SDHF3_BOVIN
ID SDHF3_BOVIN Reviewed; 125 AA.
AC Q0P574;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Succinate dehydrogenase assembly factor 3, mitochondrial {ECO:0000250|UniProtKB:Q04401};
DE Short=SDH assembly factor 3 {ECO:0000250|UniProtKB:Q04401};
DE Short=SDHAF3 {ECO:0000250|UniProtKB:Q04401};
DE Flags: Precursor;
GN Name=SDHAF3 {ECO:0000250|UniProtKB:Q9NRP4};
GN Synonyms=ACN9 {ECO:0000250|UniProtKB:Q9NRP4};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an essential role in the assembly of succinate
CC dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC complex II) that is a component of both the tricarboxylic acid (TCA)
CC cycle and the mitochondrial electron transport chain, and which couples
CC the oxidation of succinate to fumarate with the reduction of ubiquinone
CC (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur
CC protein subunit SDHB of the SDH catalytic dimer, protecting it from the
CC deleterious effects of oxidants. May act together with SDHAF1.
CC {ECO:0000250|UniProtKB:Q04401, ECO:0000250|UniProtKB:Q8SZ16}.
CC -!- SUBUNIT: Interacts with SDHB within an SDHA-SDHB subcomplex.
CC {ECO:0000250|UniProtKB:Q04401}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q04401}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. SDHAF3 subfamily.
CC {ECO:0000305}.
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DR EMBL; BC120424; AAI20425.1; -; mRNA.
DR RefSeq; NP_001073821.1; NM_001080352.1.
DR AlphaFoldDB; Q0P574; -.
DR SMR; Q0P574; -.
DR STRING; 9913.ENSBTAP00000021172; -.
DR PaxDb; Q0P574; -.
DR Ensembl; ENSBTAT00000021172; ENSBTAP00000021172; ENSBTAG00000015925.
DR GeneID; 783805; -.
DR KEGG; bta:783805; -.
DR CTD; 57001; -.
DR VEuPathDB; HostDB:ENSBTAG00000015925; -.
DR VGNC; VGNC:34390; SDHAF3.
DR eggNOG; KOG4100; Eukaryota.
DR GeneTree; ENSGT00940000164236; -.
DR HOGENOM; CLU_102310_2_1_1; -.
DR InParanoid; Q0P574; -.
DR OMA; LTEWQMY; -.
DR OrthoDB; 1613308at2759; -.
DR TreeFam; TF105635; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000015925; Expressed in oocyte and 106 other tissues.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR GO; GO:0006105; P:succinate metabolic process; IBA:GO_Central.
DR InterPro; IPR008381; SDHAF3/Sdh7.
DR PANTHER; PTHR13137; PTHR13137; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 31..125
FT /note="Succinate dehydrogenase assembly factor 3,
FT mitochondrial"
FT /id="PRO_0000328458"
SQ SEQUENCE 125 AA; 14754 MW; 6D346FE5DAA5EEB4 CRC64;
MSALHVSRVR ALYRRILLLH RVLPPDLKDL GDRYVKDEFR RHKTAGSKEA ERFLQEWEAY
AAVLWQQANE SRQNSTEKAC FGISLPEEKL NDFRDEQIGQ LQELMQEATK PNRQFNITES
RKPKL