ABDB_DROME
ID ABDB_DROME Reviewed; 493 AA.
AC P09087; Q9VEQ8; Q9VEQ9;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 3.
DT 03-AUG-2022, entry version 209.
DE RecName: Full=Homeobox protein abdominal-B;
DE AltName: Full=Infraabdominal 7;
DE Short=IAB-7;
DE AltName: Full=P3;
DE AltName: Full=PH189;
GN Name=Abd-B; ORFNames=CG10291;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS M AND R).
RC STRAIN=Canton-S;
RX PubMed=7667301; DOI=10.1073/pnas.92.18.8398;
RA Martin C.H., Mayeda C.A., Davis C.A., Ericsson C.L., Knafels J.D.,
RA Mathog D.R., Celniker S.E., Lewis E.B., Palazzolo M.J.;
RT "Complete sequence of the bithorax complex of Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:8398-8402(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM R), AND CHARACTERIZATION.
RC TISSUE=Embryo;
RX PubMed=2903049; DOI=10.1002/j.1460-2075.1988.tb03189.x;
RA Delorenzi M., Ali N., Saari G., Henry C., Wilcox M., Bienz M.;
RT "Evidence that the Abdominal-B r element function is conferred by a trans-
RT regulatory homeoprotein.";
RL EMBO J. 7:3223-3231(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M), AND CHARACTERIZATION.
RC TISSUE=Embryo, and Pupae;
RX PubMed=2575066; DOI=10.1101/gad.3.9.1424;
RA Celniker S.E., Keelan D.J., Lewis E.B.;
RT "The molecular genetics of the bithorax complex of Drosophila:
RT characterization of the products of the Abdominal-B domain.";
RL Genes Dev. 3:1424-1436(1989).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM M).
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=2482824; DOI=10.1101/gad.3.12a.1969;
RA Zavortink M., Sakonju S.;
RT "The morphogenetic and regulatory functions of the Drosophila Abdominal-B
RT gene are encoded in overlapping RNAs transcribed from separate promoters.";
RL Genes Dev. 3:1969-1981(1989).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS M AND R).
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 387-447.
RX PubMed=2416463; DOI=10.1016/0092-8674(85)90013-3;
RA Regulski M., Harding K., Kostriken R., Karch F., Levine M., McGinnis W.;
RT "Homeo box genes of the Antennapedia and bithorax complexes of
RT Drosophila.";
RL Cell 43:71-80(1985).
RN [8]
RP ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=2903050; DOI=10.1002/j.1460-2075.1988.tb03190.x;
RA Kuziora M.A., McGinnis W.;
RT "Different transcripts of the Drosophila Abd-B gene correlate with distinct
RT genetic sub-functions.";
RL EMBO J. 7:3233-3244(1988).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=M; Synonyms=Morphogenetic, Abd-BI;
CC IsoId=P09087-1; Sequence=Displayed;
CC Name=R; Synonyms=Regulatory, Abd-BII;
CC IsoId=P09087-2; Sequence=VSP_002396;
CC -!- TISSUE SPECIFICITY: Isoform M and isoform R are expressed in ectodermal
CC and mesodermal tissues and central nervous system of fourth to ninth
CC embryonic abdominal segments. Later in embryogenesis, expression is
CC seen in visceral mesoderm surrounding hindgut and in two Malpighian
CC tubules. {ECO:0000269|PubMed:2903050}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed during embryogenesis, lower
CC expression in larvae, pupae and adults. {ECO:0000269|PubMed:2903050}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; U31961; AAA84402.1; -; Genomic_DNA.
DR EMBL; U31961; AAA84403.1; -; Genomic_DNA.
DR EMBL; M21173; AAA28400.1; -; mRNA.
DR EMBL; X16134; CAA34260.1; -; mRNA.
DR EMBL; X51663; CAB57859.1; -; mRNA.
DR EMBL; AE014297; AAF55362.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55363.1; -; Genomic_DNA.
