SDHFB_DICDI
ID SDHFB_DICDI Reviewed; 111 AA.
AC Q55BM0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Succinate dehydrogenase assembly factor 1B, mitochondrial {ECO:0000250|UniProtKB:A6NFY7};
DE Short=SDH assembly factor 1B {ECO:0000250|UniProtKB:A6NFY7};
DE Short=SDHAF1B {ECO:0000250|UniProtKB:A6NFY7};
GN Name=sdhaf1B {ECO:0000312|dictyBase:DDB_G0270818}; ORFNames=DDB_G0270818;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Plays an essential role in the assembly of succinate
CC dehydrogenase (SDH), an enzyme complex (also referred to as respiratory
CC complex II) that is a component of both the tricarboxylic acid (TCA)
CC cycle and the mitochondrial electron transport chain, and which couples
CC the oxidation of succinate to fumarate with the reduction of ubiquinone
CC (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur
CC protein subunit of the SDH catalytic dimer, protecting it from the
CC deleterious effects of oxidants. May act together with SDHAF3.
CC {ECO:0000250|UniProtKB:A6NFY7}.
CC -!- SUBUNIT: Interacts with the iron-sulfur protein subunit within the SDH
CC catalytic dimer. {ECO:0000250|UniProtKB:Q3E785}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:A6NFY7}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. SDHAF1 subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72759.1; -; Genomic_DNA.
DR RefSeq; XP_646810.1; XM_641718.1.
DR AlphaFoldDB; Q55BM0; -.
DR PaxDb; Q55BM0; -.
DR EnsemblProtists; EAL72759; EAL72759; DDB_G0270818.
DR GeneID; 8617782; -.
DR KEGG; ddi:DDB_G0270818; -.
DR dictyBase; DDB_G0270818; sdhaf1B.
DR eggNOG; ENOG502S56S; Eukaryota.
DR HOGENOM; CLU_2163165_0_0_1; -.
DR InParanoid; Q55BM0; -.
DR OMA; YSAKRCP; -.
DR PRO; PR:Q55BM0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0034553; P:mitochondrial respiratory chain complex II assembly; IEA:InterPro.
DR CDD; cd20268; Complex1_LYR_SDHAF1_LYRM8; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045295; Complex1_LYR_SDHAF1_LYRM8.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 3: Inferred from homology;
KW Chaperone; Mitochondrion; Reference proteome.
FT CHAIN 1..111
FT /note="Succinate dehydrogenase assembly factor 1B,
FT mitochondrial"
FT /id="PRO_0000383347"
SQ SEQUENCE 111 AA; 13233 MW; 3B15795AC27AFAAE CRC64;
MSSKIIKENK RLVLDLYKRC LYSAKRCPKY QNQMMMESYI KLKFRSNKEI HQKDFETIEN
LLKQGEEELK SMNDFHELRA KSKSGQDHES ILNDCFDDDF NYIGSTPTVK K