ID   SDPA_BACSU              Reviewed;         158 AA.
AC   O34889;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Sporulation-delaying protein SdpA;
GN   Name=sdpA {ECO:0000303|PubMed:12817086}; Synonyms=yvaW;
GN   OrderedLocusNames=BSU33750;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RA   Nakamura A., Grau R., Perego M., Hoch J.A.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   REQUIRED FOR SDPC ACTIVITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / PY79;
RX   PubMed=12817086; DOI=10.1126/science.1086462;
RA   Gonzalez-Pastor J.E., Hobbs E.C., Losick R.;
RT   "Cannibalism by sporulating bacteria.";
RL   Science 301:510-513(2003).
RN   [4]
RP   REPRESSION BY ABRB AND ABH.
RX   PubMed=17720793; DOI=10.1128/jb.01081-07;
RA   Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.;
RT   "Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.";
RL   J. Bacteriol. 189:7720-7732(2007).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=168 / PY79;
RX   PubMed=23687264; DOI=10.1128/jb.00407-13;
RA   Perez Morales T.G., Ho T.D., Liu W.T., Dorrestein P.C., Ellermeier C.D.;
RT   "Production of the cannibalism toxin SDP is a multistep process that
RT   requires SdpA and SdpB.";
RL   J. Bacteriol. 195:3244-3251(2013).
CC   -!- FUNCTION: Required for the maturation of SdpC to SDP (PubMed:12817086).
CC       Not required for SdpC signal peptide cleavage, secretion from the cell
CC       or disulfide bond formation (PubMed:23687264).
CC       {ECO:0000269|PubMed:12817086, ECO:0000269|PubMed:23687264}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23687264}. Note=A
CC       small amount may be associated with the cell membrane
CC       (PubMed:23687264).
CC   -!- INDUCTION: By Spo0A during nutrient starvation (PubMed:12817086).
CC       Repressed by AbrB during regular growth when nutrients are plentiful,
CC       in association with the transcriptional repressor Abh
CC       (PubMed:17720793). {ECO:0000269|PubMed:12817086,
CC       ECO:0000269|PubMed:17720793}.
CC   -!- DISRUPTION PHENOTYPE: When the sdpA-sdpB-sdpC operon is deleted,
CC       increased rate of spore formation; a double operon deletion (sdpA-sdpC
CC       plus skfA-skfH) makes spores even faster (PubMed:12817086). A single
CC       deletion mutant does not have SDP activity (active peptide of sdpC)
CC       (PubMed:23687264). {ECO:0000269|PubMed:12817086,
CC       ECO:0000269|PubMed:23687264}.
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DR   EMBL; AB006738; BAA21900.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15380.1; -; Genomic_DNA.
DR   PIR; H70028; H70028.
DR   RefSeq; NP_391255.1; NC_000964.3.
DR   RefSeq; WP_009968174.1; NZ_JNCM01000033.1.
DR   AlphaFoldDB; O34889; -.
DR   SMR; O34889; -.
DR   STRING; 224308.BSU33750; -.
DR   TCDB; 9.A.31.1.1; the putative sdpab peptide antibiotic-like killing factor exporter (sdpab) family.
DR   PaxDb; O34889; -.
DR   EnsemblBacteria; CAB15380; CAB15380; BSU_33750.
DR   GeneID; 938629; -.
DR   KEGG; bsu:BSU33750; -.
DR   PATRIC; fig|224308.179.peg.3660; -.
DR   BioCyc; BSUB:BSU33750-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030152; P:bacteriocin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR023902; Sporulation_SdpA.
DR   Pfam; PF17418; SdpA; 1.
DR   TIGRFAMs; TIGR04034; export_SdpA; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic biosynthesis; Bacteriocin biosynthesis; Cytoplasm;
KW   Reference proteome.
FT   CHAIN           1..158
FT                   /note="Sporulation-delaying protein SdpA"
FT                   /id="PRO_0000049936"
SQ   SEQUENCE   158 AA;  18651 MW;  C495D20D39CF46C7 CRC64;
     MTICFLLFSS YYFSNISPQN PLFKKNFLQQ LSPQGFGFYS KSPTEENISF HTKENLKLPN
     ALPNNFFGIK REGRVQAIEL GKIVENIDPK NWKTCENNNS CTNLEKQIKP IKVIKNEDYI
     HLSKGEYLIY RQKPLSWYWI DFKQTTSFER KVLKIKIV