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SDRD_STAA8
ID   SDRD_STAA8              Reviewed;        1349 AA.
AC   Q2G0L4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Serine-aspartate repeat-containing protein D;
DE   Flags: Precursor;
GN   Name=sdrD; OrderedLocusNames=SAOUHSC_00545;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   SUBCELLULAR LOCATION, AND PROCESSING BY SORTASE A.
RC   STRAIN=RN4220;
RX   PubMed=11830639; DOI=10.1073/pnas.032523999;
RA   Mazmanian S.K., Ton-That H., Su K., Schneewind O.;
RT   "An iron-regulated sortase anchors a class of surface protein during
RT   Staphylococcus aureus pathogenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2293-2298(2002).
RN   [3]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=RN4220;
RX   PubMed=18800056; DOI=10.1038/emboj.2008.185;
RA   DeDent A., Bae T., Missiakas D.M., Schneewind O.;
RT   "Signal peptides direct surface proteins to two distinct envelope locations
RT   of Staphylococcus aureus.";
RL   EMBO J. 27:2656-2668(2008).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROSCOPY, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=RN4220;
RX   PubMed=20472795; DOI=10.1128/jb.01452-09;
RA   Sibbald M.J., Winter T., van der Kooi-Pol M.M., Buist G., Tsompanidou E.,
RA   Bosma T., Schafer T., Ohlsen K., Hecker M., Antelmann H., Engelmann S.,
RA   van Dijl J.M.;
RT   "Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 192:3788-3800(2010).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH HOST DSG1.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=26924733; DOI=10.1038/srep22134;
RA   Askarian F., Ajayi C., Hanssen A.M., van Sorge N.M., Pettersen I.,
RA   Diep D.B., Sollid J.U., Johannessen M.;
RT   "The interaction between Staphylococcus aureus SdrD and desmoglein 1 is
RT   important for adhesion to host cells.";
RL   Sci. Rep. 6:22134-22134(2016).
RN   [6]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=NCTC 8325 / PS 47;
RX   PubMed=27795358; DOI=10.1128/iai.00559-16;
RA   Askarian F., Uchiyama S., Valderrama J.A., Ajayi C., Sollid J.U.E.,
RA   van Sorge N.M., Nizet V., van Strijp J.A.G., Johannessen M.;
RT   "Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus
RT   Virulence and Survival in Blood.";
RL   Infect. Immun. 85:0-0(2017).
CC   -!- FUNCTION: Cell surface-associated calcium-binding protein which plays
CC       an important role in adhesion and pathogenesis (PubMed:26924733).
CC       Mediates interactions with components of the extracellular matrix such
CC       as host DSG1 to promote bacterial adhesion to host cells
CC       (PubMed:26924733). Contributes to the resistance to killing by innate
CC       immune components such as neutrophils present in blood and thus
CC       attenuates bacterial clearance (PubMed:27795358).
CC       {ECO:0000269|PubMed:26924733, ECO:0000269|PubMed:27795358}.
CC   -!- SUBUNIT: Interacts with host DSG1; this interaction increases S. aureus
CC       adherence to keratinocytes. {ECO:0000269|PubMed:26924733}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477, ECO:0000269|PubMed:18800056,
CC       ECO:0000269|PubMed:20472795, ECO:0000305|PubMed:11830639};
CC       Peptidoglycan-anchor {ECO:0000255|PROSITE-ProRule:PRU00477,
CC       ECO:0000269|PubMed:20472795, ECO:0000305|PubMed:11830639}. Note=Found
CC       in a ring-like distribution on the cell surface (PubMed:18800056).
CC       Colocalizes with ClfB (PubMed:18800056). Anchored to the cell wall by
CC       sortase A (Probable). {ECO:0000269|PubMed:18800056,
CC       ECO:0000305|PubMed:11830639}.
CC   -!- INDUCTION: Less protein is secreted in a secG mutant (at protein
CC       level). {ECO:0000269|PubMed:20472795}.
CC   -!- DISRUPTION PHENOTYPE: About 3.5-fold reduction of survival rate in
CC       human blood and about 2-fold reduction in mouse blood.
CC       {ECO:0000269|PubMed:27795358}.
CC   -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC       (SDr) family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29693.1; -; Genomic_DNA.
DR   RefSeq; WP_000934431.1; NZ_LS483365.1.
DR   RefSeq; YP_499118.1; NC_007795.1.
DR   AlphaFoldDB; Q2G0L4; -.
DR   SMR; Q2G0L4; -.
DR   STRING; 1280.SAXN108_0618; -.
DR   EnsemblBacteria; ABD29693; ABD29693; SAOUHSC_00545.
DR   GeneID; 3920825; -.
DR   KEGG; sao:SAOUHSC_00545; -.
DR   PATRIC; fig|93061.5.peg.491; -.
DR   eggNOG; COG4932; Bacteria.
DR   HOGENOM; CLU_004137_0_1_9; -.
