ID   SDR2A_ARATH             Reviewed;         303 AA.
AC   Q9SCU0;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Short-chain dehydrogenase reductase 2a;
DE            Short=AtSDR2a;
DE            EC=1.1.1.-;
GN   Name=SDR2a; Synonyms=SDR2; OrderedLocusNames=At3g51680; ORFNames=T18N14.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12417697; DOI=10.1105/tpc.006494;
RA   Cheng W.-H., Endo A., Zhou L., Penney J., Chen H.-C., Arroyo A., Leon P.,
RA   Nambara E., Asami T., Seo M., Koshiba T., Sheen J.;
RT   "A unique short-chain dehydrogenase/reductase in Arabidopsis glucose
RT   signaling and abscisic acid biosynthesis and functions.";
RL   Plant Cell 14:2723-2743(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL132968; CAB63154.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78826.1; -; Genomic_DNA.
DR   PIR; T46064; T46064.
DR   RefSeq; NP_190736.1; NM_115027.2.
DR   AlphaFoldDB; Q9SCU0; -.
DR   SMR; Q9SCU0; -.
DR   STRING; 3702.AT3G51680.1; -.
DR   iPTMnet; Q9SCU0; -.
DR   PaxDb; Q9SCU0; -.
DR   PRIDE; Q9SCU0; -.
DR   EnsemblPlants; AT3G51680.1; AT3G51680.1; AT3G51680.
DR   GeneID; 824331; -.
DR   Gramene; AT3G51680.1; AT3G51680.1; AT3G51680.
DR   KEGG; ath:AT3G51680; -.
DR   Araport; AT3G51680; -.
DR   TAIR; locus:2098287; AT3G51680.
DR   eggNOG; KOG0725; Eukaryota.
DR   HOGENOM; CLU_010194_1_0_1; -.
DR   InParanoid; Q9SCU0; -.
DR   OMA; QANLMTI; -.
DR   OrthoDB; 1373099at2759; -.
DR   PhylomeDB; Q9SCU0; -.
DR   BioCyc; ARA:AT3G51680-MON; -.
DR   BRENDA; 1.1.1.288; 399.
DR   PRO; PR:Q9SCU0; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SCU0; baseline and differential.
DR   Genevisible; Q9SCU0; AT.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Short-chain dehydrogenase reductase 2a"
FT                   /id="PRO_0000419510"
FT   ACT_SITE        190
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         38..62
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         177
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  32151 MW;  DC1BD28DABE38DD6 CRC64;
     MPAQVIAEQT TFHSVHDTIM EETNTTLYPK RLEGKVAIIT GGAHGIGKAT VMLFARHGAT
     VVIADVDNVA GSSLAKSLSS HKTSPMVAFI SCDVSVEADV ENLVNVTVAR YGRLDILFNN
     AGVLGDQKKH KSILDFDADE FDHVMRVNVR GVGLGMKHGA RAMIKRGFKG CIISTASVAG
     VMGGMGPHAY TASKHAIVGL TKNAACELGK YGIRVNCISP FGVATSMLVN AWRKTSGGDV
     EDDDVEEMEE FVRSLANLKG ETLRANDIAE AALYLASDES KYVNGHNLVV DGGVTTARNC
     VGL