SDHF2_CAEEL
ID SDHF2_CAEEL Reviewed; 119 AA.
AC Q9NA72;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057};
DE Short=SDH assembly factor 2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE Short=SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057};
GN ORFNames=Y57A10A.29;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays an essential role in the assembly of succinate
CC dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC complex II) that is a component of both the tricarboxylic acid (TCA)
CC cycle and the mitochondrial electron transport chain, and which couples
CC the oxidation of succinate to fumarate with the reduction of ubiquinone
CC (coenzyme Q) to ubiquinol. Required for flavinylation (covalent
CC attachment of FAD) of the flavoprotein subunit of the SDH catalytic
CC dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC -!- SUBUNIT: Interacts with the flavoprotein subunit within the SDH
CC catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-
CC Rule:MF_03057}.
CC -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC Rule:MF_03057}.
CC -!- SIMILARITY: Belongs to the SDHAF2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03057}.
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DR EMBL; AL117195; CAB55034.1; -; Genomic_DNA.
DR PIR; T31651; T31651.
DR RefSeq; NP_496607.1; NM_064206.4.
DR AlphaFoldDB; Q9NA72; -.
DR SMR; Q9NA72; -.
DR STRING; 6239.Y57A10A.29.2; -.
DR EPD; Q9NA72; -.
DR PaxDb; Q9NA72; -.
DR PeptideAtlas; Q9NA72; -.
DR EnsemblMetazoa; Y57A10A.29.1; Y57A10A.29.1; WBGene00013269.
DR GeneID; 174870; -.
DR KEGG; cel:CELE_Y57A10A.29; -.
DR UCSC; Y57A10A.29; c. elegans.
DR CTD; 174870; -.
DR WormBase; Y57A10A.29; CE22606; WBGene00013269; -.
DR eggNOG; KOG3326; Eukaryota.
DR GeneTree; ENSGT00390000001149; -.
DR HOGENOM; CLU_103054_1_0_1; -.
DR InParanoid; Q9NA72; -.
DR OMA; HMEWDLF; -.
DR OrthoDB; 1492851at2759; -.
DR PhylomeDB; Q9NA72; -.
DR PRO; PR:Q9NA72; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013269; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR GO; GO:0018293; P:protein-FAD linkage; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 1.10.150.250; -; 1.
DR HAMAP; MF_03057; SDHAF2; 1.
DR InterPro; IPR005631; SDH.
DR InterPro; IPR036714; SDH_sf.
DR InterPro; IPR028882; SDHAF2.
DR Pfam; PF03937; Sdh5; 1.
DR SUPFAM; SSF109910; SSF109910; 1.
PE 3: Inferred from homology;
KW Chaperone; Mitochondrion; Reference proteome.
FT CHAIN 1..119
FT /note="Succinate dehydrogenase assembly factor 2,
FT mitochondrial"
FT /id="PRO_0000383185"
SQ SEQUENCE 119 AA; 13946 MW; 74EBAA57809C26C6 CRC64;
MTSRILQRFF TVSTSLRSLT RAEVPGEKID AKRARLLYQS KKRGILENDI LLGDFAEQNL
KKMSEPELKA YDKLINGEHM EWDLFYYLSN KKSPPEDVES CQVYQKVKKF VDDKRVPKS
