SEA2_CAEEL
ID SEA2_CAEEL Reviewed; 1968 AA.
AC A0A0K3AUE4; A0A0K3AQV3; A0A0K3AR28; A0A0K3AR30; A0A0K3ARE6; A0A0K3ARN1;
AC A0A0K3ARN6; A0A0K3AU01; A0A0K3AU05; A0A0K3AUM9; A0A0K3AUN5; A0A0K3AWR2;
AC A0A0K3AWZ4; A0A0K3AX01; S6EZL2; S6F519; S6FCX8; S6FMY4; S6FWN6;
DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Signal element on autosome protein 2 {ECO:0000312|WormBase:K10G6.3g};
GN Name=sea-2 {ECO:0000312|WormBase:K10G6.3g};
GN ORFNames=K10G6.3 {ECO:0000312|WormBase:K10G6.3g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, DOMAIN, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP 415-CYS--CYS-435; ALA-1398; 415-CYS--CYS-418; 1670-CYS--CYS-1690 AND
RP 1670-CYS--CYS-1673.
RX PubMed=21471153; DOI=10.1242/dev.057109;
RA Huang X., Zhang H., Zhang H.;
RT "The zinc-finger protein SEA-2 regulates larval developmental timing and
RT adult lifespan in C. elegans.";
RL Development 138:2059-2068(2011).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=23666922; DOI=10.1101/gad.217026.113;
RA Farboud B., Nix P., Jow M.M., Gladden J.M., Meyer B.J.;
RT "Molecular antagonism between X-chromosome and autosome signals determines
RT nematode sex.";
RL Genes Dev. 27:1159-1178(2013).
CC -!- FUNCTION: RNA-binding protein, which regulates the expression of
CC proteins required to control developmental timing of events during the
CC L2 to L3 larval stage switch (PubMed:21471153). Binds to the 3'UTR of
CC the transcript of the heterochronic protein lin-28 to post-
CC transcriptionally negatively regulate its expression in certain tissue
CC types in the later larval stages (PubMed:21471153). During larval
CC development, controls the timing of seam cell division and terminal
CC differentiation into adult alae (PubMed:21471153). In vitro, it can
CC also bind to DNA through its first zinc finger (PubMed:21471153). May
CC bind directly or indirectly to the promoter of the sex-determining
CC factor xol-1 to activate its transcription (PubMed:23666922). Its
CC activation of xol-1 transcription controls sex determination and X
CC chromosome dosage compensation to promote male development
CC (PubMed:23666922). Through the negative regulation of lin-28
CC transcript, it also has a role in the fox-1-sex-1-mediated
CC determination of sexual fate (PubMed:21471153). Acts in the intestine
CC to play a role in regulating adult lifespan (PubMed:21471153).
CC {ECO:0000269|PubMed:21471153, ECO:0000269|PubMed:23666922}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21471153,
CC ECO:0000269|PubMed:23666922}. Cytoplasm {ECO:0000269|PubMed:21471153}.
CC Note=In embryos, diffusely accumulates in the nucleus at the 20- to 30-
CC cell stage, but nuclear localization decreases after the 200-cell stage
CC (PubMed:23666922). Diffusely localized in the nucleus and cytoplasm
CC during the L3 larval stage (PubMed:21471153).
