SDN4_ARATH
ID SDN4_ARATH Reviewed; 322 AA.
AC Q9SN09;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Putative small RNA degrading nuclease 4;
DE EC=3.1.-.-;
GN Name=SDN4; OrderedLocusNames=At3g50090; ORFNames=F3A4.170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION, AND DISRUPTION PHENOTYPE.
RX PubMed=18787168; DOI=10.1126/science.1163728;
RA Ramachandran V., Chen X.;
RT "Degradation of microRNAs by a family of exoribonucleases in Arabidopsis.";
RL Science 321:1490-1492(2008).
CC -!- FUNCTION: Putative 3'-5' exonuclease degrading single-stranded small
CC RNAs.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Plants do not show a phenotype alteration due to
CC the redundancy with other SDN ribonucleases.
CC {ECO:0000269|PubMed:18787168}.
CC -!- SIMILARITY: Belongs to the REXO1/REXO3 family. {ECO:0000305}.
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DR EMBL; AL132978; CAB62117.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78625.1; -; Genomic_DNA.
DR PIR; T45862; T45862.
DR RefSeq; NP_190578.1; NM_114869.1.
DR AlphaFoldDB; Q9SN09; -.
DR SMR; Q9SN09; -.
DR STRING; 3702.AT3G50090.1; -.
DR PaxDb; Q9SN09; -.
DR PRIDE; Q9SN09; -.
DR EnsemblPlants; AT3G50090.1; AT3G50090.1; AT3G50090.
DR GeneID; 824171; -.
DR Gramene; AT3G50090.1; AT3G50090.1; AT3G50090.
DR KEGG; ath:AT3G50090; -.
DR Araport; AT3G50090; -.
DR TAIR; locus:2083153; AT3G50090.
DR eggNOG; KOG2248; Eukaryota.
DR HOGENOM; CLU_030142_0_0_1; -.
DR InParanoid; Q9SN09; -.
DR OMA; FLHRIPH; -.
DR OrthoDB; 839325at2759; -.
DR PhylomeDB; Q9SN09; -.
DR PRO; PR:Q9SN09; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SN09; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004527; F:exonuclease activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Exonuclease; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1..322
FT /note="Putative small RNA degrading nuclease 4"
FT /id="PRO_0000355087"
FT DOMAIN 75..213
FT /note="Exonuclease"
SQ SEQUENCE 322 AA; 36215 MW; 73BC3AB2CBB811E1 CRC64;
MDYLQAMRLR EANRLMIAKF KKESPANDSP EQRLVRLTNE NPQYNVDFLF HSYSKDWFVS
DVGMKMSNVM IPNQMLALDC EMVLCEDGTE GVVRVGAVDR NLKVILDEFV KPHKPVVDYR
TAITGVTAED VQKATLSLVD IQEKLRPFLS AGAILIDHPI VIDTSLVFKY PNSRKLRRPS
LNTLCMSVLG YEVQKAGVSH HCVHDAAAAM KLALAVIKKR VDTTITLTKE AEKSRLFLHR
IPHHLSSEEL KKDLALKFFP KNFTIDVKPA KTQGGYYCAV VIFGSSVEAN QAFENVNGYK
ETDSSGLPQK LISCSISTFY VR