SEC13_CHATD
ID SEC13_CHATD Reviewed; 308 AA.
AC G0SA60; G0ZGU9;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-JUN-2015, sequence version 2.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Protein transport protein SEC13 {ECO:0000303|PubMed:21784248};
GN Name=SEC13; ORFNames=CTHT_0041110;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules. It also functions as a component of the
CC nuclear pore complex (NPC). NPC components, collectively referred to as
CC nucleoporins (NUPs), can play the role of both NPC structural
CC components and of docking or interaction partners for transiently
CC associated nuclear transport factors. SEC13 is required for efficient
CC mRNA export from the nucleus to the cytoplasm and for correct nuclear
CC pore biogenesis and distribution (By similarity).
CC {ECO:0000250|UniProtKB:Q04491}.
CC -!- SUBUNIT: The COPII coat is composed of at least 5 proteins: the
CC SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component
CC of the nuclear pore complex (NPC). NPC constitutes the exclusive means
CC of nucleocytoplasmic transport. NPCs allow the passive diffusion of
CC ions and small molecules and the active, nuclear transport receptor-
CC mediated bidirectional transport of macromolecules such as proteins,
CC RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the
CC nuclear envelope. Due to its 8-fold rotational symmetry, all subunits
CC are present with 8 copies or multiples thereof.
CC {ECO:0000250|UniProtKB:Q04491, ECO:0000305|PubMed:21784248}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q04491}.
CC -!- SIMILARITY: Belongs to the WD repeat SEC13 family. {ECO:0000305}.
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DR EMBL; GL988043; EGS19632.1; -; Genomic_DNA.
DR EMBL; JF276293; AEL00687.1; -; Genomic_DNA.
DR RefSeq; XP_006694517.1; XM_006694454.1.
DR AlphaFoldDB; G0SA60; -.
DR SMR; G0SA60; -.
DR DIP; DIP-60575N; -.
DR IntAct; G0SA60; 3.
DR STRING; 759272.G0SA60; -.
DR TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR EnsemblFungi; EGS19632; EGS19632; CTHT_0041110.
DR GeneID; 18258149; -.
DR KEGG; cthr:CTHT_0041110; -.
DR eggNOG; KOG1332; Eukaryota.
DR HOGENOM; CLU_032441_0_1_1; -.
DR OrthoDB; 944756at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0090114; P:COPII-coated vesicle budding; IEA:InterPro.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037596; Sec13.
DR InterPro; IPR037363; Sec13/Seh1_fam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11024; PTHR11024; 1.
DR PANTHER; PTHR11024:SF2; PTHR11024:SF2; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..308
FT /note="Protein transport protein SEC13"
FT /id="PRO_0000433192"
FT REPEAT 15..54
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 59..100
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 105..146
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 151..207
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 215..257
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 263..302
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT CONFLICT 1..4
FT /note="MSQQ -> MVRKTTQTTCPVSVLGCSIVCWAARMSP (in Ref. 1;
FT EGS19632)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 33846 MW; E0B88A61314262A2 CRC64;
MSQQASGAQV ITNSGHDDMI HDAVLDYYGR RLATCSSDRT IKIFEIDGDS QRLTETLKGH
DGAVWCVSWA HPKYGNILAS AGYDGKVFIW RELNGAWSRI YDFALHKASV NVVSWAPHEA
GCLLACASSD GSVSVLEFKD NSTWDYVIFP AHGLGVNSVS WAPATSPGSI VSSKPGPKAT
GNRRFVTGGS DNTLKIWAYD PATNTYKMER EPLTGHTDWV RDVAWSPTVL QKSYIASASQ
DGTVRIWTSD PANPLAWNCK VLHFDSALWR VSWSLSGNVL AVSGSDNKVT LWKENLKGEW
ECVKTIEE