CC {ECO:0000269|PubMed:21471153, ECO:0000269|PubMed:23666922}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=19;
CC Name=g {ECO:0000312|WormBase:K10G6.3g};
CC IsoId=A0A0K3AUE4-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:K10G6.3a};
CC IsoId=A0A0K3AUE4-2; Sequence=VSP_060636;
CC Name=b {ECO:0000312|WormBase:K10G6.3b};
CC IsoId=A0A0K3AUE4-3; Sequence=VSP_060636, VSP_060637, VSP_060639;
CC Name=c {ECO:0000312|WormBase:K10G6.3c};
CC IsoId=A0A0K3AUE4-4; Sequence=VSP_060636, VSP_060638, VSP_060640;
CC Name=d {ECO:0000312|WormBase:K10G6.3d};
CC IsoId=A0A0K3AUE4-5; Sequence=VSP_060634, VSP_060638, VSP_060640;
CC Name=e {ECO:0000312|WormBase:K10G6.3e};
CC IsoId=A0A0K3AUE4-6; Sequence=VSP_060633, VSP_060638, VSP_060640;
CC Name=f {ECO:0000312|WormBase:K10G6.3f};
CC IsoId=A0A0K3AUE4-7; Sequence=VSP_060638, VSP_060640;
CC Name=h {ECO:0000312|WormBase:K10G6.3h};
CC IsoId=A0A0K3AUE4-8; Sequence=VSP_060637, VSP_060638, VSP_060640;
CC Name=i {ECO:0000312|WormBase:K10G6.3i};
CC IsoId=A0A0K3AUE4-9; Sequence=VSP_060637;
CC Name=j {ECO:0000312|WormBase:K10G6.3j};
CC IsoId=A0A0K3AUE4-10; Sequence=VSP_060636, VSP_060637, VSP_060638,
CC VSP_060640;
CC Name=k {ECO:0000312|WormBase:K10G6.3k};
CC IsoId=A0A0K3AUE4-11; Sequence=VSP_060635, VSP_060638, VSP_060640;
CC Name=l {ECO:0000312|WormBase:K10G6.3l};
CC IsoId=A0A0K3AUE4-12; Sequence=VSP_060635, VSP_060637, VSP_060638,
CC VSP_060640;
CC Name=m {ECO:0000312|WormBase:K10G6.3m};
CC IsoId=A0A0K3AUE4-13; Sequence=VSP_060634, VSP_060637, VSP_060638,
CC VSP_060640;
CC Name=n {ECO:0000312|WormBase:K10G6.3n};
CC IsoId=A0A0K3AUE4-14; Sequence=VSP_060635;
CC Name=o {ECO:0000312|WormBase:K10G6.3o};
CC IsoId=A0A0K3AUE4-15; Sequence=VSP_060635, VSP_060637;
CC Name=p {ECO:0000312|WormBase:K10G6.3p};
CC IsoId=A0A0K3AUE4-16; Sequence=VSP_060632;
CC Name=q {ECO:0000312|WormBase:K10G6.3q};
CC IsoId=A0A0K3AUE4-17; Sequence=VSP_060634, VSP_060637;
CC Name=r {ECO:0000312|WormBase:K10G6.3r};
CC IsoId=A0A0K3AUE4-18; Sequence=VSP_060634;
CC Name=s {ECO:0000312|WormBase:K10G6.3s};
CC IsoId=A0A0K3AUE4-19; Sequence=VSP_060633;
CC -!- TISSUE SPECIFICITY: Expressed in seam cells, intestine cells,
CC pharyngeal muscles and nerve ring neurons.
CC {ECO:0000269|PubMed:21471153}.
CC -!- DEVELOPMENTAL STAGE: In embryos, expressed in 20- to 30-cell stage and
CC expression decreases after the 200-cell stage (PubMed:23666922).
CC Expressed in seam cells, intestine cells, pharyngeal muscles and nerve
CC ring neurons in L3 stage larvae and expression persists into adults
CC (PubMed:21471153). {ECO:0000269|PubMed:21471153,
CC ECO:0000269|PubMed:23666922}.
CC -!- DOMAIN: The Zinc finger domains 1 and 5 bind single-stranded and
CC double-stranded RNAs (PubMed:21471153). The Zinc finger domain 1 binds
CC DNA in vitro (PubMed:21471153). {ECO:0000269|PubMed:21471153}.
CC -!- DISRUPTION PHENOTYPE: RNAi mediated knockdown at early larval stages
CC and in young adults results in an extended lifespan (PubMed:21471153).
CC RNAi-mediated knockdown results in delayed developmental defects with
CC an increased number of seam cells in young adults (PubMed:21471153).
CC RNAi-mediated knockdown suppresses the embryonic lethality of
CC hermaphrodites in the double fox-1 y303 and sex-1 y263 mutant
CC background (PubMed:23666922). {ECO:0000269|PubMed:21471153,
CC ECO:0000269|PubMed:23666922}.
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DR EMBL; BX284602; CDG24088.1; -; Genomic_DNA.
DR EMBL; BX284602; CDG24089.1; -; Genomic_DNA.
DR EMBL; BX284602; CDG24090.1; -; Genomic_DNA.
DR EMBL; BX284602; CDG24091.1; -; Genomic_DNA.
