ID   SDHL_HELPY              Reviewed;         455 AA.
AC   P56072;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=L-serine dehydratase;
DE            Short=SDH;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
DE            Short=L-SD;
GN   Name=sdaA; OrderedLocusNames=HP_0132;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000305};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000305};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07202.1; -; Genomic_DNA.
DR   PIR; D64536; D64536.
DR   RefSeq; NP_206932.1; NC_000915.1.
DR   RefSeq; WP_000135967.1; NC_018939.1.
DR   AlphaFoldDB; P56072; -.
DR   SMR; P56072; -.
DR   DIP; DIP-3172N; -.
DR   IntAct; P56072; 8.
DR   MINT; P56072; -.
DR   STRING; 85962.C694_00650; -.
DR   PaxDb; P56072; -.
DR   EnsemblBacteria; AAD07202; AAD07202; HP_0132.
DR   KEGG; hpy:HP_0132; -.
DR   PATRIC; fig|85962.47.peg.143; -.
DR   eggNOG; COG1760; Bacteria.
DR   OMA; SAAMGGC; -.
DR   PhylomeDB; P56072; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   TIGRFAMs; TIGR00720; sda_mono; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..455
FT                   /note="L-serine dehydratase"
FT                   /id="PRO_0000171907"
SQ   SEQUENCE   455 AA;  49242 MW;  4F5B5067C1DB0DC7 CRC64;
     MASFSILSIF KIGVGPSSSH TIGPMEAGAR FCESLKGILE QVVRVQITLH GSLALTGKGH
     LSDEAVLIGL HGIYANELEV TTKKALLHEA LENKVLKLAN QHHIPFDYAK DLIFDNKPLT
     RHQNALILKA FNSKNEVLKE ETYYSVGGGF VYTEKELDNL SEEDGNESIA YDFSSAKELL
     ELCQKHQKSI AEIVRLRENA LKNHPDATMV KIYHAMLECY DNGANSKERY LPGSLKVTRL
     APSIKTRLEK HPTSGKDPLA LIDYISLYAR AIAEENASGG KVVTAPTNGA CAVVPSVLLY
     AKNHLFENLS QKAINDFLLT SAAIGYLYKK NASLSGAEAG CQAEIGVASS MAAGGLAHLC
     QATTQQVLIA SEIAMEHHLG LTCDPVGGLV QIPCIERNVL GAIKAISASK LALEDEYKPK
     VSLDEVIATM YATGKDMNEK YKETSLGGLA KTLKC