SEC10_SCHPO
ID SEC10_SCHPO Reviewed; 811 AA.
AC O13705;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Exocyst complex component sec10;
GN Name=sec10; ORFNames=SPAC13F5.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=11854409; DOI=10.1091/mbc.01-11-0542;
RA Wang H., Tang X., Liu J., Trautmann S., Balasundaram D., McCollum D.,
RA Balasubramanian M.K.;
RT "The multiprotein exocyst complex is essential for cell separation in
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 13:515-529(2002).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH DIL1.
RX PubMed=20404563; DOI=10.4161/cc.9.9.11526;
RA Rumpf C., Cipak L., Novatchkova M., Li Z., Polakova S., Dudas A.,
RA Kovacikova I., Miadokova E., Ammerer G., Gregan J.;
RT "High-throughput knockout screen in Schizosaccharomyces pombe identifies a
RT novel gene required for efficient homolog disjunction during meiosis I.";
RL Cell Cycle 9:1802-1808(2010).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC -!- SUBUNIT: The exocyst complex is composed of sec3, sec5, sec6, sec8,
CC sec10, sec15, exo70 and exo84. Interacts with dil1.
CC {ECO:0000269|PubMed:20404563}.
CC -!- SIMILARITY: Belongs to the SEC10 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11769.2; -; Genomic_DNA.
DR PIR; T37631; T37631.
DR RefSeq; NP_593654.1; NM_001019086.2.
DR AlphaFoldDB; O13705; -.
DR SMR; O13705; -.
DR BioGRID; 279289; 2.
DR STRING; 4896.SPAC13F5.06c.1; -.
DR MaxQB; O13705; -.
DR PaxDb; O13705; -.
DR EnsemblFungi; SPAC13F5.06c.1; SPAC13F5.06c.1:pep; SPAC13F5.06c.
DR GeneID; 2542843; -.
DR KEGG; spo:SPAC13F5.06c; -.
DR PomBase; SPAC13F5.06c; sec10.
DR VEuPathDB; FungiDB:SPAC13F5.06c; -.
DR eggNOG; KOG3745; Eukaryota.
DR HOGENOM; CLU_008002_1_0_1; -.
DR InParanoid; O13705; -.
DR OMA; HEEETHI; -.
DR PhylomeDB; O13705; -.
DR PRO; PR:O13705; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; IDA:PomBase.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000145; C:exocyst; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR InterPro; IPR033960; EXOC5/Sec10.
DR InterPro; IPR009976; Sec10-like.
DR PANTHER; PTHR12100; PTHR12100; 1.
DR PANTHER; PTHR12100:SF0; PTHR12100:SF0; 1.
DR Pfam; PF07393; Sec10; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..811
FT /note="Exocyst complex component sec10"
FT /id="PRO_0000118949"
FT COILED 106..147
FT /evidence="ECO:0000255"
SQ SEQUENCE 811 AA; 92516 MW; 52E64E1DB702F91E CRC64;
MSTKNALNDS QIKLLNSLND NKGIPSTEFV EKFAESLYET QNDGSKKLSS IDGSIKSFAA
CLHELNRLKS RVGDRIRDYA SASKQVQNEY HQKSNHLREK FAQVLELSRH LEDNVNDMRS
GLVDAGQELE RAENNRKRIL SSAELLRYYL EFRSGKPQTL MDFFRTNNHD KMLLCAQRTR
QLLALANEVD LPDSSETLAR IEKFSEFLET NFLKFFNNEY RKPNWKGMAS FGTILQEFNG
GASVVREFVN QHEFFIAADK VQSRQGLEQD PIWLILPDPT QKIPPLIQTL SSLFSELCSV
IEGDCAVIKR VFPNPELVLQ TFFQRIFGQS IQNRLEEVME IAKGKSNLAY LRTLQTVVSS
LRKLVADLKT ILENRGFSVS DNSPLSLALN QYMEDLLVPF IEVDDYLKRE EHSLRSLFRL
SLYKYTSYKI RLETPEPGLL RSLMTPLQGN MVAPTGVHSQ FNTKTEGFLL RIADIQENLI
QSGSFITEDY ITIEKNHSHL NSEKVYSFIG WHAEALNRAS ILISSQDLSV VISSLVNLLD
KLIREDYVFK ELSSIQSYIS SHDKSKNLDL HYLVDIRECK KIMGYFSAYL MSIVIPFTGV
TASSRRETVN ILSSSISVIE CAVNDVFYAT VHALGDHLEI ILSPYRQISY AMTEEQIDSS
TELRQSMTRN VQNYLDYIKN LYHRLGPYDP SLLALKQKTA TMLAAMLISF AFRSKVTAAG
ALLLQNDINF FHSTLTSWGI DTVDAKFKLI LQLLSLLMVK IDVLPAVMQD KRKAGFSEMN
IHEVLRLRFD LPENLKLQLN KEEALLPPKS S
