SDRI_STASA
ID SDRI_STASA Reviewed; 1893 AA.
AC Q8KWM1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Serine-aspartate repeat-containing protein I;
DE Flags: Precursor;
GN Name=sdrI;
OS Staphylococcus saprophyticus.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=29385;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN COLLAGEN BINDING.
RC STRAIN=7108;
RX PubMed=16861649; DOI=10.1128/iai.01885-05;
RA Sakinc T., Kleine B., Gatermann S.G.;
RT "SdrI, a serine-aspartate repeat protein identified in Staphylococcus
RT saprophyticus strain 7108, is a collagen-binding protein.";
RL Infect. Immun. 74:4615-4623(2006).
CC -!- FUNCTION: Responsible for collagen binding by S.saprophyticus.
CC {ECO:0000269|PubMed:16861649}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
CC -!- DOMAIN: The amino acid composition of the SD repeat region is different
CC from that of other SD repeats, containing a very high percentage of
CC alanine residues.
CC -!- DOMAIN: The ligand binding A region is specifically involved in
CC collagen binding.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC (SDr) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF402316; AAM90673.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8KWM1; -.
DR SMR; Q8KWM1; -.
DR PRIDE; Q8KWM1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 2.60.40.1280; -; 1.
DR InterPro; IPR011266; Adhesin_Fg-bd_dom_2.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR033764; Sdr_B.
DR InterPro; IPR041171; SDR_Ig.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR Pfam; PF17961; Big_8; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17210; SdrD_B; 2.
DR Pfam; PF10425; SdrG_C_C; 1.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SUPFAM; SSF49401; SSF49401; 2.
DR TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 1: Evidence at protein level;
KW Cell wall; Peptidoglycan-anchor; Repeat; Secreted; Signal.
FT SIGNAL 1..54
FT /evidence="ECO:0000255"
FT CHAIN 55..1857
FT /note="Serine-aspartate repeat-containing protein I"
FT /id="PRO_0000305379"
FT PROPEP 1858..1893
FT /note="Removed by sortase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000305380"
FT REPEAT 72..83
FT /note="1"
FT REPEAT 84..95
FT /note="2"
FT REPEAT 96..107
FT /note="3"
FT REPEAT 108..119
FT /note="4"
FT REPEAT 120..131
FT /note="5"
FT REPEAT 132..143
FT /note="6"
FT REPEAT 144..155
FT /note="7"
FT REPEAT 156..167
FT /note="8"
FT REPEAT 168..179
FT /note="9"
FT REPEAT 180..191
FT /note="10"
FT REPEAT 192..203
FT /note="11"
FT REPEAT 204..215
FT /note="12"
FT REPEAT 216..227
FT /note="13"
FT REPEAT 228..239
FT /note="14"
FT REPEAT 240..251
FT /note="15"
FT REPEAT 252..263
FT /note="16"
FT REPEAT 264..275
FT /note="17"
FT REPEAT 276..287
FT /note="18"
FT REPEAT 288..299
FT /note="19"
FT REPEAT 300..311
