG00000184515; Tissue enhanced (brain, pituitary gland).
DR MIM; 300693; gene.
DR neXtProt; NX_Q5H9J7; -.
DR OpenTargets; ENSG00000184515; -.
DR PharmGKB; PA162377554; -.
DR VEuPathDB; HostDB:ENSG00000184515; -.
DR eggNOG; ENOG502R12Q; Eukaryota.
DR GeneTree; ENSGT00940000153412; -.
DR HOGENOM; CLU_123122_0_0_1; -.
DR InParanoid; Q5H9J7; -.
DR OMA; NEEAHPL; -.
DR OrthoDB; 1577493at2759; -.
DR PhylomeDB; Q5H9J7; -.
DR TreeFam; TF337909; -.
DR PathwayCommons; Q5H9J7; -.
DR SignaLink; Q5H9J7; -.
DR BioGRID-ORCS; 340542; 12 hits in 696 CRISPR screens.
DR ChiTaRS; BEX5; human.
DR GenomeRNAi; 340542; -.
DR Pharos; Q5H9J7; Tdark.
DR PRO; PR:Q5H9J7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5H9J7; protein.
DR Bgee; ENSG00000184515; Expressed in endothelial cell and 162 other tissues.
DR Genevisible; Q5H9J7; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR007623; BEX.
DR InterPro; IPR021156; TF_A-like/BEX.
DR PANTHER; PTHR19430; PTHR19430; 1.
DR Pfam; PF04538; BEX; 1.
DR PIRSF; PIRSF008633; BEX; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Ubl conjugation.
FT CHAIN 1..111
FT /note="Protein BEX5"
FT /id="PRO_0000229788"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 27
FT /note="E -> G (in Ref. 3; AAH92450)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="P -> H (in Ref. 3; AAH42818)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 12602 MW; 1FCB30E1BAA20725 CRC64;
MENVPKENKV VEKAPVQNEA PALGGGEYQE PGGNVKGVWA PPAPGFGEDV PNRLVDNIDM
IDGDGDDMER FMEEMRELRR KIRELQLRYS LRILIGDPPH HDHHDEFCLM P
