ID   SDHL_MYCTU              Reviewed;         461 AA.
AC   P9WGT5; L0T5F2; O53614; P66773;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=L-serine dehydratase;
DE            Short=SDH;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
DE            Short=L-SD;
GN   Name=sdaA; OrderedLocusNames=Rv0069c; ORFNames=MTV030.12c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine = NH4(+) + pyruvate; Xref=Rhea:RHEA:19169,
CC         ChEBI:CHEBI:15361, ChEBI:CHEBI:28938, ChEBI:CHEBI:33384; EC=4.3.1.17;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP42792.1; -; Genomic_DNA.
DR   PIR; F70848; F70848.
DR   RefSeq; NP_214583.1; NC_000962.3.
DR   RefSeq; WP_003400600.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WGT5; -.
DR   SMR; P9WGT5; -.
DR   STRING; 83332.Rv0069c; -.
DR   PaxDb; P9WGT5; -.
DR   DNASU; 886986; -.
DR   GeneID; 45424031; -.
DR   GeneID; 886986; -.
DR   KEGG; mtu:Rv0069c; -.
DR   TubercuList; Rv0069c; -.
DR   eggNOG; COG1760; Bacteria.
DR   OMA; ELHRDTY; -.
DR   PhylomeDB; P9WGT5; -.
DR   UniPathway; UPA00138; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR004644; Fe-S_L-Ser_mono.
DR   InterPro; IPR005130; Ser_deHydtase-like_asu.
DR   InterPro; IPR005131; Ser_deHydtase_bsu.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   Pfam; PF03315; SDH_beta; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   TIGRFAMs; TIGR00720; sda_mono; 1.
PE   1: Evidence at protein level;
KW   4Fe-4S; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding;
KW   Reference proteome.
FT   CHAIN           1..461
FT                   /note="L-serine dehydratase"
FT                   /id="PRO_0000171909"
SQ   SEQUENCE   461 AA;  48576 MW;  228C62DCE67FEAFD CRC64;
     MTISVFDLFT IGIGPSSSHT VGPMRAANQF VVALRRRGHL DDLEAMRVDL FGSLAATGAG
     HGTMSAILLG LEGCQPETIT TEHKERRLAE IAASGVTRIG GVIPVPLTER DIDLHPDIVL
     PTHPNGMTFT AAGPHGRVLA TETYFSVGGG FIVTEQTSGN SGQHPCSVAL PYVSAQELLD
     ICDRLDVSIS EAALRNETCC RTENEVRAAL LHLRDVMVEC EQRSIAREGL LPGGLRVRRR
     AKVWYDRLNA EDPTRKPEFA EDWVNLVALA VNEENASGGR VVTAPTNGAA GIVPAVLHYA
     IHYTSAGAGD PDDVTVRFLL TAGAIGSLFK ERASISGAEV GCQGEVGSAA AMAAAGLAEI
     LGGTPRQVEN AAEIAMEHSL GLTCDPIAGL VQIPCIERNA ISAGKAINAA RMALRGDGIH
     RVTLDQVIDT MRATGADMHT KYKETSAGGL AINVAVNIVE C