ID   SEC14_CANAL             Reviewed;         301 AA.
AC   P46250; A0A1D8PMX5; Q5A505;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=SEC14 cytosolic factor;
DE   AltName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein;
DE            Short=PI/PC TP;
GN   Name=SEC14; OrderedLocusNames=CAALFM_C500480CA;
GN   ORFNames=CaO19.8556, CaO19.941;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 64385 / 1001;
RX   PubMed=8896277;
RX   DOI=10.1002/(sici)1097-0061(19960915)12:11<1097::aid-yea990>3.0.co;2-e;
RA   Monteoliva L., Sanchez M., Pla J., Gil C., Nombela C.;
RT   "Cloning of Candida albicans SEC14 gene homologue coding for a putative
RT   essential function.";
RL   Yeast 12:1097-1105(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=SGY243;
RX   PubMed=9387231; DOI=10.1099/00221287-143-11-3527;
RA   Riggle P.J., Slobodkin I.V., Brown D.H. Jr., Hanson M.P., Volkert T.L.,
RA   Kumamoto C.A.;
RT   "Two transcripts, differing at their 3' ends, are produced from the Candida
RT   albicans SEC14 gene.";
RL   Microbiology 143:3527-3535(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
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DR   EMBL; X81937; CAA57490.1; -; Genomic_DNA.
DR   EMBL; U61975; AAB41491.1; -; mRNA.
DR   EMBL; CP017627; AOW29492.1; -; Genomic_DNA.
DR   PIR; S57923; S57923.
DR   RefSeq; XP_716780.1; XM_711687.1.
DR   AlphaFoldDB; P46250; -.
DR   SMR; P46250; -.
DR   STRING; 237561.P46250; -.
DR   PRIDE; P46250; -.
DR   GeneID; 3641542; -.
DR   KEGG; cal:CAALFM_C500480CA; -.
DR   CGD; CAL0000199482; SEC14.
DR   VEuPathDB; FungiDB:C5_00480C_A; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_0_1_1; -.
DR   InParanoid; P46250; -.
DR   OMA; CECAGGC; -.
DR   OrthoDB; 1133487at2759; -.
DR   PRO; PR:P46250; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0032153; C:cell division site; IEA:EnsemblFungi.
DR   GO; GO:0051286; C:cell tip; IEA:EnsemblFungi.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:CGD.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0005628; C:prospore membrane; IEA:EnsemblFungi.
DR   GO; GO:0008525; F:phosphatidylcholine transporter activity; IEA:EnsemblFungi.
DR   GO; GO:0008526; F:phosphatidylinositol transfer activity; ISS:CGD.
DR   GO; GO:0031322; P:ascospore-type prospore-specific spindle pole body remodeling; IEA:EnsemblFungi.
DR   GO; GO:0006657; P:CDP-choline pathway; IGI:CGD.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:EnsemblFungi.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IEA:EnsemblFungi.
DR   GO; GO:0048194; P:Golgi vesicle budding; IEA:EnsemblFungi.
DR   GO; GO:2001246; P:negative regulation of phosphatidylcholine biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:1901352; P:negative regulation of phosphatidylglycerol biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IGI:CGD.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..301
FT                   /note="SEC14 cytosolic factor"
FT                   /id="PRO_0000210739"
FT   DOMAIN          99..272
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
SQ   SEQUENCE   301 AA;  34709 MW;  1F194A8EA8B525BE CRC64;
     MTTMTTEEIL ASYPQITAPT DQTGYTSNLT PEQKTTLDIF RQQLTELGYK DRLDDASLLR
     FLRARKFDIQ KAIDMFVACE KWREDFGVNT ILKDFHYEEK PIVAKMYPTY YHKTDKDGRP
     VYFEELGKVD LVKMLKITTQ ERMLKNLVWE YEAMCQYRLP ACSRKAGYLV ETSCTVLDLS
     GISVTSAYNV IGYVREASKI GQDYYPERMG KFYLINAPFG FSTAFKLFKP FLDPVTVSKI
     HILGYSYKKE LLKQIPPQNL PVKFGGMSDV SDDDLLLKDV GPWRDPEFIG PEGECPRAYN
     I