SE1L3_MOUSE
ID SE1L3_MOUSE Reviewed; 1137 AA.
AC Q80TS8; E9QPJ6; Q148Y5; Q505D2; Q8BMN0; Q8BYY3; Q8R0K7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein sel-1 homolog 3;
DE AltName: Full=Suppressor of lin-12-like protein 3;
DE Short=Sel-1L3;
GN Name=Sel1l3; Synonyms=Kiaa0746;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Pituitary, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 720-1137.
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80TS8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80TS8-2; Sequence=VSP_031813;
CC Name=3;
CC IsoId=Q80TS8-3; Sequence=VSP_031814, VSP_031815;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH26655.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC65644.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK122362; BAC65644.1; ALT_INIT; mRNA.
DR EMBL; AK030487; BAC26986.1; -; mRNA.
DR EMBL; AK037220; BAC29759.1; -; mRNA.
DR EMBL; AC122522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026655; AAH26655.1; ALT_INIT; mRNA.
DR EMBL; BC094607; AAH94607.1; -; mRNA.
DR EMBL; BC117915; AAI17916.1; -; mRNA.
DR EMBL; BC117916; AAI17917.1; -; mRNA.
DR CCDS; CCDS51501.1; -. [Q80TS8-1]
DR RefSeq; NP_766298.2; NM_172710.3. [Q80TS8-1]
DR RefSeq; XP_011239032.1; XM_011240730.1. [Q80TS8-2]
DR AlphaFoldDB; Q80TS8; -.
DR SMR; Q80TS8; -.
DR STRING; 10090.ENSMUSP00000031090; -.
DR GlyGen; Q80TS8; 3 sites.
DR iPTMnet; Q80TS8; -.
DR PhosphoSitePlus; Q80TS8; -.
DR PaxDb; Q80TS8; -.
DR PeptideAtlas; Q80TS8; -.
DR PRIDE; Q80TS8; -.
DR ProteomicsDB; 256762; -. [Q80TS8-1]
DR ProteomicsDB; 256763; -. [Q80TS8-2]
DR ProteomicsDB; 256764; -. [Q80TS8-3]
DR Antibodypedia; 51970; 72 antibodies from 16 providers.
DR Ensembl; ENSMUST00000031090; ENSMUSP00000031090; ENSMUSG00000029189. [Q80TS8-1]
DR GeneID; 231238; -.
DR KEGG; mmu:231238; -.
DR UCSC; uc008xlc.1; mouse. [Q80TS8-1]
DR UCSC; uc008xld.1; mouse. [Q80TS8-3]
DR CTD; 23231; -.
DR MGI; MGI:1916941; Sel1l3.
DR VEuPathDB; HostDB:ENSMUSG00000029189; -.
DR eggNOG; KOG1550; Eukaryota.
DR GeneTree; ENSGT00940000159983; -.
DR HOGENOM; CLU_011209_0_0_1; -.
DR InParanoid; Q80TS8; -.
DR OMA; YLLKWCQ; -.
DR OrthoDB; 438059at2759; -.
DR PhylomeDB; Q80TS8; -.
DR TreeFam; TF315257; -.
DR BioGRID-ORCS; 231238; 0 hits in 76 CRISPR screens.
DR ChiTaRS; Sel1l3; mouse.
DR PRO; PR:Q80TS8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q80TS8; protein.
DR Bgee; ENSMUSG00000029189; Expressed in lacrimal gland and 223 other tissues.
DR Genevisible; Q80TS8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR042756; Sel-1L3.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR44444; PTHR44444; 1.
DR Pfam; PF08238; Sel1; 5.
