ID   SEC14_YARLI             Reviewed;         492 AA.
AC   P45816; Q6CAA5;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=SEC14 cytosolic factor;
DE   AltName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein;
DE            Short=PI/PC TP;
GN   Name=SEC14; OrderedLocusNames=YALI0D04488g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   PubMed=8138566; DOI=10.1083/jcb.125.1.113;
RA   Lopez M.C., Nicaud J.-M., Skinner H.B., Vergnolle C., Kader J.-C.,
RA   Bankaitis V., Gaillardin C.;
RT   "A phosphatidylinositol/phosphatidylcholine transfer protein is required
RT   for differentiation of the dimorphic yeast Yarrowia lipolytica from the
RT   yeast to the mycelial form.";
RL   J. Cell Biol. 125:113-127(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA35249.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L20972; AAA35249.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CR382130; CAG80595.1; -; Genomic_DNA.
DR   PIR; S43745; S43745.
DR   RefSeq; XP_502407.1; XM_502407.1.
DR   AlphaFoldDB; P45816; -.
DR   SMR; P45816; -.
DR   STRING; 4952.CAG80595; -.
DR   EnsemblFungi; CAG80595; CAG80595; YALI0_D04488g.
DR   GeneID; 2910641; -.
DR   KEGG; yli:YALI0D04488g; -.
DR   VEuPathDB; FungiDB:YALI0_D04488g; -.
DR   HOGENOM; CLU_014001_0_1_1; -.
DR   InParanoid; P45816; -.
DR   OMA; ASRHATH; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..492
FT                   /note="SEC14 cytosolic factor"
FT                   /id="PRO_0000210743"
FT   DOMAIN          98..271
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REGION          274..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  52607 MW;  C64278E9B6A0113C CRC64;
     MTVTEQEFLA SYPQKVAPGG PTGYPGNLTA EQEQKLGELK MILLTKGYED RTDDATLLRF
     LRARKFDVPL AQEMWENCEK WRKEFGTNTI LEDFWYKEKK EVAKLYPQYY HKTDKDGRPV
     YVENVGKVNI HEMYKITTQE RMLRNLVWEY ESFVRHRLPA CSRVVGHLIE TSCTILDLKG
     VSLSSASQVY GFLKDASNIG QNYYPERMGK FYLINAPFGF STVFSVIKRF LDPVTVSKIH
     VYGSNYKEKL LAQVPAYNLP IKFGGQSSSK IGVELSDDGP WRDPQFVGPE GLAPVAGERP
     TGAPSIVSNS STYAKSTAST KVGADDKATD AKANGNGAAA AAAGAGTAAA GGAAAAAGAS
     SSKQAAPAQA APAQAAKAPV PAAAKTATAP APTGKTAAPQ TNSFPPEMLA MMEQNEKKAE
     KAAEAKTKGG AAPQANAFTD EQLAQLNSLP QQVATGGVSQ PLPDSHVTQG VPTVAKIAEA
     AAGPHEDAHL PH