SE14_ORYSJ
ID SE14_ORYSJ Reviewed; 1487 AA.
AC Q10RP4; C7IZW4;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Probable lysine-specific demethylase SE14;
DE EC=1.14.11.-;
DE AltName: Full=Protein PHOTOPERIOD SENSITIVITY 14;
GN Name=SE14; OrderedLocusNames=Os03g0151300, LOC_Os03g05690;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Gimbozu;
RX PubMed=24759811; DOI=10.1371/journal.pone.0096064;
RA Yokoo T., Saito H., Yoshitake Y., Xu Q., Asami T., Tsukiyama T.,
RA Teraishi M., Okumoto Y., Tanisaka T.;
RT "Se14, encoding a JmjC domain-containing protein, plays key roles in long-
RT day suppression of rice flowering through the demethylation of H3K4me3 of
RT RFT1.";
RL PLoS ONE 9:E96064-E96064(2014).
CC -!- FUNCTION: Histone demethylase that demethylates 'Lys-4' (H3K4me) of
CC histone H3. Involved in the control of flowering time. Has a
CC suppressive effect on floral transition under long day conditions
CC through the demethylation of H3K4me3 in the promoter region of the
CC flower-promoting signal HD3B/RFT1. {ECO:0000269|PubMed:24759811}.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000250|UniProtKB:Q53WJ1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250|UniProtKB:Q53WJ1};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
CC -!- DISRUPTION PHENOTYPE: Early flowering. {ECO:0000269|PubMed:24759811}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABF94013.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAH91998.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DP000009; ABF94013.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008209; BAH91998.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015630480.1; XM_015774994.1.
DR AlphaFoldDB; Q10RP4; -.
DR SMR; Q10RP4; -.
DR STRING; 4530.OS03T0151400-01; -.
DR PaxDb; Q10RP4; -.
DR PRIDE; Q10RP4; -.
DR GeneID; 9268736; -.
DR KEGG; osa:9268736; -.
DR eggNOG; KOG1246; Eukaryota.
DR HOGENOM; CLU_587423_0_0_1; -.
DR OrthoDB; 664180at2759; -.
DR BRENDA; 1.14.11.67; 8948.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032452; F:histone demethylase activity; IMP:UniProtKB.
DR GO; GO:0034647; F:histone H3-tri/di/monomethyl-lysine-4 demethylase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IMP:UniProtKB.
DR GO; GO:0048579; P:negative regulation of long-day photoperiodism, flowering; IMP:UniProtKB.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Chromatin regulator; Dioxygenase; Flowering; Iron; Metal-binding; Nucleus;
KW Oxidoreductase; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1487
FT /note="Probable lysine-specific demethylase SE14"
FT /id="PRO_0000430003"
FT DOMAIN 30..71
FT /note="JmjN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00537"
FT DOMAIN 232..398
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT ZN_FING 1377..1400
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1400..1424
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1430..1454
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1460..1486
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 275
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT BINDING 277
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT BINDING 366
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
SQ SEQUENCE 1487 AA; 162965 MW; 962757E0DE7791DC CRC64;
MPPQPPPAAS ASASAPDPAV PAWLRGLPRA PEYRPTESEF ADPIAFLSRV EREAAAYGIC
KVIPPHPRPS RRFVFAHLNR SLVSSCDAPA PSPAAASDSS IPPSSSSPPP VSAAVFTTRH
QELGNPRRGR PTPQVLKQVW QSGERYTLDQ FESKSRAFSK THLAGLHEPT ALAVESLFWK
ASADRPIYIE YANDVPGSGF AAPVQLQRKK KQKRETAPMD EWEKSSGWRL SNSPWNLQAI
ARAPGSLTRF MPDDVPGVTS PMVYIGMLFS WFAWHVEDHD LHSLNFLHTG APKTWYAVPG
DRAVELEEVI RVHGYGGNTD RIASLAVLGE KTTLMSPEVL IDNGVPCCRL VQYPGEFVVT
FPRAYHVGFS HGFNCGEAAN FATPQWLKFA KEAAVRRAVM NYLPMLSHQQ LLYLLAVSFI
SRNPRELLSG IRTSRLRDRK KEDRELLVKQ EFLQDMISEN ELICSFLGKK SVDNVVLWEP
DLLPSLTALH PCSSCSKAPE KKGEDGPRIG STQSSSKDDS SSDGTACMTG TQSKGLSMDS
KQAPEGEKLD TDDGDDLPFD LSIDSGSLTC VACGILGYPF MAILQPSRKA LEEISLVDKE
RYKLSCEKEI CSNVLPCSPN DGSSGCPLIA NRSSSPVENA NLSHQDVKPI RSDISLMGKE
FNGTLGKHIG TSCSCSSENT IHPYGDTETP EKKIPSDCPG SELSKQSGRG DVNVPDVEGS
EETISWNTGC AFARPRIFCL QHALEIEELL ASKGGVHALI ICHADYVKLK ALAISIAEEI
EFQFDYKDVA LANASKSNLH LINISIDDEG YEEEGTDWTS RMGLNLKHSS KIRKETPESQ
EQPPLSFWGL FSKPSPISVV SNLKWLCRKA RTPYKVIGYA SSPDVVATPD KVKPAVTKTQ
IDTSGNAHEN IGSEQTLQQD CVLQESNDVA DMCKRPKVND QDGHSLINIP IAVAEYPMMH
QVCERPVSVS ACDDPICSFD SQDSPTTVAV SAGKPTREQC GAESTELSTV KQFLDNGLIA
EGGSMNFISN HEHLESDNAT SVCKDEQLQV QQDQLAMVLC NNPNTELVAG ELHGGAASST
LENEDSCGNT SYCSDTVLKN SEPDTDDQPE TCDRSVVLVT PKSSCDQMIS SSDRSCSLTL
DCPVSTDAAF SSEKLSMAHD LMGSELQAVH NSKAEVVASL TDVKGAKLNS IHTTQLPHES
PSSDFIISEG AQSASTTAIP RKNGTSMHTE SNSIDILLGV LADESKVSSG KDEVGKASLT
LMTLAGNDQS ADDVTQDEVA EITDPSHGFC SSDIVSRSIG SSNRTNIICY ARRKHKRKSG
SEFNINSPQS LGSFVRSPCE SLRPRTRPAI VEDMTNETKT AEASTANKRK KAKVEAFQCD
IEFCDMTFET KAELRAHQRN ICTDESCGKR FSSHKYLKRH QCVHRDERPF KCPWDGCPMT
FKWLWAQTEH IRVHTGERPY KCSAPDCGQS FRYVSDYSRH RKKFNHY
