SE6L1_HUMAN
ID SE6L1_HUMAN Reviewed; 1024 AA.
AC Q9BYH1; A0AUW7; B0QYG4; B0QYG5; B7ZLJ6; G8JLP3; O95917; Q5THY5; Q6IBZ4;
AC Q6UXD4; Q9NUI3; Q9NUI4; Q9NUI5; Q9Y2E1; Q9Y3J6;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Seizure 6-like protein;
DE Flags: Precursor;
GN Name=SEZ6L; Synonyms=KIAA0927; ORFNames=UNQ2542/PRO6094;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=11175339; DOI=10.1038/sj.onc.1204031;
RA Nishioka M., Kohno T., Takahashi M., Niki T., Yamada T., Sone S.,
RA Yokota J.;
RT "Identification of a 428-kb homozygously deleted region disrupting the
RT SEZ6L gene at 22q12.1 in a lung cancer cell line.";
RL Oncogene 19:6251-6260(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Fetal brain;
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7), AND VARIANT
RP ILE-430.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP GENE EXPRESSION REGULATION.
RX PubMed=11992124; DOI=10.1038/ng892;
RA Suzuki H., Gabrielson E., Chen W., Anbazhagan R., Van Engeland M.,
RA Weijenberg M.P., Herman J.G., Baylin S.B.;
RT "A genomic screen for genes upregulated by demethylation and histone
RT deacetylase inhibition in human colorectal cancer.";
RL Nat. Genet. 31:141-149(2002).
RN [9]
RP GLYCOSYLATION AT SER-49, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=23234360; DOI=10.1021/pr300963h;
RA Halim A., Ruetschi U., Larson G., Nilsson J.;
RT "LC-MS/MS characterization of O-glycosylation sites and glycan structures
RT of human cerebrospinal fluid glycoproteins.";
RL J. Proteome Res. 12:573-584(2013).
RN [10]
RP STRUCTURE BY NMR OF 745-802, AND DISULFIDE BONDS.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the zinc finger domains (1-87) from human F-box only
RT protein.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: May contribute to specialized endoplasmic reticulum functions
CC in neurons. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BYH1-5; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-12012146, EBI-473189;
CC Q9BYH1-5; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12012146, EBI-741480;
CC Q9BYH1-5; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12012146, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=4;
CC IsoId=Q9BYH1-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9BYH1-2; Sequence=VSP_003976, VSP_003977, VSP_003980;
CC Name=2;
CC IsoId=Q9BYH1-3; Sequence=VSP_003976, VSP_003979, VSP_003980;
CC Name=3;
CC IsoId=Q9BYH1-4; Sequence=VSP_003981, VSP_003978;
CC Name=5;
CC IsoId=Q9BYH1-5; Sequence=VSP_013022;
CC Name=6;
CC IsoId=Q9BYH1-6; Sequence=VSP_003979;
CC Name=7;
CC IsoId=Q9BYH1-7; Sequence=VSP_003978;
CC -!- TISSUE SPECIFICITY: Widely expressed, including adult and fetal brains
CC and lungs. Not expressed in all lung cancer cell lines.
CC -!- PTM: O-glycosylated. {ECO:0000269|PubMed:23234360}.
CC -!- SIMILARITY: Belongs to the SEZ6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA76771.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB041736; BAB40970.1; -; mRNA.
DR EMBL; AB023144; BAA76771.2; ALT_INIT; mRNA.
DR EMBL; AL035545; CAB37431.1; -; mRNA.
DR EMBL; AL050253; CAB43355.1; -; mRNA.
DR EMBL; AY358405; AAQ88771.1; -; mRNA.
DR EMBL; CR456574; CAG30460.1; -; mRNA.
DR EMBL; AL022337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL023513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL078460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL080273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126115; AAI26116.1; -; mRNA.
DR EMBL; BC143851; AAI43852.1; -; mRNA.
