SE6L2_HUMAN
ID SE6L2_HUMAN Reviewed; 910 AA.
AC Q6UXD5; B7Z1N0; F5H293; H7BXQ6; Q9BW82; Q9UJ45; Q9UJ46; Q9UJ47;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Seizure 6-like protein 2;
DE Flags: Precursor;
GN Name=SEZ6L2; Synonyms=PSK; ORFNames=UNQ1903/PRO4349;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4).
RA Schrotz-King P., King A., Nyborg Nielsen P., Andersen J., Kuster B.,
RA Mann M.;
RT "Identification of novel seizure-related proteins from the human brain.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-74.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), AND VARIANT PRO-74.
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), AND VARIANT PRO-74.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16863507; DOI=10.1111/j.1349-7006.2006.00258.x;
RA Ishikawa N., Daigo Y., Takano A., Taniwaki M., Kato T., Tanaka S.,
RA Yasui W., Takeshima Y., Inai K., Nishimura H., Tsuchiya E., Kohno N.,
RA Nakamura Y.;
RT "Characterization of SEZ6L2 cell-surface protein as a novel prognostic
RT marker for lung cancer.";
RL Cancer Sci. 97:737-745(2006).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS], SIGNAL SEQUENCE CLEAVAGE SITE, AND
RP STRUCTURE OF CARBOHYDRATES.
RC TISSUE=Cerebrospinal fluid;
RX PubMed=19838169; DOI=10.1038/nmeth.1392;
RA Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G.,
RA Larson G.;
RT "Enrichment of glycopeptides for glycan structure and attachment site
RT identification.";
RL Nat. Methods 6:809-811(2009).
CC -!- FUNCTION: May contribute to specialized endoplasmic reticulum functions
CC in neurons. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16863507};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:16863507}.
CC Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Detected on cell surface of lung-
CC cancer.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q6UXD5-1; Sequence=Displayed;
CC Name=2; Synonyms=psk-3;
CC IsoId=Q6UXD5-2; Sequence=VSP_033595;
CC Name=3; Synonyms=psk-1;
CC IsoId=Q6UXD5-3; Sequence=VSP_033595, VSP_033596;
CC Name=4; Synonyms=psk-2;
CC IsoId=Q6UXD5-4; Sequence=VSP_033595, VSP_033597;
CC Name=5;
CC IsoId=Q6UXD5-5; Sequence=VSP_044739, VSP_033596;
CC Name=6;
CC IsoId=Q6UXD5-6; Sequence=VSP_045702, VSP_045703;
CC -!- INDUCTION: Increased expression in the majority of primary lung cancers
CC and lung-cell lines tested. {ECO:0000269|PubMed:16863507}.
CC -!- PTM: O-glycosylated with core 1 or possibly core 8 glycans.
CC {ECO:0000269|PubMed:19838169}.
CC -!- MISCELLANEOUS: May serve as a prognostic marker for lung cancers.
CC -!- SIMILARITY: Belongs to the SEZ6 family. {ECO:0000305}.
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DR EMBL; AJ245820; CAB57950.1; -; mRNA.
DR EMBL; AJ245821; CAB57951.1; -; mRNA.
DR EMBL; AJ245822; CAB57952.1; -; mRNA.
DR EMBL; AY358404; AAQ88770.1; -; mRNA.
DR EMBL; AK293675; BAH11566.1; -; mRNA.
DR EMBL; AC120114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000567; AAH00567.1; -; mRNA.
DR CCDS; CCDS10658.1; -. [Q6UXD5-3]
DR CCDS; CCDS10659.1; -. [Q6UXD5-1]
DR CCDS; CCDS45458.1; -. [Q6UXD5-6]
DR CCDS; CCDS58447.1; -. [Q6UXD5-5]
DR RefSeq; NP_001107571.1; NM_001114099.2. [Q6UXD5-2]
DR RefSeq; NP_001107572.1; NM_001114100.2. [Q6UXD5-6]
DR RefSeq; NP_001230261.1; NM_001243332.1.
DR RefSeq; NP_001230262.1; NM_001243333.1. [Q6UXD5-5]
DR RefSeq; NP_036542.1; NM_012410.3. [Q6UXD5-3]
DR RefSeq; NP_963869.2; NM_201575.3. [Q6UXD5-1]
DR AlphaFoldDB; Q6UXD5; -.
DR SMR; Q6UXD5; -.
DR BioGRID; 117694; 48.
DR IntAct; Q6UXD5; 10.
DR STRING; 9606.ENSP00000481917; -.
DR GlyConnect; 1974; 11 N-Linked glycans (2 sites).
DR GlyGen; Q6UXD5; 14 sites, 11 N-linked glycans (2 sites), 3 O-linked glycans (5 sites).
DR iPTMnet; Q6UXD5; -.
DR PhosphoSitePlus; Q6UXD5; -.
DR BioMuta; SEZ6L2; -.
DR DMDM; 334302856; -.
DR CPTAC; CPTAC-1515; -.
DR EPD; Q6UXD5; -.
DR jPOST; Q6UXD5; -.
DR MassIVE; Q6UXD5; -.
DR MaxQB; Q6UXD5; -.
DR PaxDb; Q6UXD5; -.
DR PeptideAtlas; Q6UXD5; -.
DR PRIDE; Q6UXD5; -.
DR ProteomicsDB; 25901; -.
DR ProteomicsDB; 43361; -.
