SEC16_PICST
ID SEC16_PICST Reviewed; 2212 AA.
AC A3LZ57;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=COPII coat assembly protein SEC16;
DE AltName: Full=Protein transport protein SEC16;
GN Name=SEC16; ORFNames=PICST_68327;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEC16 family. {ECO:0000305}.
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DR EMBL; CP000501; ABN68097.2; -; Genomic_DNA.
DR RefSeq; XP_001386126.2; XM_001386089.1.
DR AlphaFoldDB; A3LZ57; -.
DR SMR; A3LZ57; -.
DR STRING; 4924.XP_001386126.2; -.
DR EnsemblFungi; ABN68097; ABN68097; PICST_68327.
DR GeneID; 4840445; -.
DR KEGG; pic:PICST_68327; -.
DR eggNOG; KOG1913; Eukaryota.
DR HOGENOM; CLU_231080_0_0_1; -.
DR InParanoid; A3LZ57; -.
DR OMA; VPNAGPY; -.
DR OrthoDB; 555132at2759; -.
DR Proteomes; UP000002258; Chromosome 7.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402; PTHR13402; 2.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Autophagy; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..2212
FT /note="COPII coat assembly protein SEC16"
FT /id="PRO_0000295543"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..1927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1960..2212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..555
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1484..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1912..1926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..1975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1985..2000
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2001..2032
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2063..2078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2111..2141
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2212 AA; 240375 MW; 8D462E56E028DB3E CRC64;
MSIRKSTTSP VSGTDRADLN DSFAVSEAEP SQLHGHVEYG ADVSVGVEDA SGFTAEDAFQ
VGGEEDEEQV STVTNGAVVP QSVVAAESAD EDVLSRSTKK EEFLPESTSI AEPVKSDVIT
NVIDANADTG LDDDPWMKDG TPEFPPADEN LPEVPPVAET KVETSKSIAK QQIYGEKVED
FTENSASPQE VDSKQTSSTI ADFIPTPEHI HSNLHTSETE NEPIKQSQLP WESHVEQIEA
LPWEEQPQKV EHVLPWEEKP DEVSQKDEAL PWEERRVEHP EQAAESTLPW EEQPNVEEFQ
AHEPALPWEE RPEVEESSLP WEEKVGESQG QEAALPWEEQ QEVEVSSLLL EEKVRESSLP
WEGEEGESQA QESKLPWEEQ RIQSTPPSEE QVLEPVEGSS LPVEEKDSTE GSLPWNQHHE
GEAQEILPWE QSTKPQDTQP QVSQEELHDY SVSNVISQSE IVEEQAQPVS QAYESQFLAG
FFTERRPEQE SETKQESLDE LFEKDEDFLP ELKQPVEQST QTSKPKEFNL PELDLDDDLL
LDDDLLDDDE PELVPEPVAP VEPIQEAIQN NVAKSPRQTY IPTQPHHNMY APQISRTDTG
EYVKKLEENK KRNDAYDFPD ILMPPKVKPA PRHHQPTTKY SQPVASPNLS NIPSAPPATT
IPPPVSIGIE ASKKELPTTP QVAPGKPKSF FEELPVSMPK KAARAAPVKA VNQPHIQKSP
QISNTPISAS SKPAPVNPYM PSNTQKQNPH SPLQGSQYSF PRKTSSGLAP PPALNQYAPP
SSNQYATVSA QVQPGLPQSS LPQSGMSQPG LQPFPQPQGH LVPPNLVAPQ IQNSPLGQPQ
QTHNYAPPIN TNVARAQGNL SATSPYVPNA GPYAPNNHNR SHSRASSLVG GGKGKEINPY
APALPPVSHS GTSPSIAQSS LTSRNRGISN PRNIYSKAQP APKISNPNSL NQRQFPIFNW
SNSQKVVTLI PNSSHNLYES HGESIRVRAA IDLLKDKEMY STFPGPLSKS KTKRKDVEKW
LESNIALLTT NSIENQDEYL LNQVLLEAVK FEGGFNSHEF IKAVCMVLNP TADYNTPGDI
SGMTSVSANA YKLDNAGIGI VFGLIQGGHI DKALEFTLSK GDWALALVVS NFAGHDRFAK
VAADYARFSF PYQKSNNKIH HIIPILLKLA VGNVKSVIDD LNAVATEGEY ASHHWREIVS
SVIISGVSKS QDFLVEFGKF LGLHHNIAAS EICYVIAGLP LSPQALQPSG IVVSVIGSLT
GTSMYTEVYE YILKISTVFV QQGVGIIPHL LPLKLKHATV LADYGLFNES QKYIDSINNN
MKTLGNRSPY LNAAFIHELQ SLIVRLQELG SSESSWFSGK MSKVNLDNIW GQIDKFIGGE
EPKSKSGENG VFSKFSPSVS RNTSTLDFTA MNVSSNKYPH SSPQMPSGQF GSSSIAPSTA
DGVSVPVTRA MPPLQSFNST PAINTLSMNS KYSLPHLQQT KNASFSVHSQ STQVPPSHHS
TPQQSHVHPN VPLHHAAESK YSPSNASPQV PDSTASPYVP PVKRTTPRVA AKAVNATGPY
VYANPEGHVS NSSIGSHRQH GYHPPTSQTP TVNAKRHSVA SVISNEATPN SEVIHSHHNH
SPSIQSDISM DYPSEFKPPP AVKQIVDHKL VSALNDHAPD TIDESPEFKS EAIVEKVPPL
SASQEVSGQP SAASTSVPSS EKAATVDDET TSSAASAPPP QSKASLKKPA KVNPYAPGAN
RSGTARKSKY GPPTGASSSK YSVPANLAQQ DEPINDDTLK YGSMFDYSGY KTGEPTVADN
DNVEPPTQSE TTSKHAAEED VTELIVEPKP SIPESPSAPK IVREPETSAP PHFKQPESHF
APFGYNTPLK ARTKHYANID DSFDNSEVSG DQDLTDIHTP RKRPLILNNG PPQLTGKESM
FNPYQGDSGV NKFGLDFPIP GSPDYTTRAN SVVDQPGYFS SRLSQSQQSA LYQQYEVEDD
TVRDYVPTVE EDDEEDEDEE DRDKKRLQEE EEKRAKAASE EAKKKASEAA AKRDPGRGWF
NWSGKNDGKP KPIKAKLGNP STFYYDEKHK RWLDKSRPIE EQLQAAAPPP PPAMKKKAPA
ASSNITASSG PPSAGPPPGI NPSGVAPTAA PSGPPSAPSG VTSGPPSIGT GPSNGAGGPP
FAKATSVQSS APSLANAGLD DLLSMGGSSV AGGTRKAKRN TRRGHINVFD KK
