SEB2_CAEEL
ID SEB2_CAEEL Reviewed; 480 AA.
AC P30650; P30649;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 4.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=G-protein coupled receptor seb-2 {ECO:0000305};
GN Name=seb-2 {ECO:0000312|WormBase:ZK643.3a};
GN ORFNames=ZK643.3 {ECO:0000312|WormBase:ZK643.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9388664; DOI=10.1042/bst025440s;
RA Coates D., Briggs D.A., MacGregor D., Lynch A.S., Kolakowski L.F. Jr.,
RA Hope I.A., Isaac R.E.;
RT "Characterisation of ZK643-3: a putative 7TM neuropeptide receptor.";
RL Biochem. Soc. Trans. 25:440S-440S(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1538779; DOI=10.1038/356037a0;
RA Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA Waterston R.;
RT "The C. elegans genome sequencing project: a beginning.";
RL Nature 356:37-41(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-95, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: Not known. Putative receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Present in the head body-wall muscles from the L1
CC larval stage through to adulthood. Also expressed between L4 and the
CC adult molt in vulval vm1 muscle cells. These cells play a role in
CC opening the vulva during egg laying. {ECO:0000269|PubMed:9388664}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z11126; CAA77471.2; -; Genomic_DNA.
DR PIR; C88543; C88543.
DR PIR; S23241; S23241.
DR PIR; S23242; S23242.
DR RefSeq; NP_498978.2; NM_066577.5.
DR AlphaFoldDB; P30650; -.
DR SMR; P30650; -.
DR STRING; 6239.ZK643.3b; -.
DR iPTMnet; P30650; -.
DR PaxDb; P30650; -.
DR EnsemblMetazoa; ZK643.3a.1; ZK643.3a.1; WBGene00014035.
DR GeneID; 191374; -.
DR UCSC; ZK643.3b; c. elegans.
DR CTD; 191374; -.
DR WormBase; ZK643.3a; CE33750; WBGene00014035; seb-2.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00940000167994; -.
DR InParanoid; P30650; -.
DR PRO; PR:P30650; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00014035; Expressed in adult organism and 2 other tissues.
DR ExpressionAtlas; P30650; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..480
FT /note="G-protein coupled receptor seb-2"
FT /id="PRO_0000070333"
FT TOPO_DOM 1..222
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..480
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
SQ SEQUENCE 480 AA; 54808 MW; 30284CFE540620AA CRC64;
MNPSISTAGA VVDDFQMSCR FSNFGDHAPE SFDSLSCGAC FYFIFMLVEH YKDRYVASLC
EDTFGVLVCP VDVSDKICNC YNREYVYNIP EFALNSSRIK PLNHLRLDPP LPFQFDLIVK
DCCSAARYCC RNTLVKYHHR VDDSPCPPTW DGWNCFDSAT PGVVFKQCPN YIYGGSNIKT
DYDRLSQKVC RSNGWATPEV NAAAREHTDY TGCMSNGDVE ARILAGLLTY SASVIFLIPA
VFLLTLLRPI RCQPMFILHR HLLISCLLYG AFYLITVSLF VVNDAPLSSQ VFQNHLFCRL
LFSIQLRYLR LTNFTWMLAE AVYLWRLLHT AQHSEGETLR SYKVICWGVP GVITVVYIFV
RSLNDDVGMC WIENSTVAWI EWMIITPSLL AMGVNLLLLG LIVYILVKKL RCDPHLERIQ
YRKAVRGALM LIPVFGVQQL LTIYRFRNVC LIYRLLHKSF CRRMCSEILV ITSGEAGSRS
