ID   SDHF1_YEAS7             Reviewed;          79 AA.
AC   A6ZYX9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Succinate dehydrogenase assembly factor 1, mitochondrial {ECO:0000250|UniProtKB:Q3E785};
DE            Short=SDH assembly factor 1 {ECO:0000250|UniProtKB:Q3E785};
DE            Short=SDHAF1 {ECO:0000250|UniProtKB:Q3E785};
GN   ORFNames=SCY_1267;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Plays an essential role in the assembly of succinate
CC       dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC       complex II) that is a component of both the tricarboxylic acid (TCA)
CC       cycle and the mitochondrial electron transport chain, and which couples
CC       the oxidation of succinate to fumarate with the reduction of ubiquinone
CC       (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur
CC       protein subunit SDH2 of the SDH catalytic dimer, protecting it from the
CC       deleterious effects of oxidants. Acts together with SDHAF3 (SDH7).
CC       {ECO:0000250|UniProtKB:Q3E785}.
CC   -!- SUBUNIT: Interacts with SDH2 within an SDH1-SDH2 subcomplex.
CC       {ECO:0000250|UniProtKB:Q3E785}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q3E785}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. SDHAF1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFW02000145; EDN60709.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZYX9; -.
DR   SMR; A6ZYX9; -.
DR   EnsemblFungi; EDN60709; EDN60709; SCY_1267.
DR   HOGENOM; CLU_154777_1_1_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IEA:InterPro.
DR   CDD; cd20268; Complex1_LYR_SDHAF1_LYRM8; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045295; Complex1_LYR_SDHAF1_LYRM8.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   3: Inferred from homology;
KW   Chaperone; Mitochondrion.
FT   CHAIN           1..79
FT                   /note="Succinate dehydrogenase assembly factor 1,
FT                   mitochondrial"
FT                   /id="PRO_0000327919"
SQ   SEQUENCE   79 AA;  9352 MW;  2A49008969061739 CRC64;
     MPKRLSGLQK EVLHLYRASI RTAHTKPKEN QVNFVNYIHE EFGKYRNLPR KDFTTIEHLL
     RVGNKKIATF SHPELTNIH