SEC16_ASHGO
ID SEC16_ASHGO Reviewed; 2272 AA.
AC Q74ZJ8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=COPII coat assembly protein SEC16;
DE AltName: Full=Protein transport protein SEC16;
GN Name=SEC16; OrderedLocusNames=AGR202W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC16 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54692.1; -; Genomic_DNA.
DR RefSeq; NP_986868.1; NM_211930.2.
DR AlphaFoldDB; Q74ZJ8; -.
DR SMR; Q74ZJ8; -.
DR STRING; 33169.AAS54692; -.
DR EnsemblFungi; AAS54692; AAS54692; AGOS_AGR202W.
DR GeneID; 4623170; -.
DR KEGG; ago:AGOS_AGR202W; -.
DR eggNOG; KOG1913; Eukaryota.
DR HOGENOM; CLU_000768_0_0_1; -.
DR InParanoid; Q74ZJ8; -.
DR OMA; VPNAGPY; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0070973; P:protein localization to endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024468; Sec16_N.
DR PANTHER; PTHR13402; PTHR13402; 1.
DR Pfam; PF12931; Sec16_C; 1.
DR Pfam; PF12935; Sec16_N; 1.
PE 3: Inferred from homology;
KW Autophagy; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..2272
FT /note="COPII coat assembly protein SEC16"
FT /id="PRO_0000295527"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2043..2125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2146..2187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..595
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..676
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1694..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1750..1812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1990
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2272 AA; 244543 MW; A4124F4427B5B9A9 CRC64;
MSTEAKRRRN QKKKQKQKQK KAAEKMQEQA SLESTLGSPI DVSIFEQQQY GGAEDAEAAG
AAAARESADE SRGASVESSG STDNAIGDDR AGSAPSPYVA VGDSAAVSTA VEVSAPLQDE
AFSAVDVEAT ESPASALPAA SVEESEHVSI ATPAEPSAAP VAPEAAASEE NVVQMAGENG
TNPEADVPIE DESNFLFGDS PHSPLPWDDG GASDPEQRPE MTEERPELPT FEEERTQHTS
LLPSTSNEHK TPQEALSSEE DQAAEPEQNI GVCDGHAEDS TVDVEWEQHT SSSELFGEEH
DTPHSPLPWE EQEAAAPEEN RSRMEEHKES ISGDERDQDV PITEDSAKTG SLPEDTVPGE
NTPGDIPETA TSAKNVDFDS ANGTGNVPVE SQAHSTTHTP EEYAADSNSL FALEDDGGDF
LAELSNGHDV SSQSAADMLP IDDNVPRTTF DGADALAGPA ETYEPGDLFA DEDTAEEPPW
AQNTNPNVDT SQQLPVSRSS AELSSSQAAK ETPGIEVPPP MFWDEESDSI EASNDQLAFT
PVAQRGKVTL PDKKFSFLDN DDDLLNDDEE EEANAGDQPE NDQENCDDDS FLDSDEEPPL
LPPKAGKTTY TPSTQVLGQD RSSYDAHNLS SSMAVSPAVA AVTGQQQFLP GPPVPEKPKV
GKYALPKQPN PPPQTNKGYY APTLGGVGLE ATDKPPVLSV NDESVRRLEE EKKKSDAYDF
PLELVKSKPK PAKPVPVPSI PSIVTASQPA SRSFSPSDAQ PVFSPEKAGI TPLKPTVPPV
KNPYQPNFDG NYLSLVDAVN SRTSSVQQNP YAPPPVNVGP QVTSEKPYAA YEGAASGSQS
QHPFPPQPLG AYGTNAPKPP LNSYNLAAAQ MDSPKERRPA AYVNTSRTRA ISNASVGSSG
SYNSHQLPAG PTVVPPRFAF PPPQAHISPT IPALQTVGIA GAPPAVSSPG TQRRTHARSH
SSVYAPANAP HASKYAPTVH PSVQQKYPSV AGPSKRSLAG NGVPDGVSNR VLPPTIQEVP
VDGHALNFRQ FPLFNWSQTS KIVYGLSLPI DTGNYMLGKP FPVSGIHVRN SESILVPNVI
LKDFPGPLIK GKTRTKDLEK WLELSIAYQR ESLPGRDLTL WYVLKHKLST SGSLRELSKI
LYDSDQLIPY MGQMHSHGRP TLLSHKLDPN SQMQILAHLQ VGSPGAALDL ALAQKDYALA
LVLSSLIGKD KWSEVVDTYL REEFSVSAGN NQFSVYLLAL IFQVFVGNSN RVLQELTANP
LKRDWAIQDW NIILAAVLNN IPKDVDPRQL PPVVMEFLVG FGVFLVQSGK LAAGAVCFVI
ANVPLSQNEL LPHSGVKFEC LGSINSLDAV LLSEVYEYYY TTINDNCPFF ASLLLMKTVH
ASALLDYGLP TTVPKYLDVI TGLLRNAPKN SAIAVSLTHQ LESINLRLSG VTTAWIGKPT
LSSVWGQLDK SFNKFIGGDA DDFSKQPEKT VFDSFTPSAS RNASMVDLNH GVTPMRPSAI
KNSGVNRSHT DLPVSNKGGY APLNAPGSNV FSVSRSNNHP HGTEHGNSMS NLHGDSQHLT
HKTNYTPHRA SNLISPKYPE EPQNSHLPNQ QSNLPSPANG HSRNPSIPSV ATPPPIFSAP
PKRARGKYAA TASGAVSVDQ LYSDAGHSNT PTKVKSVPTC PEIAETPAAL ATRQATDSMT
DFFAPPLLQA GLQQDRRSSA YSASSQGILP SSRRSSNISD VMLPPKKSGS GKPYRKTTVN
YTPIDMEASS LAPSSVSLSQ STGDTTTEVK RARNSGEASN SSATEVADST VLHKSPESVD
TSEYSFPDES VQSWEENAED DQDPLHTVSA ISNTEVPVDK RDGERGSQNT LTKAAPYSDL
APYEHEGNAP STESPAIKGS RVQVQVQVTP PEDFAHIQSQ VVSPEKEASP TVEKGANANE
SSPDLHERQP YAGLGVSYNP NTGGPRPFAS HQYLPRAPAV PAYSPIEENA AEEGRTDNQT
KAVEKQEHAV LKRTVSGPVI GSEKLMSPAL AHPIPRTSRF EPIKEIIQND EDTFRKDKVP
VIRASSNPNF NPYTPVASEQ YYDDVVEDES DDSEEESERK RQEKEKEEER KREAAEKEKR
KNEGGGSSRW FGWLKKDTNE KKPIKAKLGQ KNNFYYDEKL KRWVNKDATE EEKQKVSTPP
PPPPVVKRKM NTTPEIKPRS GSVVGGPAIR TQGAVAPVNP QDPQPCQAVV GASSALQKQA
SPVKPRDPAI NLTSKKANGL DDLISLTAGP SNAVSRRKKK PGRGYVNVLN NL
