SDZ12_CAEEL
ID SDZ12_CAEEL Reviewed; 330 AA.
AC Q9BLC4;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein sdz-12 {ECO:0000305};
DE AltName: Full=Skn-1-dependent zygotic transcript 12 protein {ECO:0000312|WormBase:F12E12.5};
GN Name=sdz-12 {ECO:0000303|PubMed:20026024, ECO:0000312|WormBase:F12E12.5};
GN ORFNames=F12E12.5 {ECO:0000312|WormBase:F12E12.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=20026024; DOI=10.1016/j.ydbio.2009.12.013;
RA Large E.E., Mathies L.D.;
RT "hunchback and Ikaros-like zinc finger genes control reproductive system
RT development in Caenorhabditis elegans.";
RL Dev. Biol. 339:51-64(2010).
CC -!- FUNCTION: Together with ehn-3, may play a role in gonadogenesis.
CC {ECO:0000269|PubMed:20026024}.
CC -!- TISSUE SPECIFICITY: Expressed in the somatic gonad.
CC {ECO:0000269|PubMed:20026024}.
CC -!- DEVELOPMENTAL STAGE: In the early larval stage of development,
CC expressed in Z1.pa and Z4.ap distal tip cells and their descendants
CC (PubMed:20026024). Not expressed in early embryos (PubMed:20026024).
CC {ECO:0000269|PubMed:20026024}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown does not cause defects in
CC somatic gonad development (PubMed:20026024). RNAi-mediated knockdown in
CC a ehn-3 rd2 mutant background enhances the defects in gonadal
CC development in the ehn-3 single mutant (PubMed:20026024).
CC {ECO:0000269|PubMed:20026024}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BX284602; CCD67483.1; -; Genomic_DNA.
DR RefSeq; NP_494634.1; NM_062233.1.
DR AlphaFoldDB; Q9BLC4; -.
DR IntAct; Q9BLC4; 17.
DR STRING; 6239.F12E12.5; -.
DR PaxDb; Q9BLC4; -.
DR EnsemblMetazoa; F12E12.5.1; F12E12.5.1; WBGene00017406.
DR GeneID; 184388; -.
DR KEGG; cel:CELE_F12E12.5; -.
DR UCSC; F12E12.5; c. elegans.
DR CTD; 184388; -.
DR WormBase; F12E12.5; CE20674; WBGene00017406; sdz-12.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00720000109290; -.
DR HOGENOM; CLU_016943_0_0_1; -.
DR InParanoid; Q9BLC4; -.
DR OMA; PASCAIC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9BLC4; -.
DR PRO; PR:Q9BLC4; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00017406; Expressed in embryo and 1 other tissue.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..330
FT /note="Zinc finger protein sdz-12"
FT /id="PRO_5004324336"
FT ZN_FING 27..48
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 63..85
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 91..113
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 120..144
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 153..176
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 183..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 36951 MW; F862E41588F226BE CRC64;
MSLSSLDAVL SLIATSSTLD QDSAKVPQCQ VCKRKFANQK TLRTHMKHIT CRPGRSNVVN
HKFRCENCEK QFTNKPNLKR HQITHSGSKS KKCSTCQRTF FREDQLQRHL HNHLKERSHF
DCPVLNCSMQ FVFYEGVENH LVNHHHFSYS ESAPCGKCHK LFGSPRHLLV HYHFDHKEAL
RSSAPAPTSS ARLSPITVST SGSPRAQLAI SPQEKPPQKL SINLGTSPMI EEFCEQNSAT
LPNTDQQLSP TLSPNEPRFR NLITSEPTPS FECKHCTIKF HDATMSIMHN ALHAPGSPFK
CAICGAECGN KIVFTMHIIT ASHDFGGIGT