DR EMBL; BX284602; CDG24092.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86419.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86420.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86421.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86422.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86503.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86504.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86505.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86506.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86507.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86508.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86509.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86510.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86511.1; -; Genomic_DNA.
DR EMBL; BX284602; CTQ86512.1; -; Genomic_DNA.
DR RefSeq; NP_001293473.1; NM_001306544.1. [A0A0K3AUE4-2]
DR RefSeq; NP_001293474.1; NM_001306545.1. [A0A0K3AUE4-3]
DR RefSeq; NP_001293475.1; NM_001306546.1. [A0A0K3AUE4-4]
DR RefSeq; NP_001293476.1; NM_001306547.1.
DR RefSeq; NP_001293477.1; NM_001306548.1.
DR RefSeq; NP_001300480.1; NM_001313551.1.
DR RefSeq; NP_001300481.1; NM_001313552.1.
DR RefSeq; NP_001300482.1; NM_001313553.1.
DR RefSeq; NP_001300483.1; NM_001313554.1.
DR RefSeq; NP_001300564.1; NM_001313635.1.
DR RefSeq; NP_001300565.1; NM_001313636.1.
DR RefSeq; NP_001300566.1; NM_001313637.1.
DR RefSeq; NP_001300567.1; NM_001313638.1.
DR RefSeq; NP_001300568.1; NM_001313639.1. [A0A0K3AUE4-14]
DR RefSeq; NP_001300569.1; NM_001313640.1. [A0A0K3AUE4-15]
DR RefSeq; NP_001300570.1; NM_001313641.1. [A0A0K3AUE4-16]
DR RefSeq; NP_001300571.1; NM_001313642.1. [A0A0K3AUE4-17]
DR RefSeq; NP_001300572.1; NM_001313643.1. [A0A0K3AUE4-18]
DR RefSeq; NP_001300573.1; NM_001313644.1. [A0A0K3AUE4-19]
DR AlphaFoldDB; A0A0K3AUE4; -.
DR STRING; 6239.K10G6.3a; -.
DR EnsemblMetazoa; K10G6.3a.1; K10G6.3a.1; WBGene00004751. [A0A0K3AUE4-2]
DR EnsemblMetazoa; K10G6.3b.1; K10G6.3b.1; WBGene00004751. [A0A0K3AUE4-3]
DR EnsemblMetazoa; K10G6.3c.1; K10G6.3c.1; WBGene00004751. [A0A0K3AUE4-4]
DR EnsemblMetazoa; K10G6.3d.1; K10G6.3d.1; WBGene00004751. [A0A0K3AUE4-5]
DR EnsemblMetazoa; K10G6.3e.1; K10G6.3e.1; WBGene00004751. [A0A0K3AUE4-6]
DR EnsemblMetazoa; K10G6.3f.1; K10G6.3f.1; WBGene00004751. [A0A0K3AUE4-7]
DR EnsemblMetazoa; K10G6.3g.1; K10G6.3g.1; WBGene00004751. [A0A0K3AUE4-1]
DR EnsemblMetazoa; K10G6.3h.1; K10G6.3h.1; WBGene00004751. [A0A0K3AUE4-8]
DR EnsemblMetazoa; K10G6.3i.1; K10G6.3i.1; WBGene00004751. [A0A0K3AUE4-9]
DR EnsemblMetazoa; K10G6.3j.1; K10G6.3j.1; WBGene00004751. [A0A0K3AUE4-10]
DR EnsemblMetazoa; K10G6.3k.1; K10G6.3k.1; WBGene00004751. [A0A0K3AUE4-11]
DR EnsemblMetazoa; K10G6.3l.1; K10G6.3l.1; WBGene00004751. [A0A0K3AUE4-12]
DR EnsemblMetazoa; K10G6.3m.1; K10G6.3m.1; WBGene00004751. [A0A0K3AUE4-13]
DR EnsemblMetazoa; K10G6.3n.1; K10G6.3n.1; WBGene00004751. [A0A0K3AUE4-14]
DR EnsemblMetazoa; K10G6.3o.1; K10G6.3o.1; WBGene00004751. [A0A0K3AUE4-15]
DR EnsemblMetazoa; K10G6.3p.1; K10G6.3p.1; WBGene00004751. [A0A0K3AUE4-16]
DR EnsemblMetazoa; K10G6.3q.1; K10G6.3q.1; WBGene00004751. [A0A0K3AUE4-17]
DR EnsemblMetazoa; K10G6.3r.1; K10G6.3r.1; WBGene00004751. [A0A0K3AUE4-18]
DR EnsemblMetazoa; K10G6.3s.1; K10G6.3s.1; WBGene00004751. [A0A0K3AUE4-19]
DR GeneID; 173738; -.
