SDS24_CANAL
ID SDS24_CANAL Reviewed; 628 AA.
AC Q5A744; A0A1D8PEA1; O94035;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Protein SDS23;
GN Name=SDS24; Synonyms=SDS23; OrderedLocusNames=CAALFM_C108370WA;
GN ORFNames=Ca41C10.01c, CaO19.12584, CaO19.5118;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1161;
RA Oliver K., Harris D., Barrell B.G., Rajandream M.A.;
RT "Candida albicans strain 1161 genome pilot sequencing project.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [5]
RP INDUCTION BY FLUCONAZOLE.
RX PubMed=15820985; DOI=10.1093/jac/dki088;
RA Copping V.M.S., Barelle C.J., Hube B., Gow N.A.R., Brown A.J.P., Odds F.C.;
RT "Exposure of Candida albicans to antifungal agents affects expression of
RT SAP2 and SAP9 secreted proteinase genes.";
RL J. Antimicrob. Chemother. 55:645-654(2005).
CC -!- FUNCTION: Involved in DNA replication and cell separation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- INDUCTION: By the antifungal drug fluconazole.
CC {ECO:0000269|PubMed:15820985}.
CC -!- SIMILARITY: Belongs to the SDS23 family. {ECO:0000305}.
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DR EMBL; AL033501; CAA21985.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26475.1; -; Genomic_DNA.
DR RefSeq; XP_717654.2; XM_712561.2.
DR AlphaFoldDB; Q5A744; -.
DR SMR; Q5A744; -.
DR BioGRID; 1223850; 1.
DR STRING; 237561.Q5A744; -.
DR PRIDE; Q5A744; -.
DR GeneID; 3640756; -.
DR KEGG; cal:CAALFM_C108370WA; -.
DR CGD; CAL0000184899; SDS24.
DR VEuPathDB; FungiDB:C1_08370W_A; -.
DR eggNOG; KOG1764; Eukaryota.
DR HOGENOM; CLU_024459_1_0_1; -.
DR InParanoid; Q5A744; -.
DR OrthoDB; 1471847at2759; -.
DR PRO; PR:Q5A744; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031588; C:nucleotide-activated protein kinase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016208; F:AMP binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0042149; P:cellular response to glucose starvation; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0050790; P:regulation of catalytic activity; IBA:GO_Central.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR016711; Ssd23.
DR Pfam; PF00571; CBS; 2.
DR PIRSF; PIRSF018148; UCP018148_CBS_YBR214w; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; SSF54631; 2.
DR PROSITE; PS51371; CBS; 2.
PE 2: Evidence at transcript level;
KW CBS domain; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..628
FT /note="Protein SDS23"
FT /id="PRO_0000324949"
FT DOMAIN 258..319
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 334..392
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 174
FT /note="N -> Y (in Ref. 1; CAA21985)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="A -> AA (in Ref. 1; CAA21985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 628 AA; 67545 MW; 4ABA432FC1661628 CRC64;
MVNPPQPRQM PKSPRLSTST SSGPSAVPNL LGSPRPSPPQ LQHQPSSAST SSTTSTATTG
GSISATAPGS TQHYLHHHPS RKTSIVEILS SPPPLPTDPN DPIHQLSLSR HASTSSNKSS
SQSIAPGSTA ITNHAFSLVD WSEIPLTELT ESNKLISIHS SHSVQSAFET LLKNNLTSVP
VSISKSDPHD LTNCLTFDYS DLNTYLLLIM NKINYSELNV DDIGDPNISP QERHEFVTQT
ISKAKRGEEV PVEFIIKLHP KNPFIKFNET DTLFSVMETL GNGVHRIAIT NEEGNKITGI
LSQRRLIKYM WENARRFPSL DFYLTSTLQD LKIGSSNPIT IYEDQMLIEA LHKMFNERVS
SLAVIDRSRT LIGNISIVDV KNVTSSKNSH LLFKSVLNFI SYNLSQKGIE EGQDQFPIFH
VNNQTSLGRV IAKLVATQSH RLWIVDSSRQ ASSMSSASAS APNSGMNNGV TVGYPAPADS
SITDKAEEVE ASSMSSPQLN AAAAAAAAVA TGAPTTATSA QPDFSYTSGT GKLVGVVTLT
DILGLFATSK GRRTDPQAAR NQRRRSSTST TRSSIDSALS AEGILPSGSA IIGSSNAANT
GRRGSVEVSS DVFRKSYTKA QENAFSKE