FT /note="20"
FT REPEAT 312..323
FT /note="21"
FT DOMAIN 756..874
FT /note="CNA-B 1"
FT DOMAIN 875..984
FT /note="CNA-B 2"
FT REGION 53..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..323
FT /note="21 X 12 AA tandem repeat of [AP]-[AE]-T-K-E-[EK]-A-
FT [AV]-[IT]-[AST]-E-E"
FT REGION 324..755
FT /note="Ligand binding A region"
FT REGION 941..1867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1854..1858
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT COMPBIAS 56..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1834
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1857
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ SEQUENCE 1893 AA; 195068 MW; 29EA31776AEB34DD CRC64;
MNFKGVKLLK NSKKRLDFLP NTLNKYSIRK FTVGTASILV GATLFLGVSN EAEAAEKIDS
PTKEKVATTE EAATKEEAAT TEEPATKEEA ATTEEPATKE EAAIAEEPAT KEEAATTEEP
ATKEEAAIAE EPATKEEAAT TEEPATKEEA ATTEEPATKE EAAIAEEPAT KEEAATTEEP
ATKEEAAIAE EPATKEEAVT SEEAATKEKA AIAEEPATKE EAAIAEEPET KEEAATTEEP
ATKEEAAIAE EAATKEKAVT SEEAATKEKA AIAEEAATKE KAAIAEEPET KEEAATTEEP
ETKEEAAIAE EPATKEKAVT SEEAHGINNK NKQLLDMDKN STIDEKFDYA KQAINELNIN
QKDISNIEAS IKNNSDLKNL SKEELNNEIL RAALVNESNN NDYGLQTLSA IEPLTTNVRN
KNNSLSPVSR LKMLATATSG QNVNDKINIT NASLTLNQKN NQHDDNTVWP TSNEQLRLSA
DYELDNSIKE GDTFTIKYGD YIRPGALELP AKNTQLRSKE GSIVANGVYD ENTTTTTYTF
TNYVDQYQNI TGSFNLLATP KRETVTTDKQ TYPMNVTIAN QEVSENFVVD YGNHEDHLTN
AAVVNVDNVN NQHNEVVYLN QSGDRIYDAK YFSIVQNGTF IPNEVKVYEV LDDNVLVDSF
NPDLNGPAVK DVTSEFTPQY SLNNTRVDID LNRSNMNKGS RYIITQAVKP SGTGNVNTTY
ELTRYGNEAS RYPTGTKSTT VSYINGSSTA QGDNPTYNLG DYVWLDKNKD GIQNDDEKGI
SGVYVILKDS NNKELQRATT DDTGRYQFNN LQNGTYNVEF VIPNNYTPSP SNTIDNDTID
SDGQKDGDSN VVVAKGTINN ADNMTVDTGF YETPKYSLGD YVWKDTNKDG VQDSDEKGIQ
GVTVTLKDKN GNVLKTTTTD ENGSYRFDNL DSGDYIVHFE KPEGLTQTTT NSDSDENKDA
DGEEVHVTIT DHDDFSIDNG YFDEDSDADA DSDADADSDA DADADADSDA DADADADSDA
DSDADADADS DADADADADA DSDSDADADA DADADSDADA DADSDADADA DADSDADADA
DSDADSDADA DADSDADADA DADADSDADA DSDADADADA DADSDADADA DADSDADADS
DSDADADADA DSDADADADA DSDADADADS DADADADSDA DADADSDADS DADADADSDA
DADADADADS DADADADSDA DADADADADS DADSDADSDA DSDADADADS DADADADADA
DSDADADSDA DADSDADADA DADADSDADA DSDADADSDA DADSDADADA DADSDADADA
DADSDADADA DSDSDADADA DADSDADADA DADSDADADS DADADSDADA DADADSDADA
DSDADADADA DSDADADADS DADADADADS DADADSDADA DADADADSDA DADADADSDA
DADADADADA DSDADADADS DADADADSDA DSDADADADS DADADADADS DADADSDADA
DSDADADSDA DADADADSDA DADSDADADS DADADADADS DADADSDADA DADSDADADA
DSDADADSDA DADADADADS DADADSDADS DADADADSDS DADADADADS DADADADADS
DADADSDADA DADSDSDADA DADADSDADA DSDADADADA DSDADADADS DADADADSDA
DADADSDADS DADADADSDA DADADADSDA DADSDADADA DADSDADADS DADADADADS
DADADSDADA DSDADADSDA DADSDADADS DADADADADS DADADSDADA DADADSDADA
DADSDADADA DSDADADADS DADADADSDA DADADSDADK YHNDTADKSN DNELPDTGNN
TQNNGTLFGS LFAALGGLFL VGSRRKNKNN EEK
