BFD_ECOLI
ID BFD_ECOLI Reviewed; 64 AA.
AC P0AE56; O68930; P13655; Q2M702;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Bacterioferritin-associated ferredoxin;
GN Name=bfd; Synonyms=yheA; OrderedLocusNames=b3337, JW3299;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2661540; DOI=10.1128/jb.171.7.3940-3947.1989;
RA Andrews S.C., Harrison P.M., Guest J.R.;
RT "Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of
RT Escherichia coli K-12.";
RL J. Bacteriol. 171:3940-3947(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ECOR 30;
RA Noorani S.M., Lindahl L., Zengel J.M.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP CHARACTERIZATION.
RX PubMed=8639572; DOI=10.1021/bi9600862;
RA Garg R.P., Vargo C.J., Cui X., Kurtz D.M. Jr.;
RT "A [2Fe-2S] protein encoded by an open reading frame upstream of the
RT Escherichia coli bacterioferritin gene.";
RL Biochemistry 35:6297-6301(1996).
RN [6]
RP CHARACTERIZATION.
RX PubMed=8954950; DOI=10.1006/bbrc.1996.1856;
RA Quail M.A., Jordan P., Grogan J.M., Butt J.N., Lutz M., Thomson A.J.,
RA Andrews S.C., Guest J.R.;
RT "Spectroscopic and voltammetric characterisation of the bacterioferritin-
RT associated ferredoxin of Escherichia coli.";
RL Biochem. Biophys. Res. Commun. 229:635-642(1996).
CC -!- FUNCTION: Seems to associate with BFR; could be a general redox and/or
CC regulatory component participating in the iron storage mobilization
CC functions of BFR. Could participate in the release or the delivery of
CC iron from/to bacterioferritin (or other iron complexes).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Note=Binds 1 [2Fe-2S] cluster.;
CC -!- SUBUNIT: Monomer.
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DR EMBL; M27176; AAC13986.1; -; mRNA.
DR EMBL; AF058450; AAC14287.1; -; Genomic_DNA.
DR EMBL; U18997; AAA58134.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76362.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77954.1; -; Genomic_DNA.
DR PIR; JV0033; QQECB7.
DR RefSeq; NP_417796.1; NC_000913.3.
DR RefSeq; WP_000289085.1; NZ_STEB01000038.1.
DR AlphaFoldDB; P0AE56; -.
DR SMR; P0AE56; -.
DR BioGRID; 4262467; 8.
DR IntAct; P0AE56; 1.
DR STRING; 511145.b3337; -.
DR PaxDb; P0AE56; -.
DR PRIDE; P0AE56; -.
DR EnsemblBacteria; AAC76362; AAC76362; b3337.
DR EnsemblBacteria; BAE77954; BAE77954; BAE77954.
DR GeneID; 58459568; -.
DR GeneID; 947836; -.
DR KEGG; ecj:JW3299; -.
DR KEGG; eco:b3337; -.
DR PATRIC; fig|1411691.4.peg.3394; -.
DR EchoBASE; EB1168; -.
DR eggNOG; COG2906; Bacteria.
DR HOGENOM; CLU_159205_3_4_6; -.
DR InParanoid; P0AE56; -.
DR OMA; MYVCLCE; -.
DR PhylomeDB; P0AE56; -.
DR BioCyc; EcoCyc:EG11181-MON; -.
DR PRO; PR:P0AE56; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:EcoCyc.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.1100; -; 1.
DR InterPro; IPR007419; BFD-like_2Fe2S-bd_dom.
DR InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR Pfam; PF04324; Fer2_BFD; 1.
PE 1: Evidence at protein level;
KW 2Fe-2S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Transport.
FT CHAIN 1..64
FT /note="Bacterioferritin-associated ferredoxin"
FT /id="PRO_0000064914"
FT BINDING 4
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 6
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 39
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 42
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT VARIANT 9
FT /note="I -> V (in strain: ECOR 30)"
FT VARIANT 22..24
FT /note="SPH -> HPQ (in strain: ECOR 30)"
FT VARIANT 30
FT /note="K -> R (in strain: ECOR 30)"
FT VARIANT 43
FT /note="V -> I (in strain: ECOR 30)"
FT VARIANT 51
FT /note="E -> Q (in strain: ECOR 30)"
FT VARIANT 57
FT /note="L -> M (in strain: ECOR 30)"
FT VARIANT 63
FT /note="S -> I (in strain: ECOR 30)"
SQ SEQUENCE 64 AA; 7363 MW; 38D645EB15F7DE9E CRC64;
MYVCLCNGIS DKKIRQAVRQ FSPHSFQQLK KFIPVGNQCG KCVRAAREVM EDELMQLPEF
KESA
