ID   SDHL_HAEIN              Reviewed;         455 AA.
AC   P71349;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=L-serine dehydratase;
DE            Short=SDH;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
DE            Short=L-SD;
GN   Name=sdaA; OrderedLocusNames=HI_0288;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.;
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000305};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21953.1; -; Genomic_DNA.
DR   RefSeq; NP_438455.1; NC_000907.1.
DR   RefSeq; WP_005693026.1; NC_000907.1.
DR   AlphaFoldDB; P71349; -.
DR   SMR; P71349; -.
DR   STRING; 71421.HI_0288; -.
DR   EnsemblBacteria; AAC21953; AAC21953; HI_0288.
DR   KEGG; hin:HI_0288; -.
DR   PATRIC; fig|71421.8.peg.304; -.
DR   eggNOG; COG1760; Bacteria.
DR   HOGENOM; CLU_022305_0_1_6; -.
DR   OMA; SAAMGGC; -.
DR   PhylomeDB; P71349; -.
DR   BioCyc; HINF71421:G1GJ1-306-MON; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   TIGRFAMs; TIGR00720; sda_mono; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..455
FT                   /note="L-serine dehydratase"
FT                   /id="PRO_0000171906"
SQ   SEQUENCE   455 AA;  49538 MW;  11002A51736DD386 CRC64;
     MISVFDMFKV GIGPSSSHTV GPMKAGKQFI DDLIKRNQFE QTTEIHVDVY GSLSMTGRGH
     STDIAIIMGL AGYLPHNVDI DMISGFIEKV KQTALLPINV GQKIVKFDFE NNLIFHRTFL
     KLHENGMTIT ALDENRTELY RQTYYSIGGG FIVDEAHFGK EEKNTVQVPY PYKNAEDILK
     HCSDNGLMLS TVMLENEIAL NGKEAVSAHL ENVWKTMQAC IEHGIHTEGI LPGPLRVPRR
     AASLYRALQA NTNLSNDPMR VIDWVNMFAL AVNEENAAGG RVVTAPTNGA CGIIPAVLAY
     YEKFISPLTP EIIERYLLAA GMIGSLYKMN ASISGAEVGC QGEVGVACSM AAAGLAEILG
     GNPLQVCIAA EIAMEHNLGL TCDPVGGQVQ VPCIERNAIA SVKAINASRM ALRRTTNPRV
     TLDKVIETMY ETGKDMNAKY RETSQGGLAV KIVCN