DR EMBL; X15080; CAA33187.1; -; mRNA.
DR PIR; A32584; A32584.
DR PIR; A34220; A34220.
DR PIR; B24780; B24780.
DR RefSeq; NP_001303471.1; NM_001316542.1. [P09087-2]
DR RefSeq; NP_001303472.1; NM_001316543.1. [P09087-1]
DR RefSeq; NP_001303474.1; NM_001316545.1. [P09087-2]
DR RefSeq; NP_524896.2; NM_080157.3. [P09087-1]
DR RefSeq; NP_650577.1; NM_142320.2. [P09087-2]
DR RefSeq; NP_732180.1; NM_169735.2. [P09087-2]
DR RefSeq; NP_732181.1; NM_169736.2. [P09087-2]
DR RefSeq; NP_996220.1; NM_206498.2. [P09087-2]
DR PDB; 5ZJQ; X-ray; 2.44 A; A=369-452.
DR PDB; 5ZJR; X-ray; 3.03 A; A=369-452.
DR PDB; 5ZJS; X-ray; 2.90 A; A=369-452.
DR PDB; 5ZJT; X-ray; 2.40 A; A/E=369-452.
DR PDBsum; 5ZJQ; -.
DR PDBsum; 5ZJR; -.
DR PDBsum; 5ZJS; -.
DR PDBsum; 5ZJT; -.
DR AlphaFoldDB; P09087; -.
DR SMR; P09087; -.
DR BioGRID; 70921; 61.
DR DIP; DIP-19566N; -.
DR IntAct; P09087; 3.
DR STRING; 7227.FBpp0082826; -.
DR PaxDb; P09087; -.
DR DNASU; 47763; -.
DR EnsemblMetazoa; FBtr0083381; FBpp0082823; FBgn0000015. [P09087-2]
DR EnsemblMetazoa; FBtr0083382; FBpp0082824; FBgn0000015. [P09087-2]
DR EnsemblMetazoa; FBtr0083383; FBpp0082825; FBgn0000015. [P09087-2]
DR EnsemblMetazoa; FBtr0083384; FBpp0082826; FBgn0000015. [P09087-1]
DR EnsemblMetazoa; FBtr0083385; FBpp0089276; FBgn0000015. [P09087-2]
DR EnsemblMetazoa; FBtr0415463; FBpp0373669; FBgn0000015. [P09087-1]
DR EnsemblMetazoa; FBtr0415464; FBpp0373670; FBgn0000015. [P09087-2]
DR EnsemblMetazoa; FBtr0415465; FBpp0373671; FBgn0000015. [P09087-2]
DR GeneID; 47763; -.
DR KEGG; dme:Dmel_CG11648; -.
DR CTD; 47763; -.
DR FlyBase; FBgn0000015; Abd-B.
DR VEuPathDB; VectorBase:FBgn0000015; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000168206; -.
DR HOGENOM; CLU_545455_0_0_1; -.
DR InParanoid; P09087; -.
DR OMA; APWPYND; -.
DR PhylomeDB; P09087; -.
DR SignaLink; P09087; -.
DR BioGRID-ORCS; 47763; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 47763; -.
DR PRO; PR:P09087; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000015; Expressed in oviduct (Drosophila) and 41 other tissues.
DR ExpressionAtlas; P09087; baseline and differential.
DR Genevisible; P09087; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005704; C:polytene chromosome band; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:FlyBase.
DR GO; GO:0035225; P:determination of genital disc primordium; IMP:FlyBase.
DR GO; GO:0035261; P:external genitalia morphogenesis; IMP:FlyBase.
DR GO; GO:0030540; P:female genitalia development; IMP:FlyBase.
DR GO; GO:0035224; P:genital disc anterior/posterior pattern formation; IEP:FlyBase.
DR GO; GO:0035263; P:genital disc sexually dimorphic development; IMP:FlyBase.
DR GO; GO:0008354; P:germ cell migration; IMP:FlyBase.
