ID   SDHF2_BOVIN             Reviewed;         166 AA.
AC   Q3ZBC2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDH assembly factor 2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE   Flags: Precursor;
GN   Name=SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057};
GN   Synonyms=PGL2 {ECO:0000255|HAMAP-Rule:MF_03057},
GN   SDH5 {ECO:0000255|HAMAP-Rule:MF_03057};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in the assembly of succinate
CC       dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC       complex II) that is a component of both the tricarboxylic acid (TCA)
CC       cycle and the mitochondrial electron transport chain, and which couples
CC       the oxidation of succinate to fumarate with the reduction of ubiquinone
CC       (coenzyme Q) to ubiquinol. Required for flavinylation (covalent
CC       attachment of FAD) of the flavoprotein subunit SDHA of the SDH
CC       catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBUNIT: Interacts with SDHA within the SDH catalytic dimer.
CC       {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
CC   -!- SIMILARITY: Belongs to the SDHAF2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
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DR   EMBL; BC103446; AAI03447.1; -; mRNA.
DR   RefSeq; NP_001070513.1; NM_001077045.2.
DR   AlphaFoldDB; Q3ZBC2; -.
DR   SMR; Q3ZBC2; -.
DR   STRING; 9913.ENSBTAP00000020305; -.
DR   PaxDb; Q3ZBC2; -.
DR   PRIDE; Q3ZBC2; -.
DR   Ensembl; ENSBTAT00000020305; ENSBTAP00000020305; ENSBTAG00000015266.
DR   GeneID; 767983; -.
DR   KEGG; bta:767983; -.
DR   CTD; 54949; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015266; -.
DR   VGNC; VGNC:56278; SDHAF2.
DR   eggNOG; KOG3326; Eukaryota.
DR   GeneTree; ENSGT00390000001149; -.
DR   HOGENOM; CLU_103054_0_2_1; -.
DR   InParanoid; Q3ZBC2; -.
DR   OMA; YGKPQNP; -.
DR   OrthoDB; 1492851at2759; -.
DR   TreeFam; TF300175; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000015266; Expressed in tongue muscle and 103 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:Ensembl.
DR   GO; GO:0018293; P:protein-FAD linkage; ISS:UniProtKB.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 1.10.150.250; -; 1.
DR   HAMAP; MF_03057; SDHAF2; 1.
DR   InterPro; IPR005631; SDH.
DR   InterPro; IPR036714; SDH_sf.
DR   InterPro; IPR028882; SDHAF2.
DR   Pfam; PF03937; Sdh5; 1.
DR   SUPFAM; SSF109910; SSF109910; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..166
FT                   /note="Succinate dehydrogenase assembly factor 2,
FT                   mitochondrial"
FT                   /id="PRO_0000294356"
SQ   SEQUENCE   166 AA;  19604 MW;  D6CE06E30DD37519 CRC64;
     MAVVAVFPAL ARMLAVSRRR LVSPSLSMTS CRRCYRGDSP TDSQKDMIEI PLPPWQERTD
     ESIETKRARL LYESRKRGML ENCILLSLFA KEHLQHMTEK QLNLYDRLIN EPSNDWDIYY
     WATEAKPAPE IFENEVMTLL RDFAKNKNKE QRLRAPDLEY LFEKPH