ID   SDHF2_RAT               Reviewed;         164 AA.
AC   Q5RJQ7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDH assembly factor 2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE            Short=SDHAF2 {ECO:0000255|HAMAP-Rule:MF_03057};
DE   Flags: Precursor;
GN   Name=Sdhaf2 {ECO:0000255|HAMAP-Rule:MF_03057};
GN   Synonyms=Pgl2 {ECO:0000255|HAMAP-Rule:MF_03057},
GN   Sdh5 {ECO:0000255|HAMAP-Rule:MF_03057};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an essential role in the assembly of succinate
CC       dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC       complex II) that is a component of both the tricarboxylic acid (TCA)
CC       cycle and the mitochondrial electron transport chain, and which couples
CC       the oxidation of succinate to fumarate with the reduction of ubiquinone
CC       (coenzyme Q) to ubiquinol. Required for flavinylation (covalent
CC       attachment of FAD) of the flavoprotein subunit SDHA of the SDH
CC       catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBUNIT: Interacts with SDHA within the SDH catalytic dimer.
CC       {ECO:0000255|HAMAP-Rule:MF_03057}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
CC   -!- SIMILARITY: Belongs to the SDHAF2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03057}.
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DR   EMBL; BC086542; AAH86542.1; -; mRNA.
DR   RefSeq; NP_001008372.1; NM_001008371.1.
DR   AlphaFoldDB; Q5RJQ7; -.
DR   SMR; Q5RJQ7; -.
DR   STRING; 10116.ENSRNOP00000028028; -.
DR   PhosphoSitePlus; Q5RJQ7; -.
DR   PaxDb; Q5RJQ7; -.
DR   Ensembl; ENSRNOT00000028028; ENSRNOP00000028028; ENSRNOG00000020646.
DR   GeneID; 361726; -.
DR   KEGG; rno:361726; -.
DR   UCSC; RGD:1309216; rat.
DR   CTD; 54949; -.
DR   RGD; 1309216; Sdhaf2.
DR   eggNOG; KOG3326; Eukaryota.
DR   GeneTree; ENSGT00390000001149; -.
DR   HOGENOM; CLU_103054_0_2_1; -.
DR   InParanoid; Q5RJQ7; -.
DR   OMA; YGKPQNP; -.
DR   OrthoDB; 1492851at2759; -.
DR   PhylomeDB; Q5RJQ7; -.
DR   TreeFam; TF300175; -.
DR   PRO; PR:Q5RJQ7; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020646; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q5RJQ7; RN.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR   GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:RGD.
DR   GO; GO:0006470; P:protein dephosphorylation; ISO:RGD.
DR   GO; GO:0018293; P:protein-FAD linkage; ISS:UniProtKB.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 1.10.150.250; -; 1.
DR   HAMAP; MF_03057; SDHAF2; 1.
DR   InterPro; IPR005631; SDH.
DR   InterPro; IPR036714; SDH_sf.
DR   InterPro; IPR028882; SDHAF2.
DR   Pfam; PF03937; Sdh5; 1.
DR   SUPFAM; SSF109910; SSF109910; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..27
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..164
FT                   /note="Succinate dehydrogenase assembly factor 2,
FT                   mitochondrial"
FT                   /id="PRO_0000294360"
SQ   SEQUENCE   164 AA;  19524 MW;  9CBE582352281AA0 CRC64;
     MAVVTLIPTL ARVLSKHSLL SPLLSVTSFR RFYRGDSPTD SQKDMIEIPL PPWQERTDES
     IETKRARLLY ESRKRGMLEN CILLSLFAKE YLHNMTEKQL NLYDRLINEP SNDWDIYYWA
     TEAKPAPEIF ENEVMELLRE FTKNKNKEQR LRAPDLEYLF EKPR