DR GO; GO:0007506; P:gonadal mesoderm development; IMP:FlyBase.
DR GO; GO:0007486; P:imaginal disc-derived female genitalia development; IMP:FlyBase.
DR GO; GO:0030539; P:male genitalia development; IMP:FlyBase.
DR GO; GO:0008584; P:male gonad development; IMP:FlyBase.
DR GO; GO:0048094; P:male pigmentation; IDA:FlyBase.
DR GO; GO:0007494; P:midgut development; TAS:FlyBase.
DR GO; GO:0009997; P:negative regulation of cardioblast cell fate specification; IMP:FlyBase.
DR GO; GO:0007621; P:negative regulation of female receptivity; IMP:FlyBase.
DR GO; GO:0045705; P:negative regulation of salivary gland boundary specification; TAS:FlyBase.
DR GO; GO:0045843; P:negative regulation of striated muscle tissue development; IMP:FlyBase.
DR GO; GO:0061101; P:neuroendocrine cell differentiation; IMP:FlyBase.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0007280; P:pole cell migration; TAS:FlyBase.
DR GO; GO:1902339; P:positive regulation of apoptotic process involved in morphogenesis; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007379; P:segment specification; IMP:FlyBase.
DR GO; GO:0007385; P:specification of segmental identity, abdomen; IMP:FlyBase.
DR GO; GO:0046693; P:sperm storage; IMP:FlyBase.
DR GO; GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Developmental protein; DNA-binding;
KW Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..493
FT /note="Homeobox protein abdominal-B"
FT /id="PRO_0000200258"
FT DNA_BIND 387..446
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..51
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..223
FT /note="Missing (in isoform R)"
FT /evidence="ECO:0000305"
FT /id="VSP_002396"
FT CONFLICT 15
FT /note="Q -> H (in Ref. 4; CAB57859)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="Missing (in Ref. 3; CAA34260)"
FT /evidence="ECO:0000305"
FT CONFLICT 177..180
FT /note="ASGA -> PVR (in Ref. 3; CAA34260)"
FT /evidence="ECO:0000305"
FT CONFLICT 317..318
FT /note="ER -> DG (in Ref. 3; CAA34260)"
FT /evidence="ECO:0000305"
FT HELIX 380..382
FT /evidence="ECO:0007829|PDB:5ZJT"
FT HELIX 396..408
FT /evidence="ECO:0007829|PDB:5ZJT"
FT HELIX 414..423
FT /evidence="ECO:0007829|PDB:5ZJT"
FT HELIX 428..444
FT /evidence="ECO:0007829|PDB:5ZJT"
SQ SEQUENCE 493 AA; 55096 MW; 55A11B5E97983A5F CRC64;
MQQHHLQQQQ QQQQQQEQQH LQEQQQHLQQ LHHHAHHHLP QPLHTTSHHH SAHPHLQQQQ
QQQQHAVVAS SPSSVLQQQQ QQSTPTTHST PTHAVMYEDP PPVPLVAVQQ QHLPAPQQQQ
QLQQQQQQQQ QQLATTPVAG ALSPAQTPTG PSAQQQQHLT SPHHQQLPQQ QTPNSVASGA
SSNLQQQQQQ QNAAVAPGQT QIVAPTTASV SPSSVSSQKE DINMSIQLAP LHIPAIRAGP
GFETDTSAAV KRHTAHWAYN DEGFNQHYGS GYYDRKHMFA YPYPETQFPV GQYWGPNYRP
DQTTSAAAAA AYMNEAERHV SAAARQSVEG TSTSSYEPPT YSSPGGLRGY PSENYSSSGA
SGGLSVGAVG PCTPNPGLHE WTGQVSVRKK RKPYSKFQTL ELEKEFLFNA YVSKQKRWEL
ARNLQLTERQ VKIWFQNRRM KNKKNSQRQA NQQNNNNNSS SNHNHAQATQ QHHSGHHLNL
SLNMGHHAAK MHQ
