ID   BEXA_HAEIF              Reviewed;         217 AA.
AC   P10640;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=ATP-binding protein BexA;
GN   Name=bexA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Eagan / Serotype B;
RX   PubMed=3284653; DOI=10.1016/0092-8674(88)90155-9;
RA   Kroll J.S., Hopkins I., Moxon E.R.;
RT   "Capsule loss in H. influenzae type b occurs by recombination-mediated
RT   disruption of a gene essential for polysaccharide export.";
RL   Cell 53:347-356(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Eagan / Serotype B;
RX   PubMed=2082145; DOI=10.1111/j.1365-2958.1990.tb02034.x;
RA   Kroll J.S., Loynds B., Brophy L.N., Moxon E.R.;
RT   "The bex locus in encapsulated Haemophilus influenzae: a chromosomal region
RT   involved in capsule polysaccharide export.";
RL   Mol. Microbiol. 4:1853-1862(1990).
CC   -!- FUNCTION: Putative ATP-binding protein, and an energy-coupling
CC       component of capsule polysaccharide export apparatus.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; M19995; AAA24944.1; -; Genomic_DNA.
DR   EMBL; X54987; CAA38734.1; -; Genomic_DNA.
DR   PIR; S12235; BVHIXA.
DR   RefSeq; WP_015702020.1; NZ_UEXC01000034.1.
DR   AlphaFoldDB; P10640; -.
DR   SMR; P10640; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   CDD; cd03220; ABC_KpsT_Wzt; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015860; ABC_transpr_TagH-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Capsule biogenesis/degradation; Cell inner membrane;
KW   Cell membrane; Membrane; Nucleotide-binding; Polysaccharide transport;
KW   Sugar transport; Transport.
FT   CHAIN           1..217
FT                   /note="ATP-binding protein BexA"
FT                   /id="PRO_0000091947"
FT   DOMAIN          2..217
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   217 AA;  24746 MW;  96EDB78F1EED79BE CRC64;
     MIRVNNVCKK YHTNSGWKTV LKNINFELQK GEKIGILGRN GAGKSTLIRL MSGVEPPTSG
     TIERSMSISW PLAFSGAFQG SLTGMDNLRF ICRLYDVDPD YVTRFTKEFS ELGDYLYEPV
     KKYSSGMKAR LAFALSLSVE FDCYLIDEVI AVGDSRFAEK CKYELFEKRK DRSIILVSHS
     PSAMKSYCDN AVVLENGIMH HFEDMDKAYQ YYNETQK