SEC16_KLULA
ID SEC16_KLULA Reviewed; 2082 AA.
AC Q6CM10;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=COPII coat assembly protein SEC16;
DE AltName: Full=Protein transport protein SEC16;
GN Name=SEC16; OrderedLocusNames=KLLA0E23958g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC16 family. {ECO:0000305}.
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DR EMBL; CR382125; CAH00116.1; -; Genomic_DNA.
DR RefSeq; XP_455029.1; XM_455029.1.
DR AlphaFoldDB; Q6CM10; -.
DR SMR; Q6CM10; -.
DR STRING; 28985.XP_455029.1; -.
DR EnsemblFungi; CAH00116; CAH00116; KLLA0_E23915g.
DR GeneID; 2894352; -.
DR KEGG; kla:KLLA0_E23915g; -.
DR eggNOG; KOG1913; Eukaryota.
DR HOGENOM; CLU_000768_0_0_1; -.
DR InParanoid; Q6CM10; -.
DR OMA; ESHENGY; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402; PTHR13402; 2.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Autophagy; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..2082
FT /note="COPII coat assembly protein SEC16"
FT /id="PRO_0000295538"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1756..1787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1955..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1413..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1650..1672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1700..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1761..1787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2026..2045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2082 AA; 226997 MW; 510722B60D2A4D14 CRC64;
MGPDAKKRKN QKKKLKLKQK RLHASNGSAD ESAIVPQTTD VHLESSAEAI GSVRSVNAQV
SPQSEASQAD TPQLVHTEAI PDAVPEHNDL SDLFQQENND TIANEAAVFD SIVKEQAPDV
PVVAAAFTND ANVGNVGTLN NAQHVSNEIT ASEKAPDSVI GSMPVEAQPS VINDPVEELF
GNDDTVQTEG LPWQDQIIAE ELPSISAEVG RELPQQESIN DYDQQEQFPP LLHDEKNTVQ
LDQSEREVAT IENFNEPLSQ VNDGRKAPNM VTLDALLDDD NDYLTSDNDT QGMEHEATPT
ELVSGENSSP VQPVNDAIEK ATGDEDTDLF NSEGDDGAKE GLSWLNDQSN TQEIPSPSEE
ATKFSFLEND DDLLDDDESL LDSDEEVIVP QPQTAQAPKK SYLPSASSPV PQSVKHSYHP
QSNPYSPQAS SFSNSVSGQP PSFPQNPSSY TYPVASTVPA SVAPGIVKPK LINNSNSSQS
SVSDVNELHK KLDEAKHRTD AYDFPLDLVK QEIKRGKPMH ITSPLPSIRQ PSFSSVASEK
PLIQPPVRPQ PNNTKAPQKP FYAELPIPEL KPTRAAPIRI ASQNSFSGSS ALPSQPIAAQ
SRRTSIDPPV NPYAPKKNVA VVNPTIAPNS VAYGINNVPS KGQNLQANIL SAPPRNTIVS
PVGTIAHNPY TPSLKSTASS SIKETPYQPA QPRRNRVLTN ASADSAGSFN PGHIPPIPGV
PSTESNIYSF PPQHLSTAAP TATDHLQTTF DSHNVPPVLS PTLSTTANNK KTHARSNSSI
YAPAHHAHSS KYAPTVHPQF QQQQQQQHQQ QHQQQQQLQQ LQLLQQQQQQ QQQQQQLNGI
PVGFPRSQVD SNYGYASQQN TNQPIASTFP IMDQSRNPSI QANGSYIVSR QFPIFHWGKS
AKVVVGIPNT QDYISAVEPK LDSINVISND SILTLDKTLE QFPGPLIKGK SKSKDIAKWL
DTYIEEKKLK GANDTCILLE LLKLRLDPSY SLKAVTNIIY DSSILLPYLS QPFIPKVAAP
NAHKLDANSL IRVLTLLQTG AHDDALNLSL ALKDYAMALL LGSILGKEKW SSVVDQYLTQ
EFEQSNERDI SSINLLATIF QVFIGNSKKV IDSFKQDPTK LEWSLNNWKL LIACILNNCE
EVPANGKLSP IVVEFLLQFG ELLVSRGLVI AGSIAFIVAD IPMSEEPLIP FSSTTFEYIC
CPNSFESLIL SEIYEFTYGQ KDPSFSGFTS LIPQKIIHAA GLSDYGLNSS STKYMDMAQS
MLKSLPKNSE TTLKTLRYIE DLSNQLSSSN VGWLGKPKLS SVWGQLDKSF NKFIGGDTDI
DESETAAIED KVFEKFTPTS SRNPSMADLS QAASYLTPAL NRSHINQLQS NNSSLIKSTT
KILPASSLPS RETHSKYGPP PLRDMKPQSK IGELYGSHSN IEPLNSTASA RNTVHPSHFE
EPDNYVNPSG ATSLGQKELP NSNSTPEPVL PPLAQVYPGY QIHHDLSDGN SSVSSGHRLY
SKMGVPNQNT ASFCVPSPIV SPQSTKHQSS TSNKALPLEN LFDDTVTSGL TTESTQTGSN
APPRFHENEQ HSVVDDIVEE IGNEIDAELD ELQHSEFSDD NNFESTEQNS ISGVEGSVSQ
LNVTNQLPVA ENLQEEDKNQ VTDINVPVTQ AQPLNSFSPA SSISSKPSSL KNMSVDKAEP
ANPYAPKNSF GVAPRTARKS YNPYSPSSIT ESHSMASLPQ TSTSPYNNDN NSAPVNETGG
PEDLAMYAYG SYKLSGEDAK PQTIDSPNGQ KQEIENKTSS PPLNSFVPSN IGLGENLISV
KSIGLPAHLQ NDSQTLPSSK IKDPVIRPVQ TSNFVPFIVS DTNTEEYYDD LVEDTEDEDE
DEPISVKREI SERNSENQNQ KVKNDEDEDE VKTVSEDEAG KPDKKQKNES SGGWLGWFKK
DSNEKKPIKA KLGHANNFYY DENLKRWVNK DATEEEKLKV ATPPPPPPVV KRKMSKTPEI
KPRQGSVVGG PALRTAHAVM PTNPLTGKPL DPVKDFSDDA ETKSESPVSS KPPVSNTNVN
LSGSKANGLD DLMALTGGVS SASSTRRKKK STRGYVNVME NL