DR SMART; SM00671; SEL1; 8.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..1137
FT /note="Protein sel-1 homolog 3"
FT /id="PRO_0000321895"
FT TRANSMEM 1067..1087
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 575..609
FT /note="Sel1-like 1"
FT REPEAT 611..647
FT /note="Sel1-like 2"
FT REPEAT 694..730
FT /note="Sel1-like 3"
FT REPEAT 732..767
FT /note="Sel1-like 4"
FT REPEAT 768..800
FT /note="Sel1-like 5"
FT REPEAT 801..839
FT /note="Sel1-like 6"
FT REPEAT 840..877
FT /note="Sel1-like 7"
FT REPEAT 952..988
FT /note="Sel1-like 8"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 613
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68CR1"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 387
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 942
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..158
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031813"
FT VAR_SEQ 698..725
FT /note="QRLAQMLFWGQQGVAKNPEAAIEWYAKG -> VRASPSWSICQSFQMRLQSN
FT KASPSSAA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031814"
FT VAR_SEQ 726..1137
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031815"
FT CONFLICT 413
FT /note="V -> M (in Ref. 1; BAC65644 and 4; AAI17916/
FT AAI17917)"
FT /evidence="ECO:0000305"
FT CONFLICT 768
FT /note="H -> Y (in Ref. 4; AAH94607)"
FT /evidence="ECO:0000305"
FT CONFLICT 974
FT /note="E -> D (in Ref. 4; AAH94607)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1137 AA; 128680 MW; DC2F94A23F3AA92D CRC64;
MQWRGAGLWW PRRRQQQQQQ QPPPPAFGPP AAAMVPPSRG VSPGLGGRPT SALLFLCYLN
FVPSLGRQTS LTTSVLPRTE QSTTYADFIY FTAFEGSVRN VSEVSVEYLC SQPCVVHLEA
VVSSEFRSSI PVYKKRWRNE KHLHTSRTQT VHVKFPSIMV YRDDYLIRHP ISVSTVILRA
WITHWHSGGG LNVRGEENLL HAVAKNYTLL QTVPPFERPF KDHQVCLEWN MDYLWSLWAN
RIPQCPLESD AVALLSFPYA SSGENTGIVK KLQNFQNREL EATRSQRVDY PMVTISLWLY
LLHYCEASLC GILYFVDSNE MYGTPSVFLT EDGSLHIQMH LVKGEDLAVK TKFTIPLKEW
CRLDISFNGG QIVVTASIGW DLKSYHNQTI SFHEDFYYND TAGYFIIGGS RYVAGIEGFF
GPVKYYRLRS LHPAQVLNPF LEKELAEQIK LYYERCTEVQ DIISSYAATV QVGGERRETC
DFHNSYLDLK RKYGRAEVCR GLPWEKELRD RHPSLFQSLL QMDLLTVPWN QNDSVLEIGA
RIFEKAVKRL SGVDGLHQIS SAIPFLMDSS CCGYHKASYY LTVFYETGLN GPRDQLQGML
YSLVGGQGSE RLSSMNLGYK HYQGVDSYPL DWELSYAYYS NIATKTPLDQ HTLQGDQAYV
ETIRLKDDEI LKVQTKEDGD VFMWLKHEAT RGNAAAQQRL AQMLFWGQQG VAKNPEAAIE
WYAKGALETE DPALIYDYAI VLFKGQGVKK NRRLALELMK KAASKGLHQA VNGLGWYYHK
FRKNYAKAAK YWLKAEEMGN PDASYNLGVL YLDGIFPGVP GRNLTLAGEY FHKAAQGGHI
EGTLWCSLYY ITGNLETFPR DPEKAVVWAK HVAEKNGYLG HVIRKGLNAY LEGLWHEALL
YYVLAAETGI EVSQTNLAHI CEERPDLAGR YLGVNCVWRY YNFSVFQIDA PSFAYLKMGD
LYYYGHQNQS QDLELSVQMY AQAALDGDSQ GFFNLAALIE EGAVIPHHIL EFLEIDPSLH
SSNTSILQEL YERCWSLSNE ESLSPCSLAW LYLHLRLLWG AVLHSALIYF LGTFLLSVVI
AWMVLYLQYI SASGSSPAPA WVSADPTSST PSPAVPPAAD ASDHDPPMMA NGPEPRG
