SDHF4_DICDI
ID SDHF4_DICDI Reviewed; 108 AA.
AC Q54Y25;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Succinate dehydrogenase assembly factor 4, mitochondrial {ECO:0000250|UniProtKB:P38345};
DE Short=SDH assembly factor 4 {ECO:0000250|UniProtKB:P38345};
DE Short=SDHAF4 {ECO:0000250|UniProtKB:P38345};
GN ORFNames=DDB_G0278459;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Plays an essential role in the assembly of succinate
CC dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC complex II) that is a component of both the tricarboxylic acid (TCA)
CC cycle and the mitochondrial electron transport chain, and which couples
CC the oxidation of succinate to fumarate with the reduction of ubiquinone
CC (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SdhA in
CC its FAD-bound form, blocking the generation of excess reactive oxigen
CC species (ROS) and facilitating its assembly with the iron-sulfur
CC protein subunit SdhB into the SDH catalytic dimer.
CC {ECO:0000250|UniProtKB:P38345}.
CC -!- SUBUNIT: Interacts with SdhA in its FAD-bound form.
CC {ECO:0000250|UniProtKB:P38345}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:P38345}.
CC -!- SIMILARITY: Belongs to the SDHAF4 family. {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68402.1; -; Genomic_DNA.
DR RefSeq; XP_642377.1; XM_637285.1.
DR AlphaFoldDB; Q54Y25; -.
DR STRING; 44689.DDB0205467; -.
DR PaxDb; Q54Y25; -.
DR EnsemblProtists; EAL68402; EAL68402; DDB_G0278459.
DR GeneID; 8621582; -.
DR KEGG; ddi:DDB_G0278459; -.
DR dictyBase; DDB_G0278459; -.
DR eggNOG; KOG3245; Eukaryota.
DR HOGENOM; CLU_160299_0_2_1; -.
DR InParanoid; Q54Y25; -.
DR OMA; AQYSKEH; -.
DR PRO; PR:Q54Y25; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR InterPro; IPR012875; SDHF4.
DR Pfam; PF07896; DUF1674; 1.
PE 3: Inferred from homology;
KW Chaperone; Mitochondrion; Reference proteome.
FT CHAIN 1..108
FT /note="Succinate dehydrogenase assembly factor 4,
FT mitochondrial"
FT /id="PRO_0000333284"
FT REGION 33..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 108 AA; 12595 MW; 1DEA8398060B4414 CRC64;
MNNLISKFNK IIYLNATKQT NKINCSFYST TINNNNNNNN NNNNNNISNK KAEMSKENQQ
LLQDLEEEFD EDEFKPYVNP ITKEIGGPKG PEPTRYNDWE RNGRVSDF
