SDHD_SALTY
ID SDHD_SALTY Reviewed; 440 AA.
AC Q8ZL08;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=D-serine dehydratase {ECO:0000255|HAMAP-Rule:MF_01030};
DE EC=4.3.1.18 {ECO:0000255|HAMAP-Rule:MF_01030};
DE AltName: Full=D-serine deaminase {ECO:0000255|HAMAP-Rule:MF_01030};
DE Short=DSD {ECO:0000255|HAMAP-Rule:MF_01030};
GN Name=dsdA {ECO:0000255|HAMAP-Rule:MF_01030}; OrderedLocusNames=STM3802;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_01030}.
CC -!- SIMILARITY: Belongs to the serine/threonine dehydratase family. DsdA
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01030}.
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DR EMBL; AE006468; AAL22662.1; -; Genomic_DNA.
DR RefSeq; NP_462703.1; NC_003197.2.
DR RefSeq; WP_000427997.1; NC_003197.2.
DR PDB; 3R0X; X-ray; 1.93 A; A=1-440.
DR PDB; 3R0Z; X-ray; 2.40 A; A=1-440.
DR PDB; 6AA9; X-ray; 2.70 A; A=1-440.
DR PDBsum; 3R0X; -.
DR PDBsum; 3R0Z; -.
DR PDBsum; 6AA9; -.
DR AlphaFoldDB; Q8ZL08; -.
DR SMR; Q8ZL08; -.
DR STRING; 99287.STM3802; -.
DR PaxDb; Q8ZL08; -.
DR EnsemblBacteria; AAL22662; AAL22662; STM3802.
DR GeneID; 1255329; -.
DR KEGG; stm:STM3802; -.
DR PATRIC; fig|99287.12.peg.4023; -.
DR HOGENOM; CLU_035707_0_0_6; -.
DR OMA; ESDPNCF; -.
DR PhylomeDB; Q8ZL08; -.
DR BioCyc; SENT99287:STM3802-MON; -.
DR BRENDA; 4.3.1.18; 5542.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0008721; F:D-serine ammonia-lyase activity; IBA:GO_Central.
DR GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0036088; P:D-serine catabolic process; IBA:GO_Central.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1100; -; 2.
DR HAMAP; MF_01030; D_Ser_dehydrat; 1.
DR InterPro; IPR011780; D_Ser_am_lyase.
DR InterPro; IPR001926; PLP-dep.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR PANTHER; PTHR48078:SF9; PTHR48078:SF9; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; SSF53686; 1.
DR TIGRFAMs; TIGR02035; D_Ser_am_lyase; 1.
DR PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Lyase; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..440
FT /note="D-serine dehydratase"
FT /id="PRO_0000185620"
FT MOD_RES 116
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01030"
FT HELIX 2..8
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 13..18
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 33..36
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 44..56
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 58..64
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 66..71
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 83..93
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 99..105
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 110..112
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 115..134
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 144..148
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 150..156
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 160..164
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 168..180
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 183..189
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 194..201
FT /evidence="ECO:0007829|PDB:3R0X"
FT TURN 202..204
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 206..212
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 214..226
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 231..234
FT /evidence="ECO:0007829|PDB:3R0X"
FT TURN 236..238
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 240..247
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 249..260
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 265..268
FT /evidence="ECO:0007829|PDB:3R0Z"
FT STRAND 270..275
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 277..279
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 280..293
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 294..296
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 297..304
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 309..316
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 319..321
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 325..327
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 336..338
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 346..351
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 352..354
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 356..361
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 363..377
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 383..390
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 391..397
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 399..404
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 409..412
FT /evidence="ECO:0007829|PDB:3R0X"
FT STRAND 416..421
FT /evidence="ECO:0007829|PDB:3R0X"
FT HELIX 429..437
FT /evidence="ECO:0007829|PDB:3R0X"
SQ SEQUENCE 440 AA; 47369 MW; 488BB3561968D7C5 CRC64;
MENIQKLIAR YPLVEDLVAL KETTWFNPGA TSLAQGLPYV GLTEQDVNAA HDRLARFAPY
LAKAFPQTAA AGGMIESDVV AIPAMQKRLE KEYGQTINGE MLLKKDSHLA ISGSIKARGG
IYEVLTHAEK LALEAGLLTT DDDYSVLLSP EFKQFFSQYS IAVGSTGNLG LSIGIMSACI
GFKVTVHMSA DARAWKKAKL RSHGVTVVEY EDDYGVAVEQ GRKAAQSDPN CFFIDDENSR
TLFLGYAVAG QRLKAQFAQQ GRVVDASHPL FVYLPCGVGG GPGGVAFGLK LAFGDNVHCF
FAEPTHSPCM LLGVYTGLHD AISVQDIGID NLTAADGLAV GRASGFVGRA MERLLDGLYT
LDDQTMYDML GWLAQEEGIR LEPSALAGMA GPQRICASVA YQQRHGFSQT QLGNATHLVW
ATGGGMVPED EMEQYLAKGR