DR CTD; 173738; -.
DR WormBase; K10G6.3a; CE48445; WBGene00004751; sea-2. [A0A0K3AUE4-2]
DR WormBase; K10G6.3b; CE48490; WBGene00004751; sea-2. [A0A0K3AUE4-3]
DR WormBase; K10G6.3c; CE48485; WBGene00004751; sea-2. [A0A0K3AUE4-4]
DR WormBase; K10G6.3d; CE48423; WBGene00004751; sea-2. [A0A0K3AUE4-5]
DR WormBase; K10G6.3e; CE48457; WBGene00004751; sea-2. [A0A0K3AUE4-6]
DR WormBase; K10G6.3f; CE50430; WBGene00004751; sea-2. [A0A0K3AUE4-7]
DR WormBase; K10G6.3g; CE50510; WBGene00004751; sea-2. [A0A0K3AUE4-1]
DR WormBase; K10G6.3h; CE50366; WBGene00004751; sea-2. [A0A0K3AUE4-8]
DR WormBase; K10G6.3i; CE50351; WBGene00004751; sea-2. [A0A0K3AUE4-9]
DR WormBase; K10G6.3j; CE50480; WBGene00004751; sea-2. [A0A0K3AUE4-10]
DR WormBase; K10G6.3k; CE50440; WBGene00004751; sea-2. [A0A0K3AUE4-11]
DR WormBase; K10G6.3l; CE50418; WBGene00004751; sea-2. [A0A0K3AUE4-12]
DR WormBase; K10G6.3m; CE50371; WBGene00004751; sea-2. [A0A0K3AUE4-13]
DR WormBase; K10G6.3n; CE50513; WBGene00004751; sea-2. [A0A0K3AUE4-14]
DR WormBase; K10G6.3o; CE50457; WBGene00004751; sea-2. [A0A0K3AUE4-15]
DR WormBase; K10G6.3p; CE50344; WBGene00004751; sea-2. [A0A0K3AUE4-16]
DR WormBase; K10G6.3q; CE50395; WBGene00004751; sea-2. [A0A0K3AUE4-17]
DR WormBase; K10G6.3r; CE50350; WBGene00004751; sea-2. [A0A0K3AUE4-18]
DR WormBase; K10G6.3s; CE50483; WBGene00004751; sea-2. [A0A0K3AUE4-19]
DR eggNOG; ENOG502SG5U; Eukaryota.
DR HOGENOM; CLU_240032_0_0_1; -.
DR OMA; TINEVIM; -.
DR OrthoDB; 1528947at2759; -.
DR PRO; PR:A0A0K3AUE4; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004751; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; A0A0K3AUE4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IDA:WormBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003727; F:single-stranded RNA binding; IDA:WormBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0007549; P:dosage compensation; IGI:WormBase.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:WormBase.
DR GO; GO:0040034; P:regulation of development, heterochronic; IMP:WormBase.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0009408; P:response to heat; IMP:WormBase.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR PROSITE; PS00142; ZINC_PROTEASE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding;
KW Sexual differentiation; Transcription; Transcription regulation;
KW Translation regulation; Zinc; Zinc-finger.
