SDPR_BACSU
ID SDPR_BACSU Reviewed; 90 AA.
AC O32242;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcriptional repressor SdpR;
GN Name=sdpR; Synonyms=yvbA; OrderedLocusNames=BSU33790;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=168 / PY79;
RX PubMed=16469701; DOI=10.1016/j.cell.2005.11.041;
RA Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.;
RT "A three-protein signaling pathway governing immunity to a bacterial
RT cannibalism toxin.";
RL Cell 124:549-559(2006).
RN [3]
RP INDUCTION.
RC STRAIN=168 / PY79;
RX PubMed=23687264; DOI=10.1128/jb.00407-13;
RA Perez Morales T.G., Ho T.D., Liu W.T., Dorrestein P.C., Ellermeier C.D.;
RT "Production of the cannibalism toxin SDP is a multistep process that
RT requires SdpA and SdpB.";
RL J. Bacteriol. 195:3244-3251(2013).
CC -!- FUNCTION: Represses the transcription of the sdpIR operon and of
CC several other operons that probably contribute to delaying commitment
CC to sporulation. {ECO:0000269|PubMed:16469701}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16469701}.
CC Note=Sequestred at the bacterial membrane by SdpC-bound SdpI.
CC -!- INDUCTION: By Spo0A during nutrient starvation through its direct
CC negative control of AbrB, repressed by AbrB during regular growth when
CC nutrients are plentiful (PubMed:16469701). Represses its own
CC transcription (PubMed:16469701). Induced by expression of SDP (active
CC peptide of sdpC) (PubMed:16469701, PubMed:23687264).
CC {ECO:0000269|PubMed:16469701}.
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DR EMBL; AL009126; CAB15384.1; -; Genomic_DNA.
DR PIR; D70029; D70029.
DR RefSeq; NP_391259.1; NC_000964.3.
DR RefSeq; WP_003243541.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O32242; -.
DR SMR; O32242; -.
DR STRING; 224308.BSU33790; -.
DR PaxDb; O32242; -.
DR PRIDE; O32242; -.
DR EnsemblBacteria; CAB15384; CAB15384; BSU_33790.
DR GeneID; 936249; -.
DR KEGG; bsu:BSU33790; -.
DR PATRIC; fig|224308.179.peg.3664; -.
DR eggNOG; COG0640; Bacteria.
DR InParanoid; O32242; -.
DR OMA; MNLRRDV; -.
DR PhylomeDB; O32242; -.
DR BioCyc; BSUB:BSU33790-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01022; HTH_5; 1.
DR PRINTS; PR00778; HTHARSR.
DR SMART; SM00418; HTH_ARSR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50987; HTH_ARSR_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..90
FT /note="Transcriptional repressor SdpR"
FT /id="PRO_0000312745"
FT DOMAIN 1..87
FT /note="HTH arsR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT DNA_BIND 39..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ SEQUENCE 90 AA; 10243 MW; E2008BDD17975113 CRC64;
MNNVFKAISD PTRRKILDLL KGGDMTAGDI AEHFNISKPS ISHHLNILKQ AEVISDHRKG
QFIYYSLNTT VLQDSINWML NFINKGDNDL