DR CCDS; CCDS13833.1; -. [Q9BYH1-1]
DR CCDS; CCDS54508.1; -. [Q9BYH1-6]
DR CCDS; CCDS54509.1; -. [Q9BYH1-7]
DR CCDS; CCDS54510.1; -. [Q9BYH1-5]
DR CCDS; CCDS54511.1; -. [Q9BYH1-4]
DR RefSeq; NP_001171702.1; NM_001184773.1. [Q9BYH1-6]
DR RefSeq; NP_001171703.1; NM_001184774.1. [Q9BYH1-7]
DR RefSeq; NP_001171704.1; NM_001184775.1.
DR RefSeq; NP_001171705.1; NM_001184776.1. [Q9BYH1-4]
DR RefSeq; NP_001171706.1; NM_001184777.1. [Q9BYH1-5]
DR RefSeq; NP_066938.2; NM_021115.4. [Q9BYH1-1]
DR PDB; 2YRA; NMR; -; A=745-802.
DR PDBsum; 2YRA; -.
DR AlphaFoldDB; Q9BYH1; -.
DR SMR; Q9BYH1; -.
DR BioGRID; 117088; 9.
DR IntAct; Q9BYH1; 4.
DR STRING; 9606.ENSP00000248933; -.
DR GlyGen; Q9BYH1; 14 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9BYH1; -.
DR PhosphoSitePlus; Q9BYH1; -.
DR BioMuta; SEZ6L; -.
DR DMDM; 22002000; -.
DR jPOST; Q9BYH1; -.
DR MassIVE; Q9BYH1; -.
DR PaxDb; Q9BYH1; -.
DR PeptideAtlas; Q9BYH1; -.
DR PRIDE; Q9BYH1; -.
DR ProteomicsDB; 34294; -.
DR ProteomicsDB; 79643; -. [Q9BYH1-1]
DR ProteomicsDB; 79644; -. [Q9BYH1-2]
DR ProteomicsDB; 79645; -. [Q9BYH1-3]
DR ProteomicsDB; 79646; -. [Q9BYH1-4]
DR ProteomicsDB; 79647; -. [Q9BYH1-5]
DR ProteomicsDB; 79648; -. [Q9BYH1-6]
DR Antibodypedia; 54796; 68 antibodies from 17 providers.
DR DNASU; 23544; -.
DR Ensembl; ENST00000248933.11; ENSP00000248933.6; ENSG00000100095.19. [Q9BYH1-1]
DR Ensembl; ENST00000343706.8; ENSP00000342661.4; ENSG00000100095.19. [Q9BYH1-5]
DR Ensembl; ENST00000360929.7; ENSP00000354185.3; ENSG00000100095.19. [Q9BYH1-4]
DR Ensembl; ENST00000404234.7; ENSP00000384772.3; ENSG00000100095.19. [Q9BYH1-6]
DR Ensembl; ENST00000629590.2; ENSP00000485720.1; ENSG00000100095.19. [Q9BYH1-7]
DR GeneID; 23544; -.
DR KEGG; hsa:23544; -.
DR MANE-Select; ENST00000248933.11; ENSP00000248933.6; NM_021115.5; NP_066938.2.
DR UCSC; uc003acb.4; human. [Q9BYH1-1]
DR CTD; 23544; -.
DR DisGeNET; 23544; -.
DR GeneCards; SEZ6L; -.
DR HGNC; HGNC:10763; SEZ6L.
DR HPA; ENSG00000100095; Tissue enriched (brain).
DR MIM; 607021; gene.
DR neXtProt; NX_Q9BYH1; -.
DR OpenTargets; ENSG00000100095; -.
DR PharmGKB; PA35681; -.
DR VEuPathDB; HostDB:ENSG00000100095; -.
DR eggNOG; ENOG502QVYR; Eukaryota.
DR GeneTree; ENSGT00940000158873; -.
DR InParanoid; Q9BYH1; -.
DR OMA; NRDCFGN; -.
DR OrthoDB; 126806at2759; -.
DR PhylomeDB; Q9BYH1; -.
DR TreeFam; TF330037; -.
DR PathwayCommons; Q9BYH1; -.
DR SignaLink; Q9BYH1; -.
DR BioGRID-ORCS; 23544; 23 hits in 1064 CRISPR screens.
DR ChiTaRS; SEZ6L; human.
DR EvolutionaryTrace; Q9BYH1; -.
DR GeneWiki; SEZ6L; -.
DR GenomeRNAi; 23544; -.
