SEBOX_DANRE
ID SEBOX_DANRE Reviewed; 293 AA.
AC Q8JJ26; A2BIQ1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Homeobox protein SEBOX;
DE AltName: Full=Homeobox OG-9;
DE AltName: Full=Homeobox transcription factor mezzo;
DE AltName: Full=Skin-, embryo-, brain- and oocyte-specific homeobox;
GN Name=sebox; Synonyms=og9x; ORFNames=si:ch211-110p13.7;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RX PubMed=12397099; DOI=10.1242/dev.129.21.4901;
RA Poulain M., Lepage T.;
RT "Mezzo, a paired-like homeobox protein is an immediate target of Nodal
RT signalling and regulates endoderm specification in zebrafish.";
RL Development 129:4901-4914(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Probable transcription factor involved in the control of
CC specification of mesoderm and endoderm. Acts in parallel with bonnie
CC and clyde, faust and casanova in the Nodal signaling pathway.
CC {ECO:0000269|PubMed:12397099}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Restricted to the mesendoderm precursors during
CC gastrulation. {ECO:0000269|PubMed:12397099}.
CC -!- DEVELOPMENTAL STAGE: First detected at sphere stage (4 hours) in a
CC small group of cells at the margin of the blastoderm. As epiboly
CC starts, it extends over the whole circumference of the margin of the
CC blastoderm, while it is not detected in the yolk syncytial layer.
CC Expression domain extends over 6 rows of cells, that is over a region
CC that includes the precursors of mesoderm and endoderm. At the shield
CC stage, it is also expressed in the invaginating axial mesendoderm.
CC After the shield stage, the abundance of transcripts declines abruptly
CC and only a weak expression is detected in embryos at 60% epiboly and no
CC expression at 70% epiboly or later. Not detected in 4 day old embryos
CC or in adult fish. {ECO:0000269|PubMed:12397099}.
CC -!- INDUCTION: Regulated by the Nodal pathway.
CC {ECO:0000269|PubMed:12397099}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM13128.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF466189; AAM22953.1; -; mRNA.
DR EMBL; BX957226; CAM13128.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001306981.1; NM_001320052.1.
DR AlphaFoldDB; Q8JJ26; -.
DR SMR; Q8JJ26; -.
DR STRING; 7955.ENSDARP00000113809; -.
DR PaxDb; Q8JJ26; -.
DR GeneID; 282666; -.
DR KEGG; dre:282666; -.
DR CTD; 645832; -.
DR ZFIN; ZDB-GENE-021206-4; sebox.
DR eggNOG; KOG0849; Eukaryota.
DR InParanoid; Q8JJ26; -.
DR OrthoDB; 1270742at2759; -.
DR PhylomeDB; Q8JJ26; -.
DR TreeFam; TF315976; -.
DR PRO; PR:Q8JJ26; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007492; P:endoderm development; IDA:ZFIN.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..293
FT /note="Homeobox protein SEBOX"
FT /id="PRO_0000311339"
FT DNA_BIND 58..117
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 117..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 138
FT /note="H -> N (in Ref. 1; AAM22953)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="S -> N (in Ref. 1; AAM22953)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 33386 MW; C751F0865F366E08 CRC64;
MALFYDQSFD LGLVQKINME TESDFIFNTN MLQFTDVTTK HMLSSPELDR TGHVEGQRKR
KRTIFSRAQL SELERAFMIT PYPDITLRER LAALTLLPES KIQVWFQNRR ARSMKSKKLI
TPVSRRSPAK DCTFPATHPD LNLEQSPEAN KSLRHHQQSL IRQALNPWPQ NRPPISPDLP
EILQWANRNS ETPGDSSFSS CPSERIQHPF PNQSSSVWQM NCFAAHPEGL KSYCTTSQAL
YSSVSVDQMI PAHPSSLEEA LQRQALTHYP QTSLGDISDL IYKAAVVTNL EEC