DR ProteomicsDB; 67592; -. [Q6UXD5-1]
DR ProteomicsDB; 67593; -. [Q6UXD5-2]
DR ProteomicsDB; 67594; -. [Q6UXD5-3]
DR ProteomicsDB; 67595; -. [Q6UXD5-4]
DR Antibodypedia; 54161; 88 antibodies from 17 providers.
DR DNASU; 26470; -.
DR Ensembl; ENST00000308713.9; ENSP00000312550.5; ENSG00000174938.15. [Q6UXD5-1]
DR Ensembl; ENST00000346932.9; ENSP00000319215.6; ENSG00000174938.15. [Q6UXD5-6]
DR Ensembl; ENST00000350527.7; ENSP00000310206.3; ENSG00000174938.15. [Q6UXD5-3]
DR Ensembl; ENST00000537485.5; ENSP00000439412.1; ENSG00000174938.15. [Q6UXD5-5]
DR GeneID; 26470; -.
DR KEGG; hsa:26470; -.
DR UCSC; uc002dup.5; human. [Q6UXD5-1]
DR CTD; 26470; -.
DR DisGeNET; 26470; -.
DR GeneCards; SEZ6L2; -.
DR HGNC; HGNC:30844; SEZ6L2.
DR HPA; ENSG00000174938; Tissue enhanced (brain, pituitary gland).
DR MIM; 616667; gene.
DR neXtProt; NX_Q6UXD5; -.
DR OpenTargets; ENSG00000174938; -.
DR PharmGKB; PA134924025; -.
DR VEuPathDB; HostDB:ENSG00000174938; -.
DR eggNOG; ENOG502QS53; Eukaryota.
DR GeneTree; ENSGT00940000160492; -.
DR HOGENOM; CLU_011474_3_0_1; -.
DR InParanoid; Q6UXD5; -.
DR OrthoDB; 126806at2759; -.
DR PhylomeDB; Q6UXD5; -.
DR TreeFam; TF330037; -.
DR PathwayCommons; Q6UXD5; -.
DR SignaLink; Q6UXD5; -.
DR BioGRID-ORCS; 26470; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; SEZ6L2; human.
DR GenomeRNAi; 26470; -.
DR Pharos; Q6UXD5; Tbio.
DR PRO; PR:Q6UXD5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q6UXD5; protein.
DR Bgee; ENSG00000174938; Expressed in right hemisphere of cerebellum and 164 other tissues.
DR ExpressionAtlas; Q6UXD5; baseline and differential.
DR Genevisible; Q6UXD5; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IBA:GO_Central.
DR GO; GO:0060074; P:synapse maturation; IBA:GO_Central.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; -; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; SSF49854; 3.
DR SUPFAM; SSF57535; SSF57535; 5.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS50923; SUSHI; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Endoplasmic reticulum;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Sushi;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000269|PubMed:19838169"
FT CHAIN 28..910
FT /note="Seizure 6-like protein 2"
FT /id="PRO_0000333888"
FT TOPO_DOM 28..844
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 866..910
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 173..286
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 288..347
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 349..459
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 462..525
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 527..638
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 642..701
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 703..766
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 769..830
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 41..48
FT /note="O-glycosylated at one site"
FT REGION 65..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 373
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 641
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 173..202
FT /evidence="ECO:0000250"
FT DISULFID 290..330
FT /evidence="ECO:0000250"
FT DISULFID 316..345
FT /evidence="ECO:0000250"
FT DISULFID 349..376
FT /evidence="ECO:0000250"
FT DISULFID 464..508
FT /evidence="ECO:0000250"
FT DISULFID 491..523
FT /evidence="ECO:0000250"
FT DISULFID 527..553
FT /evidence="ECO:0000250"
FT DISULFID 644..686
FT /evidence="ECO:0000250"
FT DISULFID 672..699
FT /evidence="ECO:0000250"
FT DISULFID 705..747
FT /evidence="ECO:0000250"
FT DISULFID 733..764
FT /evidence="ECO:0000250"
FT DISULFID 771..813
FT /evidence="ECO:0000250"
FT DISULFID 799..828
FT /evidence="ECO:0000250"
FT VAR_SEQ 27..70
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044739"
FT VAR_SEQ 72..141
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033595"
FT VAR_SEQ 171..284
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045702"
FT VAR_SEQ 651..910
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033597"
FT VAR_SEQ 829
FT /note="K -> KVAYEELLDNRKLE (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045703"
FT VAR_SEQ 830
FT /note="V -> VAYEELLDNRKLEV (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_033596"
FT VARIANT 74
FT /note="R -> P (in dbSNP:rs11649499)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_065205"
FT CONFLICT 228
FT /note="E -> G (in Ref. 3; BAH11566)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="D -> G (in Ref. 3; BAH11566)"
FT /evidence="ECO:0000305"
FT CONFLICT 494
FT /note="G -> R (in Ref. 3; BAH11566)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 910 AA; 97560 MW; 26CC6E04170A5AE4 CRC64;
MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL
RRGPEMGYLP GSDRDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP
ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG
EGYVESPDLG SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL
APRLLANSSM LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD
VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR
IVSPEPGGAV GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS
DMDDVPERGL ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE
YRPGALATFS CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS
PDWPQSYSPG QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ
PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG
DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD
AGFPVGSHVQ YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG
YQTLYKHHYQ AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL
EGGNLALAIL LPLGLVIVLG SGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA
GDTREYEVSI
