ID   SE1L2_RAT               Reviewed;         688 AA.
AC   Q5XI05;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Protein sel-1 homolog 2;
DE   AltName: Full=Suppressor of lin-12-like protein 2;
DE            Short=Sel-1L2;
DE   Flags: Precursor;
GN   Name=Sel1l2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the sel-1 family. {ECO:0000305}.
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DR   EMBL; BC083893; AAH83893.1; -; mRNA.
DR   RefSeq; NP_001014071.1; NM_001014049.1.
DR   AlphaFoldDB; Q5XI05; -.
DR   SMR; Q5XI05; -.
DR   BioGRID; 259950; 1.
DR   STRING; 10116.ENSRNOP00000036379; -.
DR   GlyGen; Q5XI05; 2 sites.
DR   PaxDb; Q5XI05; -.
DR   GeneID; 311470; -.
DR   KEGG; rno:311470; -.
DR   UCSC; RGD:1311278; rat.
DR   CTD; 80343; -.
DR   RGD; 1311278; Sel1l2.
DR   eggNOG; KOG1550; Eukaryota.
DR   InParanoid; Q5XI05; -.
DR   OrthoDB; 357553at2759; -.
DR   PhylomeDB; Q5XI05; -.
DR   PRO; PR:Q5XI05; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036503; P:ERAD pathway; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   Pfam; PF08238; Sel1; 11.
DR   SMART; SM00671; SEL1; 11.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..688
FT                   /note="Protein sel-1 homolog 2"
FT                   /id="PRO_0000305161"
FT   TOPO_DOM        19..662
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        663..683
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        684..688
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          107..142
FT                   /note="Sel1-like 1"
FT   REPEAT          143..178
FT                   /note="Sel1-like 2"
FT   REPEAT          179..214
FT                   /note="Sel1-like 3"
FT   REPEAT          215..250
FT                   /note="Sel1-like 4"
FT   REPEAT          297..333
FT                   /note="Sel1-like 5"
FT   REPEAT          334..370
FT                   /note="Sel1-like 6"
FT   REPEAT          371..406
FT                   /note="Sel1-like 7"
FT   REPEAT          407..442
FT                   /note="Sel1-like 8"
FT   REPEAT          443..478
FT                   /note="Sel1-like 9"
FT   REPEAT          551..586
FT                   /note="Sel1-like 10"
FT   REPEAT          588..623
FT                   /note="Sel1-like 11"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   688 AA;  77831 MW;  D61A64A51DE98387 CRC64;
     MNPLALLVEI LIIIEVTTKN SEAERYNRKQ KEVNVTTQVS VSKVKQFLSH LLEQGKANKI
     ANKRENPLEK KKHQHKLKIK GIQNKNLLKR NQNYFKKPAK KSITDKGDEL FKMGNKILQE
     SKSQKQKTEA YTFFTRAADM GNLKAMEKMA DALLFGSFGM QNITAAIQLY ESLAKEGSYK
     AQNALGFLSS YGIGMEYDQA KALIYYTFGS AGGSMMSQMI LGYRYLSGIN VLQNCEVALN
     HYKKVADYIA DKLEKSEGIP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ
     VSLGQLHLIG RKGLDQDYSK ALYYFLKAAK AGSANAMAFI GKMYLEGNAA APQNNATAFK
     YFSMAASKGN AIGLHGLGLL YFHGKGVPVN YGEALKYFQK AAEKGWPNAQ FHLGFMYYSG
     SGVWKDYKLA FKYFYLASQS GQPLAIYYLA EMYATGTGVL RSCRTAVEPY KGVCELGHWA
     EKFLTAYFAY KDGDVDSSLI QYALLAEMGY EVAQSNSAFI LESKKAKILG KEKMYPMALL
     LWNRAAIQGN AFARVKIGDY HYYGYGTKKD YETAATHYSI AADKHHSAQA MFNLAYMYEH
     GLGIAQDIHL ARRLYDMAAQ TSPDAHIPVF FALMKLETMH FLQDILFFNF TTKWKWLKLD
     STIGPYWDLL VIGLIVVVLI FLLRNHHR