SDR4_ARATH
ID SDR4_ARATH Reviewed; 298 AA.
AC F4J2Z7; F4J2Z8; Q0WSL8; Q84W02; Q9LS70;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Short-chain dehydrogenase reductase 4;
DE Short=AtSDR4;
DE EC=1.1.1.-;
GN Name=SDR4; OrderedLocusNames=At3g29250; ORFNames=MXO21.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-298 (ISOFORMS 1/2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 150-298 (ISOFORMS 1/2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12417697; DOI=10.1105/tpc.006494;
RA Cheng W.-H., Endo A., Zhou L., Penney J., Chen H.-C., Arroyo A., Leon P.,
RA Nambara E., Asami T., Seo M., Koshiba T., Sheen J.;
RT "A unique short-chain dehydrogenase/reductase in Arabidopsis glucose
RT signaling and abscisic acid biosynthesis and functions.";
RL Plant Cell 14:2723-2743(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4J2Z7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4J2Z7-2; Sequence=VSP_044207;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE77557.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB026657; BAB01821.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77556.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77557.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; ANM64100.1; -; Genomic_DNA.
DR EMBL; AK227910; BAE99880.1; -; mRNA.
DR EMBL; BT004580; AAO42826.1; -; mRNA.
DR RefSeq; NP_001118737.1; NM_001125265.2.
DR RefSeq; NP_001326150.1; NM_001339015.1. [F4J2Z7-2]
DR RefSeq; NP_189570.3; NM_113849.3. [F4J2Z7-1]
DR AlphaFoldDB; F4J2Z7; -.
DR SMR; F4J2Z7; -.
DR BioGRID; 7909; 3.
DR STRING; 3702.AT3G29250.1; -.
DR PaxDb; F4J2Z7; -.
DR PRIDE; F4J2Z7; -.
DR ProteomicsDB; 234481; -. [F4J2Z7-1]
DR EnsemblPlants; AT3G29250.1; AT3G29250.1; AT3G29250. [F4J2Z7-1]
DR EnsemblPlants; AT3G29250.3; AT3G29250.3; AT3G29250. [F4J2Z7-2]
DR GeneID; 822580; -.
DR Gramene; AT3G29250.1; AT3G29250.1; AT3G29250. [F4J2Z7-1]
DR Gramene; AT3G29250.3; AT3G29250.3; AT3G29250. [F4J2Z7-2]
DR KEGG; ath:AT3G29250; -.
DR Araport; AT3G29250; -.
DR TAIR; locus:2094807; AT3G29250.
DR eggNOG; KOG0725; Eukaryota.
DR InParanoid; F4J2Z7; -.
DR OrthoDB; 1074094at2759; -.
DR PRO; PR:F4J2Z7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J2Z7; baseline and differential.
DR Genevisible; F4J2Z7; AT.
DR GO; GO:0005507; F:copper ion binding; HDA:TAIR.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Oxidoreductase; Reference proteome.
FT CHAIN 1..298
FT /note="Short-chain dehydrogenase reductase 4"
FT /id="PRO_0000419514"
FT ACT_SITE 195
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 50..74
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 182
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VAR_SEQ 42..43
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044207"
SQ SEQUENCE 298 AA; 31803 MW; 61F1479C1D3B76DF CRC64;
MPKLLVIFNI IYPLQSLKKD TFNFWWSFQK WKYNKTMSGL RQVLDGKIAI ITGGASGIGA
EAVRLFTDHG AKVVIVDIQE ELGQNLAVSI GLDKASFYRC NVTDETDVEN AVKFTVEKHG
KLDVLFSNAG VLEAFGSVLD LDLEAFDRTM AVNVRGAAAF IKHAARSMVA SGTRGSIVCT
TSIAAEIGGP GPHSYTASKH ALLGLIRSAC AGLGQYGIRV NGVAPYGVAT GMTSAYNEEA
VKMLEEYGEA LGNLKGVVLK ARHIAEAALF LASDDSVYIS GQNLVVDGGF SVVKLMTT
