ID   SEC14_ASHGO             Reviewed;         308 AA.
AC   Q75DK1;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=SEC14 cytosolic factor;
DE   AltName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein;
DE            Short=PI/PC TP;
GN   Name=SEC14; OrderedLocusNames=ABR020W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 4.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
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DR   EMBL; AE016815; AAS50790.2; -; Genomic_DNA.
DR   RefSeq; NP_982966.2; NM_208319.2.
DR   AlphaFoldDB; Q75DK1; -.
DR   SMR; Q75DK1; -.
DR   STRING; 33169.AAS50790; -.
DR   EnsemblFungi; AAS50790; AAS50790; AGOS_ABR020W.
DR   GeneID; 4619058; -.
DR   KEGG; ago:AGOS_ABR020W; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_0_1_1; -.
DR   InParanoid; Q75DK1; -.
DR   OMA; CECAGGC; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0032153; C:cell division site; IEA:EnsemblFungi.
DR   GO; GO:0051286; C:cell tip; IEA:EnsemblFungi.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0005628; C:prospore membrane; IEA:EnsemblFungi.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; IEA:EnsemblFungi.
DR   GO; GO:0031322; P:ascospore-type prospore-specific spindle pole body remodeling; IEA:EnsemblFungi.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:EnsemblFungi.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IEA:EnsemblFungi.
DR   GO; GO:0048194; P:Golgi vesicle budding; IEA:EnsemblFungi.
DR   GO; GO:2001246; P:negative regulation of phosphatidylcholine biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:1901352; P:negative regulation of phosphatidylglycerol biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:EnsemblFungi.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..308
FT                   /note="SEC14 cytosolic factor"
FT                   /id="PRO_0000210738"
FT   DOMAIN          97..270
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
SQ   SEQUENCE   308 AA;  34777 MW;  0B3583EE4796588D CRC64;
     MPTEEELLAS YPSKCAAGSL AGTPGNLTSE HEAALEELRK VLKQAGFTKR LDDSTLLRFL
     RARKFDVAAA RAMFENCEKW RKENGVDTIF EDFHYEEKPL VAKFYPQYYH KTDKDGRPVY
     IEELGAVNLT EMYKITTQER MLKNLIWEYE SFSRYRLPAS SRQADCLVET SCTILDLKGI
     SISAAAQVLS YVREASNIGQ NYYPERMGKF YMINAPFGFS AAFRLFKPFL DPVTVSKIFI
     LGSSYQKELL KQIPAENLPV KFGGQSDVSE AEGGLYLSDI GPWRNPKYIG PEGEAPKAFS
     MSPKPESA