SEBOX_MOUSE
ID SEBOX_MOUSE Reviewed; 190 AA.
AC P70368;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Homeobox protein SEBOX;
DE AltName: Full=Homeobox OG-9;
DE AltName: Full=Skin-, embryo-, brain- and oocyte-specific homeobox;
GN Name=Sebox; Synonyms=Og9x;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=10922053; DOI=10.1073/pnas.97.16.8904;
RA Cinquanta M., Rovescalli A.C., Kozak C.A., Nirenberg M.;
RT "Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell
RT embryos.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:8904-8909(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 11-190, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=BALB/cJ;
RX PubMed=8855241; DOI=10.1073/pnas.93.20.10691;
RA Rovescalli A.C., Asoh S., Nirenberg M.W.;
RT "Cloning and characterization of four murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:10691-10696(1996).
RN [6]
RP ERRATUM OF PUBMED:8855241.
RA Rovescalli A.C., Asoh S., Nirenberg M.;
RL Proc. Natl. Acad. Sci. U.S.A. 93:15522-15522(1996).
CC -!- FUNCTION: Probable transcription factor involved in the control of
CC specification of mesoderm and endoderm. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, skin, ovary and liver. Also
CC expressed in maturing oocytes, eggs, zygotes and 2-cell embryos, but
CC not 4-cell embryos. {ECO:0000269|PubMed:10922053,
CC ECO:0000269|PubMed:8855241}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos from day 7. Expression is low
CC in 12 day embryos and higher in 18 and 19 day embryos.
CC {ECO:0000269|PubMed:10922053, ECO:0000269|PubMed:8855241}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; U65068; AAC52829.2; -; Genomic_DNA.
DR EMBL; AK143429; BAE25374.1; -; mRNA.
DR EMBL; AL591177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC098184; AAH98184.1; -; mRNA.
DR CCDS; CCDS25107.1; -.
DR RefSeq; NP_032785.1; NM_008759.2.
DR AlphaFoldDB; P70368; -.
DR SMR; P70368; -.
DR STRING; 10090.ENSMUSP00000001130; -.
DR PaxDb; P70368; -.
DR PRIDE; P70368; -.
DR Antibodypedia; 76862; 11 antibodies from 6 providers.
DR DNASU; 18292; -.
DR Ensembl; ENSMUST00000001130; ENSMUSP00000001130; ENSMUSG00000001103.
DR GeneID; 18292; -.
DR KEGG; mmu:18292; -.
DR UCSC; uc007kjm.2; mouse.
DR CTD; 645832; -.
DR MGI; MGI:108012; Sebox.
DR VEuPathDB; HostDB:ENSMUSG00000001103; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00920000149180; -.
DR HOGENOM; CLU_080455_0_0_1; -.
DR InParanoid; P70368; -.
DR OMA; AFAAWPY; -.
DR OrthoDB; 1270742at2759; -.
DR PhylomeDB; P70368; -.
DR TreeFam; TF315976; -.
DR BioGRID-ORCS; 18292; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Sebox; mouse.
DR PRO; PR:P70368; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P70368; protein.
DR Bgee; ENSMUSG00000001103; Expressed in animal zygote and 66 other tissues.
DR ExpressionAtlas; P70368; baseline and differential.
DR Genevisible; P70368; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:MGI.
DR GO; GO:0048477; P:oogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR042223; SEBOX.
DR PANTHER; PTHR47777; PTHR47777; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..190
FT /note="Homeobox protein SEBOX"
FT /id="PRO_0000311337"
FT DNA_BIND 18..77
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 190 AA; 20391 MW; 4D473850504129A3 CRC64;
MASPVEASPG CASGLGPHRR KRTTFSVGQL VELERVFAAR PYPDISTREH LAQVTHLPEA
KIQVWFQNRR AKRIKDRKPG ALNSRLELPP NSCSLPDTPQ LPWDPGTSSH PLHPTSSAQY
TSACPPQTSC LGPILGPGQS WSGAKVAAPW GTSGASGIHS SLEQIVPQTS LGNLSDLIYT
SAIVTNVDHF
