ID   SDS23_KLULA             Reviewed;         518 AA.
AC   Q6CUE1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein SDS23;
GN   Name=SDS23; OrderedLocusNames=KLLA0C05588g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in DNA replication and cell separation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SDS23 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01299.1; -; Genomic_DNA.
DR   RefSeq; XP_452448.1; XM_452448.1.
DR   AlphaFoldDB; Q6CUE1; -.
DR   SMR; Q6CUE1; -.
DR   STRING; 28985.XP_452448.1; -.
DR   EnsemblFungi; CAH01299; CAH01299; KLLA0_C05588g.
DR   GeneID; 2892397; -.
DR   KEGG; kla:KLLA0_C05588g; -.
DR   eggNOG; KOG1764; Eukaryota.
DR   HOGENOM; CLU_024459_1_1_1; -.
DR   InParanoid; Q6CUE1; -.
DR   OMA; GMFDYRD; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042149; P:cellular response to glucose starvation; IEA:InterPro.
DR   GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR   Gene3D; 3.10.580.10; -; 2.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR016711; Ssd23.
DR   Pfam; PF00571; CBS; 2.
DR   PIRSF; PIRSF018148; UCP018148_CBS_YBR214w; 1.
DR   SMART; SM00116; CBS; 3.
DR   SUPFAM; SSF54631; SSF54631; 2.
DR   PROSITE; PS51371; CBS; 4.
PE   3: Inferred from homology;
KW   CBS domain; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..518
FT                   /note="Protein SDS23"
FT                   /id="PRO_0000324953"
FT   DOMAIN          181..242
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          265..323
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          350..409
FT                   /note="CBS 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          429..501
FT                   /note="CBS 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          77..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  56011 MW;  096DFEB62825070C CRC64;
     MQSSGSSASS SRHVSIVELL STPPNAGVPS NSAAPSSSSR VAAQAQVQSQ SQSPKLSATA
     AAAAAATADN FGNGNSNFGQ AGAGTPAGSH IHHGSDAESI SSISSASTTS MHCPLERTGS
     GTGSGYVPGP NSDVPISPSL SAVDTLHSHS VSRTNSESSF DTQLSRIHTT KWQLIPLSQL
     VEQNKLIFID GSISVEEAFN TLVKYNLTSL PVENSPDDID CLTFDYNDLN SYLLLVLNKI
     TVNNPEVTRQ CQLGHPVPVG EIIKLTPKNP FYKLPEQENL STAMMILGSG VHRVAITNQE
     NTKITGILSQ RRLIKYLWDN ARSFQNFEHL FQKSLKDLKI GVLDTHTKPT SRQSRVISIQ
     GDELLIMALF KMHTERISSI AVIDPQGNLL GNISVTDVKH ITRTSQYPLL QNTCLHFISV
     ILDKRGIEMG KDSFPIFHVY PTSSLARTIA KLVATKAHRL WIVQPSGDTP VDSEKDKRSG
     KLIGVVSLTD ILGLLARHQT EFKRVDPLAA RRQRGSIV