ID   SDHFA_DICDI             Reviewed;          91 AA.
AC   Q54HG5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Succinate dehydrogenase assembly factor 1A, mitochondrial {ECO:0000250|UniProtKB:A6NFY7};
DE            Short=SDH assembly factor 1A {ECO:0000250|UniProtKB:A6NFY7};
DE            Short=SDHAF1A {ECO:0000250|UniProtKB:A6NFY7};
GN   Name=sdhaf1A {ECO:0000312|dictyBase:DDB_G0289475}; ORFNames=DDB_G0289475;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays an essential role in the assembly of succinate
CC       dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC       complex II) that is a component of both the tricarboxylic acid (TCA)
CC       cycle and the mitochondrial electron transport chain, and which couples
CC       the oxidation of succinate to fumarate with the reduction of ubiquinone
CC       (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur
CC       protein subunit of the SDH catalytic dimer, protecting it from the
CC       deleterious effects of oxidants. May act together with SDHAF3.
CC       {ECO:0000250|UniProtKB:A6NFY7}.
CC   -!- SUBUNIT: Interacts with the iron-sulfur protein subunit within the SDH
CC       catalytic dimer. {ECO:0000250|UniProtKB:Q3E785}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:A6NFY7}.
CC   -!- SIMILARITY: Belongs to the complex I LYR family. SDHAF1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000141; EAL62717.1; -; Genomic_DNA.
DR   RefSeq; XP_636220.1; XM_631128.1.
DR   AlphaFoldDB; Q54HG5; -.
DR   SMR; Q54HG5; -.
DR   PaxDb; Q54HG5; -.
DR   EnsemblProtists; EAL62717; EAL62717; DDB_G0289475.
DR   GeneID; 8627158; -.
DR   KEGG; ddi:DDB_G0289475; -.
DR   dictyBase; DDB_G0289475; sdhaf1A.
DR   eggNOG; ENOG502SCH5; Eukaryota.
DR   HOGENOM; CLU_154777_0_0_1; -.
DR   InParanoid; Q54HG5; -.
DR   OMA; ISTIEFM; -.
DR   PhylomeDB; Q54HG5; -.
DR   PRO; PR:Q54HG5; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IBA:GO_Central.
DR   CDD; cd20268; Complex1_LYR_SDHAF1_LYRM8; 1.
DR   InterPro; IPR008011; Complex1_LYR_dom.
DR   InterPro; IPR045295; Complex1_LYR_SDHAF1_LYRM8.
DR   Pfam; PF05347; Complex1_LYR; 1.
PE   3: Inferred from homology;
KW   Chaperone; Mitochondrion; Reference proteome.
FT   CHAIN           1..91
FT                   /note="Succinate dehydrogenase assembly factor 1A,
FT                   mitochondrial"
FT                   /id="PRO_0000327918"
SQ   SEQUENCE   91 AA;  10459 MW;  4331106EF4387182 CRC64;
     MNTTPIRHSG LQKAVLSLYR SFLRVSNKKE MDNPSSSISN YIKTQFRLKA TTIQKRDINK
     IESLLVKGKR QLEQIQDPEF SGFAVFTPKS K