SDT1_YEAST
ID SDT1_YEAST Reviewed; 280 AA.
AC P53078; D6VVB1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Suppressor of disruption of TFIIS;
GN Name=SDT1; Synonyms=SSM1; OrderedLocusNames=YGL224C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10858443; DOI=10.1074/jbc.m910371199;
RA Shimoaraiso M., Nakanishi T., Kubo T., Natori S.;
RT "Transcription elongation factor S-II confers yeast resistance to 6-
RT azauracil by enhancing expression of the SSM1 gene.";
RL J. Biol. Chem. 275:29623-29627(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9290212;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT chromosome VII.";
RL Yeast 13:1077-1090(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- FUNCTION: Could be an enzyme that inactivates 6-azauracil by modifying
CC it.
CC -!- SIMILARITY: Belongs to the SSM1 family. {ECO:0000305}.
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DR EMBL; D26043; BAB13723.1; -; Genomic_DNA.
DR EMBL; Z72746; CAA96940.1; -; Genomic_DNA.
DR EMBL; AY692802; AAT92821.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07895.1; -; Genomic_DNA.
DR PIR; S64246; S64246.
DR RefSeq; NP_011291.1; NM_001181089.1.
DR PDB; 3NUQ; X-ray; 1.70 A; A=1-280.
DR PDB; 3ONN; X-ray; 1.87 A; A=26-280.
DR PDB; 3OPX; X-ray; 1.70 A; A=26-280.
DR PDBsum; 3NUQ; -.
DR PDBsum; 3ONN; -.
DR PDBsum; 3OPX; -.
DR AlphaFoldDB; P53078; -.
DR SMR; P53078; -.
DR BioGRID; 33035; 39.
DR STRING; 4932.YGL224C; -.
DR MaxQB; P53078; -.
DR PaxDb; P53078; -.
DR PRIDE; P53078; -.
DR DNASU; 852648; -.
DR EnsemblFungi; YGL224C_mRNA; YGL224C; YGL224C.
DR GeneID; 852648; -.
DR KEGG; sce:YGL224C; -.
DR SGD; S000003192; SDT1.
DR VEuPathDB; FungiDB:YGL224C; -.
DR eggNOG; KOG3109; Eukaryota.
DR GeneTree; ENSGT00940000176629; -.
DR HOGENOM; CLU_059493_0_0_1; -.
DR InParanoid; P53078; -.
DR OMA; LYPHHVN; -.
DR BioCyc; YEAST:G3O-30698-MON; -.
DR ChiTaRS; RPL1A; yeast.
DR EvolutionaryTrace; P53078; -.
DR PRO; PR:P53078; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53078; protein.
DR GO; GO:0008252; F:nucleotidase activity; IDA:SGD.
DR GO; GO:0009166; P:nucleotide catabolic process; IBA:GO_Central.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IMP:SGD.
DR CDD; cd02604; HAD_5NT; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR041492; HAD_2.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010237; Pyr-5-nucltdase.
DR Pfam; PF13419; HAD_2; 1.
DR SFLD; SFLDG01132; C1.5.3:_5'-Nucleotidase_Like; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
DR TIGRFAMs; TIGR01993; Pyr-5-nucltdase; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..280
FT /note="Suppressor of disruption of TFIIS"
FT /id="PRO_0000072213"
FT HELIX 6..29
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 57..60
FT /evidence="ECO:0007829|PDB:3NUQ"
FT TURN 63..65
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 71..87
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 93..106
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 108..116
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 122..129
FT /evidence="ECO:0007829|PDB:3NUQ"
FT TURN 130..132
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 135..137
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 143..154
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 155..157
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 159..164
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 169..178
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 186..189
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 205..215
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 220..222
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 223..228
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 230..239
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 242..247
FT /evidence="ECO:0007829|PDB:3NUQ"
FT STRAND 249..251
FT /evidence="ECO:0007829|PDB:3OPX"
FT HELIX 254..256
FT /evidence="ECO:0007829|PDB:3ONN"
FT STRAND 264..268
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 269..274
FT /evidence="ECO:0007829|PDB:3NUQ"
FT HELIX 277..279
FT /evidence="ECO:0007829|PDB:3NUQ"
SQ SEQUENCE 280 AA; 31969 MW; 680F66359CD57B8B CRC64;
MTVEYTASDL ATYQNEVNEQ IAKNKAHLES LTHPGSKVTF PIDQDISATP QNPNLKVFFF
DIDNCLYKSS TRIHDLMQQS ILRFFQTHLK LSPEDAHVLN NSYYKEYGLA IRGLVMFHKV
NALEYNRLVD DSLPLQDILK PDIPLRNMLL RLRQSGKIDK LWLFTNAYKN HAIRCLRLLG
IADLFDGLTY CDYSRTDTLV CKPHVKAFEK AMKESGLARY ENAYFIDDSG KNIETGIKLG
MKTCIHLVEN EVNEILGQTP EGAIVISDIL ELPHVVSDLF
