SDZ1_CAEEL
ID SDZ1_CAEEL Reviewed; 239 AA.
AC P34259;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Skn-1 dependent zygotic transcript 1 protein;
GN Name=sdz-1; ORFNames=B0303.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1538779; DOI=10.1038/356037a0;
RA Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA Waterston R.;
RT "The C. elegans genome sequencing project: a beginning.";
RL Nature 356:37-41(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15581881; DOI=10.1016/j.ydbio.2004.09.015;
RA Robertson S.M., Shetty P., Lin R.;
RT "Identification of lineage-specific zygotic transcripts in early
RT Caenorhabditis elegans embryos.";
RL Dev. Biol. 276:493-507(2004).
RN [4]
RP FUNCTION.
RX PubMed=15737937; DOI=10.1016/j.devcel.2005.01.014;
RA Broitman-Maduro G., Maduro M.F., Rothman J.H.;
RT "The noncanonical binding site of the MED-1 GATA factor defines
RT differentially regulated target genes in the C. elegans mesendoderm.";
RL Dev. Cell 8:427-433(2005).
CC -!- FUNCTION: May have a role in mesendoderm development during
CC embryogenesis. {ECO:0000269|PubMed:15581881,
CC ECO:0000269|PubMed:15737937}.
CC -!- TISSUE SPECIFICITY: Expressed in mesendodermal precursor cells of
CC embryos. {ECO:0000269|PubMed:15581881}.
CC -!- DEVELOPMENTAL STAGE: Tenfold increase in expression between 4-cell and
CC 12-cell embryos. {ECO:0000269|PubMed:15581881}.
CC -!- MISCELLANEOUS: Down-regulated in 12-cell embryos from mutant worms
CC lacking skn-1.
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DR EMBL; FO080163; CCD61711.1; -; Genomic_DNA.
DR PIR; S27789; S27789.
DR RefSeq; NP_498919.2; NM_066518.4.
DR AlphaFoldDB; P34259; -.
DR STRING; 6239.B0303.8; -.
DR PaxDb; P34259; -.
DR PeptideAtlas; P34259; -.
DR PRIDE; P34259; -.
DR EnsemblMetazoa; B0303.8.1; B0303.8.1; WBGene00015129.
DR GeneID; 181916; -.
DR KEGG; cel:CELE_B0303.8; -.
DR UCSC; B0303.8; c. elegans.
DR CTD; 181916; -.
DR WormBase; B0303.8; CE00001; WBGene00015129; sdz-1.
DR eggNOG; ENOG502R7JM; Eukaryota.
DR HOGENOM; CLU_1166781_0_0_1; -.
DR InParanoid; P34259; -.
DR OMA; FCIDEYS; -.
DR OrthoDB; 1775220at2759; -.
DR PhylomeDB; P34259; -.
DR PRO; PR:P34259; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015129; Expressed in embryo and 1 other tissue.
DR GO; GO:0048382; P:mesendoderm development; IMP:UniProtKB.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..239
FT /note="Skn-1 dependent zygotic transcript 1 protein"
FT /id="PRO_0000065065"
SQ SEQUENCE 239 AA; 27341 MW; 65E7C8F53BD87624 CRC64;
MLRYIFFAAI LFFVFPNTES AGFLKFELTA DRDCLLHLEH SSTYSETVRL LAYESRPLEI
YTQGSINEIP VHFQLLHHFS GKALSEAKFQ IFQLKNNGLW DSKVIDTDKV ILSVRSTFYC
ENGYFGPICD RRSRTFAPKS DIQTSTPGYQ TQVLKFDFKI SDDIIIYSSL AFFVLLLIIF
NCILCCYRPK KSQKYLDVSL GSPKVFSICG YSADKSGNTT EYLDAPSRFF SSTKIECVV
