SEC15_SCHPO
ID SEC15_SCHPO Reviewed; 768 AA.
AC O75006;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Exocyst complex component sec15;
GN Name=sec15; ORFNames=SPCC1183.01, SPCC1672.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP IDENTIFICATION.
RX PubMed=11854409; DOI=10.1091/mbc.01-11-0542;
RA Wang H., Tang X., Liu J., Trautmann S., Balasundaram D., McCollum D.,
RA Balasubramanian M.K.;
RT "The multiprotein exocyst complex is essential for cell separation in
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 13:515-529(2002).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC -!- SUBUNIT: The exocyst complex is composed of sec3, sec5, sec6, sec8,
CC sec10, sec15, exo70 and exo84. Interacts with sec4.
CC -!- SIMILARITY: Belongs to the SEC15 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20451.2; -; Genomic_DNA.
DR PIR; T40841; T40841.
DR RefSeq; NP_587884.2; NM_001022876.2.
DR AlphaFoldDB; O75006; -.
DR SMR; O75006; -.
DR STRING; 4896.SPCC1183.01.1; -.
DR SwissPalm; O75006; -.
DR MaxQB; O75006; -.
DR PaxDb; O75006; -.
DR EnsemblFungi; SPCC1183.01.1; SPCC1183.01.1:pep; SPCC1183.01.
DR GeneID; 2538937; -.
DR KEGG; spo:SPCC1183.01; -.
DR PomBase; SPCC1183.01; sec15.
DR VEuPathDB; FungiDB:SPCC1183.01; -.
DR eggNOG; KOG2176; Eukaryota.
DR HOGENOM; CLU_009437_2_0_1; -.
DR InParanoid; O75006; -.
DR OMA; RDHYNEV; -.
DR PRO; PR:O75006; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; NAS:PomBase.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IC:PomBase.
DR Gene3D; 1.10.357.30; -; 1.
DR Gene3D; 1.20.58.670; -; 1.
DR InterPro; IPR007225; EXOC6/Sec15.
DR InterPro; IPR042045; EXOC6/Sec15_C_dom1.
DR InterPro; IPR042044; EXOC6PINT-1/Sec15/Tip20_C_dom2.
DR InterPro; IPR046361; Sec15_C.
DR PANTHER; PTHR12702; PTHR12702; 1.
DR Pfam; PF04091; Sec15; 1.
DR PIRSF; PIRSF025007; Sec15; 1.
PE 3: Inferred from homology;
KW Coiled coil; Exocytosis; Protein transport; Reference proteome; Transport.
FT CHAIN 1..768
FT /note="Exocyst complex component sec15"
FT /id="PRO_0000118958"
FT COILED 69..115
FT /evidence="ECO:0000255"
SQ SEQUENCE 768 AA; 88550 MW; 7639A682EDEB0839 CRC64;
MDIDVLEFVD KIASIESAGD TLDRLPQLIS LACEKGQETQ VYERLNELAS KSAIRVEQLS
AENNQDFSKS VNQLSVVRSE LRSLQSLMAD LNTDIQASGR DLQNMKQQLN SLSTSERFLT
KYHNLVRSCM QVLHQVQYSQ ELLSKKQYLP TLRICSEISE VHLKRLDGLG MYSTIQQYIV
TTKEAICSAV MEDLHEWLFS IRQKLPLVGK SCSQQIDEAR RRWAREYKED LVNLSSKTSI
SLELYLLEMM DFSPLDNEIV KISFEPLYIC LQVHSYLGLL SSFRSSFERD RRRQQEFLAP
KSLTTLDMAV VSEWLNSIAG FMIVEYYILQ CIPNFRSYEE VQNIWTIICE KLVETILSVA
FTEQSTTTII KLKNQIVLLM HTMERFGFSV ESLRNLCVEL IDAFGGALIL KHSVFFEEAF
EKDVYAPMIV ETQEEYDHYI APYWNFPSEP FPRTMSFSKM CPLCCTTLSK FVRHFFMFLN
DSVILATEVN EKAPRFYRRF ILRSLVDRLK SLYPKLALSQ MSQLVKNFYA FEDPLLQIEK
SLVLNKPIHQ IGAEASSSNN VKSTELLEGL ANARKSALHE IFVKINLKID DFLGLAEYDW
TTTQVRKDVS GYLQEMVTYL QTMYLESLAG LPKHDKSYVY LETLDHLCTA MVDLLSDPSI
RKVTTAAAEG FKLDVEYLES FAAQVPDQSI VNADSFIELR QCANLLLGDN MEEYLDTDKF
MRDFNRLQPA VAIKFLERHI NNYSANPLSN DRPKRRAIEI LIATLKKR
