SE1L2_MOUSE
ID SE1L2_MOUSE Reviewed; 688 AA.
AC Q3V172; A2AHP5; B0QZY0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Protein sel-1 homolog 2;
DE AltName: Full=Suppressor of lin-12-like protein 2;
DE Short=Sel-1L2;
DE Flags: Precursor;
GN Name=Sel1l2; Synonyms=Gm118;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the sel-1 family. {ECO:0000305}.
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DR EMBL; AK132650; BAE21280.1; -; mRNA.
DR EMBL; AL731795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50732.1; -.
DR RefSeq; NP_001028468.1; NM_001033296.2.
DR AlphaFoldDB; Q3V172; -.
DR SMR; Q3V172; -.
DR BioGRID; 230753; 7.
DR STRING; 10090.ENSMUSP00000113800; -.
DR GlyGen; Q3V172; 2 sites.
DR iPTMnet; Q3V172; -.
DR PhosphoSitePlus; Q3V172; -.
DR EPD; Q3V172; -.
DR PaxDb; Q3V172; -.
DR PRIDE; Q3V172; -.
DR ProteomicsDB; 256761; -.
DR Antibodypedia; 67355; 21 antibodies from 8 providers.
DR Ensembl; ENSMUST00000122367; ENSMUSP00000113800; ENSMUSG00000074764.
DR GeneID; 228684; -.
DR KEGG; mmu:228684; -.
DR UCSC; uc008mpq.1; mouse.
DR CTD; 80343; -.
DR MGI; MGI:2684964; Sel1l2.
DR VEuPathDB; HostDB:ENSMUSG00000074764; -.
DR eggNOG; KOG1550; Eukaryota.
DR GeneTree; ENSGT00940000161298; -.
DR HOGENOM; CLU_007931_2_1_1; -.
DR InParanoid; Q3V172; -.
DR OMA; IAANKYH; -.
DR OrthoDB; 357553at2759; -.
DR PhylomeDB; Q3V172; -.
DR TreeFam; TF315257; -.
DR BioGRID-ORCS; 228684; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Sel1l2; mouse.
DR PRO; PR:Q3V172; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3V172; protein.
DR Bgee; ENSMUSG00000074764; Expressed in spermatid and 15 other tissues.
DR ExpressionAtlas; Q3V172; baseline and differential.
DR Genevisible; Q3V172; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0036503; P:ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF08238; Sel1; 11.
DR SMART; SM00671; SEL1; 11.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..688
FT /note="Protein sel-1 homolog 2"
FT /id="PRO_0000305160"
FT TOPO_DOM 19..662
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 684..688
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 107..142
FT /note="Sel1-like 1"
FT REPEAT 143..178
FT /note="Sel1-like 2"
FT REPEAT 179..214
FT /note="Sel1-like 3"
FT REPEAT 215..250
FT /note="Sel1-like 4"
FT REPEAT 297..333
FT /note="Sel1-like 5"
FT REPEAT 334..370
FT /note="Sel1-like 6"
FT REPEAT 371..406
FT /note="Sel1-like 7"
FT REPEAT 407..442
FT /note="Sel1-like 8"
FT REPEAT 443..478
FT /note="Sel1-like 9"
FT REPEAT 551..586
FT /note="Sel1-like 10"
FT REPEAT 588..623
FT /note="Sel1-like 11"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 688 AA; 77989 MW; 1C76B415991975E3 CRC64;
MNPLALLVEI LIIIEVTTKN TEAERYNRKQ KEVNVTTQVS VSKVKQFLLY LLEQGNANKI
TNKRENPLEK KKHQHKLKIK GIQNKNLLKR NQNYFKNPAK KSITDEGDEL FKMGNKILQE
SKSQKQKTEA YTLFTRAANM GNLKAMEKMA DAWLFGSFGM QNITAAIQLY ESLAKEGSYK
AQNALGFLSS YGIGMEYDQA KALIYYTFGS AGGSMMSQMI LGYRYLSGIN VLQNCEVALN
HYKKVADYIA DKLEKSEGIP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ
VSLGQLHLIG RKGLDQDYSK ALYYFLKAAK AGSANAMAFI GKMYFEGNAA APQNNATAFK
YFSMAASKGN AIGLHGLGLL YFHGKGVPVN YGEALKYFQK AAEKGWPNAQ FQLGFMYYSG
SGVWKDYKLA FKYFYLASQS GQPLAIYYLA EMYATGTGVL RSCRTAVELY KGVCELGHWA
EKFLTAYFAY KDGDIDSSLI QYALLAEMGY EVAQSNSAFI LESKKAKILG KEKLYPMALL
LWNRAAIQGN AFARVKIGDY HYYGYGTKKD YETAATHYSI AADKHHSAQA MFNLAYMYEH
GLGIAKDIHL ARRLYDMAAQ TSPDAHIPVF FALMKLETMH LLHDILFFNF TMKWKWLKLD
STVGPYWDLL VIGLIVAMLI FLLRNRHR