FT CHAIN 1..1968
FT /note="Signal element on autosome protein 2"
FT /id="PRO_0000450520"
FT ZN_FING 413..440
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042,
FT ECO:0000269|PubMed:21471153"
FT ZN_FING 651..672
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042,
FT ECO:0000269|PubMed:21471153"
FT ZN_FING 856..875
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042,
FT ECO:0000269|PubMed:21471153"
FT ZN_FING 1274..1297
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042,
FT ECO:0000269|PubMed:21471153"
FT ZN_FING 1668..1694
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042,
FT ECO:0000269|PubMed:21471153"
FT ZN_FING 1826..1858
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 72..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1769..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1410..1445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1796..1822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1852
FT /note="Missing (in isoform p)"
FT /evidence="ECO:0000305"
FT /id="VSP_060632"
FT VAR_SEQ 1..867
FT /note="Missing (in isoform e and isoform s)"
FT /evidence="ECO:0000305"
FT /id="VSP_060633"
FT VAR_SEQ 1..338
FT /note="Missing (in isoform d, isoform m, isoform q and
FT isoform r)"
FT /evidence="ECO:0000305"
FT /id="VSP_060634"
FT VAR_SEQ 1..176
FT /note="Missing (in isoform k, isoform l, isoform n and
FT isoform o)"
FT /evidence="ECO:0000305"
FT /id="VSP_060635"
FT VAR_SEQ 1..96
FT /note="Missing (in isoform a, isoform b, isoform c and
FT isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_060636"
FT VAR_SEQ 687..831
FT /note="Missing (in isoform b, isoform h, isoform i, isoform
FT j, isoform l, isoform m, isoform o and isoform q)"
FT /evidence="ECO:0000305"
FT /id="VSP_060637"
FT VAR_SEQ 1816..1825
FT /note="GAKPSTNQAR -> VSGMRQELLQ (in isoform c, isoform d,
FT isoform e, isoform f, isoform h, isoform j, isoform k,
FT isoform l and isoform m)"
FT /evidence="ECO:0000305"
FT /id="VSP_060638"
FT VAR_SEQ 1823..1828
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_060639"
FT VAR_SEQ 1826..1968
FT /note="Missing (in isoform c, isoform d, isoform e, isoform
FT f, isoform h, isoform j, isoform k, isoform l and isoform
FT m)"
FT /evidence="ECO:0000305"
FT /id="VSP_060640"
FT MUTAGEN 415..435
FT /note="Missing: Does not affect expression pattern. Does
FT not rescue the seam developmental timing defects of the
FT sea-2 b283 mutant."
FT /evidence="ECO:0000269|PubMed:21471153"
FT MUTAGEN 415..418
FT /note="CPNC->SPNS: Abolishes RNA-binding."
FT /evidence="ECO:0000269|PubMed:21471153"
FT MUTAGEN 1398
FT /note="A->D: In bp283; extended lifespan, and a slow
FT accumulation of dcap-1-positive P-bodies compared to wild-
FT type, indicative of a slower ageing rate. Delays the L2 to
FT L3 larval stage switch. Defective seam cell development due
FT to delayed divisions and failed fusions during the L2 and
FT L3 larval stages. This increases the number of seam cells
FT at later larval stages and delays their terminal
FT differentiation, resulting in discontinuous alae formation.
FT Ectopic expression of the heterochronic protein lin-28
FT whereby, in contrast to wild-type, lin-28 is expressed in
FT the head, tail and in seam cells of L3 and L4 larvae.
FT Prominent nuclear localization of the transcription factor
FT daf-16 in the intestine resulting in the transcription of
FT daf-16 targets. The seam cell development defects are
FT enhanced in a daf-2 e1370 mutant background. The seam cell
FT development defects are suppressed in a lin-28 n719 mutant
FT background. Partially suppresses the premature alae
FT formation defect in a hbl-1 RNAi mutant background.
FT Suppresses the embryonic lethality of hermaphrodites in the
FT double fox-1 and sex-1 RNAi mutant background."
FT /evidence="ECO:0000269|PubMed:21471153"
FT MUTAGEN 1670..1690
FT /note="Missing: Does not affect expression pattern. Does
FT not rescue the seam cell developmental timing defects of
FT the sea-2 bp283 mutant."
FT /evidence="ECO:0000269|PubMed:21471153"
FT MUTAGEN 1670..1673
FT /note="CSGC->SSGS: Abolishes RNA-binding."
