SDHF2_DANRE
ID SDHF2_DANRE Reviewed; 158 AA.
AC A3KP74;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057};
DE Short=SDH assembly factor 2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE Short=SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE Flags: Precursor;
GN Name=sdhaf2 {ECO:0000255|HAMAP-Rule:MF_03057}; Synonyms=pgl2, sdh5;
GN ORFNames=zgc:163000;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larval eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an essential role in the assembly of succinate
CC dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC complex II) that is a component of both the tricarboxylic acid (TCA)
CC cycle and the mitochondrial electron transport chain, and which couples
CC the oxidation of succinate to fumarate with the reduction of ubiquinone
CC (coenzyme Q) to ubiquinol. Required for flavinylation (covalent
CC attachment of FAD) of the flavoprotein subunit sdha of the SDH
CC catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC -!- SUBUNIT: Interacts with sdha within the SDH catalytic dimer.
CC {ECO:0000255|HAMAP-Rule:MF_03057}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-
CC Rule:MF_03057}.
CC -!- SIMILARITY: Belongs to the SDHAF2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03057}.
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DR EMBL; BC134190; AAI34191.1; -; mRNA.
DR RefSeq; NP_001076333.1; NM_001082864.1.
DR AlphaFoldDB; A3KP74; -.
DR SMR; A3KP74; -.
DR STRING; 7955.ENSDARP00000086049; -.
DR PaxDb; A3KP74; -.
DR PeptideAtlas; A3KP74; -.
DR Ensembl; ENSDART00000091616; ENSDARP00000086049; ENSDARG00000062971.
DR Ensembl; ENSDART00000191904; ENSDARP00000144692; ENSDARG00000114840.
DR GeneID; 569482; -.
DR KEGG; dre:569482; -.
DR CTD; 54949; -.
DR ZFIN; ZDB-GENE-030131-7564; sdhaf2.
DR eggNOG; KOG3326; Eukaryota.
DR GeneTree; ENSGT00390000001149; -.
DR HOGENOM; CLU_103054_0_2_1; -.
DR InParanoid; A3KP74; -.
DR OMA; YGKPQNP; -.
DR OrthoDB; 1492851at2759; -.
DR PhylomeDB; A3KP74; -.
DR TreeFam; TF300175; -.
DR PRO; PR:A3KP74; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000062971; Expressed in cardiac ventricle and 25 other tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; ISS:UniProtKB.
DR GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR GO; GO:0018293; P:protein-FAD linkage; ISS:UniProtKB.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 1.10.150.250; -; 1.
DR HAMAP; MF_03057; SDHAF2; 1.
DR InterPro; IPR005631; SDH.
DR InterPro; IPR036714; SDH_sf.
DR InterPro; IPR028882; SDHAF2.
DR Pfam; PF03937; Sdh5; 1.
DR SUPFAM; SSF109910; SSF109910; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..17
FT /note="Mitochondrion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03057"
FT CHAIN 18..158
FT /note="Succinate dehydrogenase assembly factor 2,
FT mitochondrial"
FT /id="PRO_0000294361"
SQ SEQUENCE 158 AA; 18476 MW; 63DF11C46CE2BEBD CRC64;
MFSANIARKV VCSVCRASLR PTVCPVVYRG YRGDAPEPTI LEIPLPPWQE RAGEALDIKR
KRLLYESRKR GMLENCILLS LFAKQYLNTM SESQLKQYDR LINEPSNDWD IYYWATDTQP
TPEVYQGEVM DMLKEFTKNR DMEQRLDAPN LEYLDKSS