DR Pharos; Q9BYH1; Tbio.
DR PRO; PR:Q9BYH1; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BYH1; protein.
DR Bgee; ENSG00000100095; Expressed in ganglionic eminence and 140 other tissues.
DR ExpressionAtlas; Q9BYH1; baseline and differential.
DR Genevisible; Q9BYH1; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IBA:GO_Central.
DR GO; GO:0060074; P:synapse maturation; IBA:GO_Central.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; -; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; SSF49854; 3.
DR SUPFAM; SSF57535; SSF57535; 5.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS50923; SUSHI; 5.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disulfide bond; Endoplasmic reticulum;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Sushi;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..1024
FT /note="Seizure 6-like protein"
FT /id="PRO_0000022323"
FT TOPO_DOM 29..958
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 959..979
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 980..1024
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 281..389
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 391..450
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 452..562
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 565..626
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 628..739
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 743..802
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 804..867
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 871..932
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 33..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..161
FT /note="O-glycosylated at one site"
FT REGION 176..180
FT /note="O-glycosylated at one site"
FT REGION 212..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 49
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000269|PubMed:23234360"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 435
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 458
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 474
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 514
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 576
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 618
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 674
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 742
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 281..308
FT /evidence="ECO:0000250"
FT DISULFID 393..433
FT /evidence="ECO:0000250"
FT DISULFID 419..448
FT /evidence="ECO:0000250"
FT DISULFID 567..609
FT /evidence="ECO:0000250"
FT DISULFID 594..624
FT /evidence="ECO:0000250"
FT DISULFID 745..787
FT /evidence="ECO:0000269|Ref.10"
FT DISULFID 773..800
FT /evidence="ECO:0000269|Ref.10"
FT DISULFID 806..848
FT /evidence="ECO:0000250"
FT DISULFID 834..865
FT /evidence="ECO:0000250"
FT DISULFID 873..915
FT /evidence="ECO:0000250"
FT DISULFID 901..930
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..227
FT /note="Missing (in isoform 1 and isoform 2)"
FT /evidence="ECO:0000303|PubMed:12529303,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_003976"
FT VAR_SEQ 803..867
FT /note="IMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETG
FT TPIWTSRLPHCVS -> T (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10231032"
FT /id="VSP_003981"
FT VAR_SEQ 867..943
FT /note="SEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILG
FT QPSHWNGPLPVCKVNQDSFEHALEV -> L (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15461802"
FT /id="VSP_013022"
FT VAR_SEQ 868..944
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:12529303,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_003977"
FT VAR_SEQ 933..943
FT /note="Missing (in isoform 3 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:10231032,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_003978"
FT VAR_SEQ 943
FT /note="Missing (in isoform 2 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:12529303,
FT ECO:0000303|PubMed:12975309"
FT /id="VSP_003979"
FT VAR_SEQ 1016..1024
FT /note="ETREYEVSI -> GTQKV (in isoform 1 and isoform 2)"
FT /evidence="ECO:0000303|PubMed:12529303,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_003980"
FT VARIANT 52
FT /note="P -> L (in dbSNP:rs6004989)"
FT /id="VAR_043338"
FT VARIANT 185
FT /note="W -> L (in dbSNP:rs137203)"
FT /id="VAR_024348"
FT VARIANT 430
FT /note="M -> I (in dbSNP:rs663048)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_020330"
FT VARIANT 671
FT /note="Q -> H (in dbSNP:rs586542)"
FT /id="VAR_043339"
FT STRAND 754..756
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 759..762
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 768..773
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 777..781
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 783..787
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 793..795
FT /evidence="ECO:0007829|PDB:2YRA"
FT STRAND 799..802
FT /evidence="ECO:0007829|PDB:2YRA"
SQ SEQUENCE 1024 AA; 111782 MW; CBC0679E22C23B6E CRC64;
MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE
HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP
SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS
EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM
ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL
PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI
RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH
LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI
WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI
RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL
EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV
GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD
PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV
GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL
EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM
CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEVAEAAAET SLEGGNMALA
IFIPVLIISL LLGGAYIYIT RCRYYSNLRL PLMYSHPYSQ ITVETEFDNP IYETGETREY
EVSI
