SDHD_STAS1
ID SDHD_STAS1 Reviewed; 433 AA.
AC Q4A041;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable D-serine dehydratase {ECO:0000255|HAMAP-Rule:MF_01030};
DE EC=4.3.1.18 {ECO:0000255|HAMAP-Rule:MF_01030};
DE AltName: Full=D-serine deaminase {ECO:0000255|HAMAP-Rule:MF_01030};
DE Short=DSD {ECO:0000255|HAMAP-Rule:MF_01030};
GN Name=dsdA {ECO:0000255|HAMAP-Rule:MF_01030}; OrderedLocusNames=SSP0432;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:13977,
CC ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:35247; EC=4.3.1.18;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01030};
CC -!- SIMILARITY: Belongs to the serine/threonine dehydratase family. DsdA
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01030}.
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DR EMBL; AP008934; BAE17577.1; -; Genomic_DNA.
DR RefSeq; WP_011302399.1; NZ_MTGA01000036.1.
DR AlphaFoldDB; Q4A041; -.
DR SMR; Q4A041; -.
DR STRING; 342451.SSP0432; -.
DR EnsemblBacteria; BAE17577; BAE17577; SSP0432.
DR KEGG; ssp:SSP0432; -.
DR PATRIC; fig|342451.11.peg.437; -.
DR eggNOG; COG3048; Bacteria.
DR HOGENOM; CLU_035707_0_0_9; -.
DR OMA; ESDPNCF; -.
DR OrthoDB; 912282at2; -.
DR BRENDA; 4.3.1.18; 5880.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0008721; F:D-serine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0046416; P:D-amino acid metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1100; -; 2.
DR HAMAP; MF_01030; D_Ser_dehydrat; 1.
DR InterPro; IPR011780; D_Ser_am_lyase.
DR InterPro; IPR001926; PLP-dep.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR PANTHER; PTHR48078:SF9; PTHR48078:SF9; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; SSF53686; 1.
DR TIGRFAMs; TIGR02035; D_Ser_am_lyase; 1.
DR PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE 3: Inferred from homology;
KW Lyase; Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..433
FT /note="Probable D-serine dehydratase"
FT /id="PRO_0000291745"
FT MOD_RES 112
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01030"
SQ SEQUENCE 433 AA; 48000 MW; FFE3D605DD45A407 CRC64;
MNDLATLKQD FPLIDSMQNY KPIFWENPNF RKPASLTFTL KDMEDAAQRL ERFSSYISTV
FPETENNHGL IESPLKHIPF MQNTLTNIES LPIEGKLWLK CDSHLAISGS IKARGGIYEV
LKLAETIAMQ DGDLKETADY RVLAEQKYQD LFSKYNVAVG STGNLGLSIG IMSAKLGFKV
TVHMSTDARQ WKKDLLRSRG VEVIEHQSDY QYAVAEGRKH AENDPTCHFV DDEGSSDLFL
GYTVAALRLK AQLAAENIQI DAEHPLFVYI PCGVGGGPGG VTFGLKQVFG EHVYCIFTEP
THAPCMLLGM MTQLHDKISV KDIGIDGNTD ADGLAVARPS RLVGQIMNTL LYGIQTVSDS
EMYRYLYLLS EKEDIFIEPS AASGFAGIKS AITLAKQQGI QMNQANHIVW ATGGNMVPKE
EMLKYVNHGK SCL