DR   OMA; NKTAMTR; -.
DR   PRO; PR:Q2G0L4; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 5.
DR   Gene3D; 2.60.40.1280; -; 1.
DR   InterPro; IPR011266; Adhesin_Fg-bd_dom_2.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR011252; Fibrogen-bd_dom1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR033764; Sdr_B.
DR   InterPro; IPR041171; SDR_Ig.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   Pfam; PF17961; Big_8; 1.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF17210; SdrD_B; 5.
DR   Pfam; PF10425; SdrG_C_C; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49401; SSF49401; 2.
DR   TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   Calcium; Cell wall; Peptidoglycan-anchor; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..1315
FT                   /note="Serine-aspartate repeat-containing protein D"
FT                   /id="PRO_0000281204"
FT   PROPEP          1316..1349
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477,
FT                   ECO:0000305|PubMed:11830639"
FT                   /id="PRO_0000281205"
FT   DOMAIN          569..680
FT                   /note="CNA-B 1"
FT   DOMAIN          681..791
FT                   /note="CNA-B 2"
FT   DOMAIN          792..901
FT                   /note="CNA-B 3"
FT   DOMAIN          902..1012
FT                   /note="CNA-B 4"
FT   DOMAIN          1013..1123
FT                   /note="CNA-B 5"
FT   REGION          36..568
FT                   /note="Ligand binding A region"
FT   REGION          54..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          856..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          972..992
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1081..1325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           23..34
FT                   /note="YSIRK-G/S signaling motif"
FT                   /evidence="ECO:0000305|PubMed:18800056"
FT   MOTIF           1312..1316
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        54..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1091..1116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1117..1284
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1285..1312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1315
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   1349 AA;  146087 MW;  B551763296A2C432 CRC64;
     MLNRENKTAI TRKGMVSNRL NKFSIRKYTV GTASILVGTT LIFGLGNQEA KAAESTNKEL
     NEATTSASDN QSSDKVDMQQ LNQEDNTKND NQKEMVSSQG NETTSNGNKL IEKESVQSTT
     GNKVEVSTAK SDEQASPKST NEDLNTKQTI SNQEALQPDL QENKSVVNVQ PTNEENKKVD
     AKTESTTLNV KSDAIKSNDE TLVDNNSNSN NENNADIILP KSTAPKRLNT RMRIAAVQPS
     STEAKNVNDL ITSNTTLTVV DADKNNKIVP AQDYLSLKSQ ITVDDKVKSG DYFTIKYSDT
     VQVYGLNPED IKNIGDIKDP NNGETIATAK HDTANNLITY TFTDYVDRFN SVQMGINYSI
     YMDADTIPVS KNDVEFNVTI GNTTTKTTAN IQYPDYVVNE KNSIGSAFTE TVSHVGNKEN
     PGYYKQTIYV NPSENSLTNA KLKVQAYHSS YPNNIGQINK DVTDIKIYQV PKGYTLNKGY
     DVNTKELTDV TNQYLQKITY GDNNSAVIDF GNADSAYVVM VNTKFQYTNS ESPTLVQMAT
     LSSTGNKSVS TGNALGFTNN QSGGAGQEVY KIGNYVWEDT NKNGVQELGE KGVGNVTVTV
     FDNNTNTKVG EAVTKEDGSY LIPNLPNGDY RVEFSNLPKG YEVTPSKQGN NEELDSNGLS
     SVITVNGKDN LSADLGIYKP KYNLGDYVWE DTNKNGIQDQ DEKGISGVTV TLKDENGNVL
     KTVTTDADGK YKFTDLDNGN YKVEFTTPEG YTPTTVTSGS DIEKDSNGLT TTGVINGADN
     MTLDSGFYKT PKYNLGNYVW EDTNKDGKQD STEKGISGVT VTLKNENGEV LQTTKTDKDG
     KYQFTGLENG TYKVEFETPS GYTPTQVGSG TDEGIDSNGT STTGVIKDKD NDTIDSGFYK
     PTYNLGDYVW EDTNKNGVQD KDEKGISGVT VTLKDENDKV LKTVTTDENG KYQFTDLNNG
     TYKVEFETPS GYTPTSVTSG NDTEKDSNGL TTTGVIKDAD NMTLDSGFYK TPKYSLGDYV
     WYDSNKDGKQ DSTEKGIKDV KVTLLNEKGE VIGTTKTDEN GKYCFDNLDS GKYKVIFEKP
     AGLTQTVTNT TEDDKDADGG EVDVTITDHD DFTLDNGYFE EDTSDSDSDS DSDSDSDSDS
     DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS
     DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS DSDSDSDSDS
     DSDSDSDSDS DSDSDSDSDS DSDSDSDSDA GKHTPVKPMS TTKDHHNKAK ALPETGSENN
     GSNNATLFGG LFAALGSLLL FGRRKKQNK
 
 
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