FT /evidence="ECO:0000269|PubMed:21471153"
SQ SEQUENCE 1968 AA; 215234 MW; CCF783E5A020EED5 CRC64;
MGREYKFTGI AAKLNPLNCR LKLEIAEDLD ERVPTTSTSC SVASVAAATA TINTTAPTVL
TKSELQKTLQ KTSSSFSSSL ATTTTTSSHL NAPVESMEGH SSLASYSHHH PSSSHHHHPG
QQQSSSSSSS SHLQDFQSPP SASHPYYHQQ QPQHQHQQAQ QYGQATGSTN GGGQQQMTSM
YGGNDYDQHQ LHHQNQQHQA STSTQQFHHP QRPPPPQYDQ PSSSTGSSLP PLHTVRYEQL
PPPPSNQRTP TQQLQYPVKV VEAGGQAYAQ QVQQAQQSNR SGAAGVNSAL QPKPLPPLSS
ITSISSSAAG SSISAPSTSQ PSTTSSLITS PPSTSSSSMA PRKTPPNASS SSLIKRQSQD
VQEQQRVDFE VARNVSQIMS KNGLKVMHEP LLTGSLPQLA PLAPLPPPKS GVYQCPNCNR
NLANARNLQR HRQTCGSAQH AAPQLAAMLQ RSPPPCASAP PVAPPTAPST SFQHHNSTGN
LTLSYSSSSS RHQSSLYSPQ LEHQDLVGNP NVMLSDGYEY KDDPMLYQGP SGLSDSIWSR
DDSFHSEPPS ASHDQLDMDH LGFPDPLQDP LHHLDSFDSA DHRKETPREC HEPDELMTLD
PTPPQCGSER FYGINIDDMP LSLDCDEPLM RSESASLSSS SQGRNTPAAV FTCEACKKSV
SSERSLRRHY NTCKMFQTEL AASGEERPPT TKRKPATKRP SKKKEASEGP EKNSAILAAL
RKEPAAPQQP QQLQFQQNYQ PSPQFQAPYG GGSLPSISAS WLHSASTSAA AAAPERSEMF
TSPIVTSAPN PYIHQLPHQQ PQQQKSSPLE DLLNEQDESA DDDGDSRSSS GTVSNSTTTT
TTATTTSSKS TGNPLFTCEH CARQLCSMSN LKRHRATCKV AASSSSNSAA SRPPSQPSTP
ATAPATPMLQ ASQAPQPLQA PPQSPMETTA TVTYTKTTVP PSVANTWNTE KAQLISPKPR
SQTIFSEASS SMTVGDALRA QQHQQKMDQQ IQIQFQQQQQ QRFQHHQQQQ QAGRIPPRPP
NPILNQVQNP PQQVQHNQHQ NQMLNPIRQP LLQSPPPPPP KKGLIEHKNT DLVLITSEPL
AERMDAKRRS SEGLVAVTST PLPPIQLPQR SQAPAPSRQQ QQQPPVAYQV QFNGRPLPPM
QLPPLQNPHN QQQQHQMLHQ SQMNYQQVQQ VQQVQHVQQQ QNLQNQHHHQ QQHHQQNQQQ
APGNRSRSHS NVGKMEQEAQ RQGSPLDSII TSVPLSIEVH HHIMKPGPLE QGQSSVDSQS
TAEPSPRKAS QQAYICPECK KTYASRKNVK RHRMAVHKLT LDEILANPEQ PALDPLSAVG
GAGRRHTVAG LETPDSALKP APTKRKASEA PSAGVATKKG KAMAASVDEI QVKEEEEDQK
EETVGSVERQ EPPKKPVADD HKSAIAPLPP ANTIMPPPPP YNQASAVPLN PPRTALPPLQ
LPPLQPLQSE SPSWASMSAP PTALIPRTPR SSEFADEEDT RAMAKIAAEL KRSAEDWPVL
AVIEGVAAEP TNGEDIDEDE ILIKRLRQGG VLEDVGDVSD LLRDVQGGVD GEPFSEDMLL
EKNLSTASSV GLPSLASPGE QFGYQQYSQH PQQHPQQHPQ QHPQQQQQVW NPNYEFQGYM
QQQHPPMPVS QQFQQPLLQR PASQPPPARP IVKNSRRPST TPKPPPNLTC SGCKKILGSD
YSLRRHRAGC ADVQQALNPE YPRPPKRKAA REAQKINEAE ILASMPDPQM VAERSAAVAE
AAAAEAAVER IGALPPPSVV HEIVHQVNAD RQSMKKHNKT TSPPPAQEAP PTCAPDDPMS
SSSSSSTSSA SPLQGGAKPS TNQARHYCQF PECGKNFSSE WNLARHTRES CKMTTRAHSY
EPTSAADKID LIFMDKSKRR VSRTFLCTVS SLISYWLGEQ GDRLELDTKW EHFQLLLDVH
TLKVAITADN INLIAEQSKK YQLEHVIRMA DQFMMNTNYT TPPTHVQL
